This article presents a review of the fluid dynamics, flow-structure interactions, and acoustics associated with human phonation and speech. Our voice is produced through the process of phonation in the larynx, and an improved understanding of the underlying physics of this process is essential to advancing the treatment of voice disorders. Insights into the physics of phonation and speech can also contribute to improved vocal training and the development of new speech compression and synthesis schemes. This article introduces the key biomechanical features of the laryngeal physiology, reviews the basic principles of voice production, and summarizes the progress made over the past half-century in understanding the flow physics of phonation and speech. Laryngeal pathologies, which significantly enhance the complexity of phonatory dynamics, are discussed. After a thorough examination of the state of the art in computational modeling and experimental investigations of phonatory biomechanics, we present a synopsis of the pacing issues in this arena and an outlook for research in this fascinating subject.

3D bioprinting has begun to show great promise in advancing the development of functional tissue/organ replacements. However, to realize the true potential of 3D bioprinted tissues for clinical use requires the fabrication of an interconnected and effective vascular network. Solving this challenge is critical, as human tissue relies on an adequate network of blood vessels to transport oxygen, nutrients, other chemicals, biological factors and waste, in and out of the tissue. Here, we have successfully designed and printed a series of novel 3D bone scaffolds with both bone formation supporting structures and highly interconnected 3D microvascular mimicking channels, for efficient and enhanced osteogenic bone regeneration as well as vascular cell growth. Using a chemical functionalization process, we have conjugated our samples with nano hydroxyapatite (nHA), for the creation of novel micro and nano featured devices for vascularized bone growth. We evaluated our scaffolds with mechanical testing, hydrodynamic measurements and in vitro human mesenchymal stem cell (hMSC) adhesion (4 h), proliferation (1, 3 and 5 d) and osteogenic differentiation (1, 2 and 3 weeks). These tests confirmed bone-like physical properties and vascular-like flow profiles, as well as demonstrated enhanced hMSC adhesion, proliferation and osteogenic differentiation. Additional in vitro experiments with human umbilical vein endothelial cells also demonstrated improved vascular cell growth, migration and organization on micro-nano featured scaffolds.

The evolution of a short injection-hole jet issuing into a crossflow at low blowing ratios is presented. Particle image velocimetry (PIV) is used to determine structural features of the jet/crossflow interaction throughout its development from within the jet supply channel (which feeds the holes), through the injection hole, and into the crossflow. The effect of supply channel feed orientations, i.e. counter to, or in the same direction as the crossflow is emphasized. Feed orientation profoundly affects such jet characteristics as trajectory and lateral spreading, as well as its structural features. Fluid within the high-speed supply channel exhibits swirling motions similar to the flow induced by a pair of counter-rotating vortices. The sense of rotation of the swirling fluid depends upon the orientation of the supply channel flow with respect to the crossflow, and in turn impacts the in-hole velocity fields. In the coflow supply channel geometry (channel flow is in the same direction as the free stream), a pair of vortices exists within the hole with the same sense of rotation as the primary jet counter-rotating vortex pair (CRVP). In contrast, the counterflow supply channel configuration has in-hole vortices of opposite rotational sense to that of the CRVP. The in-hole vortices interact constructively or destructively with the CRVP, thus affecting the strength and coherence of the CRVP. The counterflow configuration has a weakened CRVP because of destructive interference with the in-hole vortices. The weaker CRVP has a lower trajectory and increased spanwise spreading. External to the injection hole, a pair of vortices exists immediately downstream of the jet. They are initially perpendicular to the boundary-layer plate near the wall and are outboard of the streamwise hole centreline. These vortices, denoted ‘downstream spiral separation node’ (DSSN) vortices, are affected by both the supply channel feed direction and the blowing ratio. They appear to form by free-stream fluid wrapping around the jet and interacting with the CRVP. The coflow supply channel geometry is associated with the largest and most well-defined DSSN vortices, and their size is inversely proportional to the blowing ratio. At low blowing ratio, these vortices induce a large recirculating flow region downstream of the injection hole at the wall.