Covering: 1990 to 2010 This is a review of anticancer agents isolated from endophytic fungi from 1990–2010. Endophytic fungi are defined as fungi that live asymptomatically within the tissues of higher plants. The designation ‘anticancer’ is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines. Many of the compounds reported here were isolated exclusively from endophytes in culture, while other compounds had been previously reported as chemical constituents of higher plants. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity, or as an alternative source of compounds originally isolated from higher plants. Endophytes represent a dependable source of specific secondary metabolites, and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

This is a review of bioactive secondary metabolites isolated from conifer-associated endophytic fungi from 1990-2014. This includes compounds with antimicrobial, anti-inflammatory, anti-proliferative and cytotoxic activity towards human cancer cell lines, and activity against either plant pathogens or plant insect pests. Compounds that were originally reported without associated activity were included if other studies ascribed activity to these compounds. Compounds were not included if they were exclusively phytotoxic or if they were isolated from active extracts but were not determined to be the active component of that extract.