Cassava is a root storage crop that is important to the starch industry and food security. We studied sustainable fertilization of cassava using local placement of struvite, a fertilizer recovered from wastewater, rich in nitrogen, phosphorus, and magnesium. We asked if struvite is a suitable fertilizer for cassava, if it is likely to spread through the substrate (leach), and if roots can proliferate and utilize a concentrated placement of struvite. Cassava was grown in rhizoboxes under different fertilizer placement strategies: unfertilized control, homogenous fertilizer distribution in the top 20 cm (‘homogenized’), a strip placement (‘layer’) at 20 cm depth, and a localized ‘depot’ at the same depth. Shoot and root growth responses were monitored over 8 weeks. Cassava growth was significantly improved with struvite fertilization. The fertilizer remained localized, with minimal spread during the 8 weeks of experimentation. Both the ‘layer’ and ‘homogenized’ struvite placements resulted in comparable biomass production, significantly greater than the unfertilized treatment. Plants in the ‘depot’ placement initially grew similar to the unfertilized treatment as roots took time to locate and proliferate into the fertilizer depot. Afterwards, plants in the ‘depot’ treatment grew quickly resulting in an intermediate biomass at harvest. Notably, cassava exhibited strong root proliferation in response to concentrated struvite, which did not compromise deep rooting but instead appeared to enhance it, increasing specific root length. These findings suggest that strip fertilization with struvite may offer a sustainable fertilization strategy for cassava, warranting further investigation in field trials.