The study block is located on the eastern edge of the Ordos Basin and is one of the typical medium coalbed methane blocks in China that have previously been subjected to exploration and development work. The rich CBM resource base and good exploration and development situation in this block mean there is an urgent need to accelerate development efforts, but compared with the current situation for tight sandstone gas where development is in full swing in the area, the production capacity construction of CBM wells in the area shows a phenomenon of lagging to a certain degree. In this study, taking the 4 + 5 coal seam of the YJP block in the Ordos Basin as the research object, we carried out technical research on an integrated program concerning CBM geology and engineering and put forward a comprehensive seismic geology analysis method for the prediction of the CBM content. The study quantitatively assessed the tectonic conditions, depositional environment, and coal seam thickness as potential controlling factors using gray relationship analysis, trend surface analysis, and seismic geological data integration. The results show that tectonic conditions, especially the burial depth, residual deformation, and fault development, are the main controlling factors affecting the coalbed methane content, showing a strong correlation (gray relational value greater than 0.75). The effects of the depositional environment (sand–shale ratio) and coal bed thickness were negligible. A weighted fusion model incorporating seismic attributes and geological parameters was developed to predict the gas content distribution, achieving relative prediction errors of below 15% in validation wells, significantly outperforming traditional interpolation methods. The integrated approach demonstrated enhanced spatial resolution and accuracy in delineating the lateral CBM distribution, particularly in structurally complex zones. However, limitations persist due to the seismic data resolution and logging data reliability. This method provides a robust framework for CBM exploration in heterogeneous coal reservoirs, emphasizing the critical role of tectonic characterization in gas content prediction.