Most automatic expression analysis systems attempt to recognize a small set of prototypic expressions, such as happiness, anger, surprise, and fear. Such prototypic expressions, however, occur rather infrequently. Human emotions and intentions are more often communicated by changes in one or a few discrete facial features. In this paper, we develop an automatic face analysis (AFA) system to analyze facial expressions based on both permanent facial features (brows, eyes, mouth) and transient facial features (deepening of facial furrows) in a nearly frontal-view face image sequence. The AFA system recognizes fine-grained changes in facial expression into action units (AU) of the Facial Action Coding System (FACS), instead of a few prototypic expressions. Multistate face and facial component models are proposed for tracking and modeling the various facial features, including lips, eyes, brows, cheeks, and furrows. During tracking, detailed parametric descriptions of the facial features are extracted. With these parameters as the inputs, a group of action units (neutral expression, six upper face AU and 10 lower face AU) are recognized whether they occur alone or in combinations. The system has achieved average recognition rates of 96.4 percent (95.4 percent if neutral expressions are excluded) for upper face AU and 96.7 percent (95.6 percent with neutral expressions excluded) for lower face AU. The generalizability of the system has been tested by using independent image databases collected and FACS-coded for ground-truth by different research teams.

The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.

We demonstrate a method that merges the quantum filter diagonalization (QFD) approach for hybrid quantum-classical solution of the time-independent electronic Schrödinger equation with a low-rank double factorization (DF) approach for the representation of the electronic Hamiltonian. In particular, we explore the use of a novel sparse “compressed” double factorization (C-DF) truncation of the Hamiltonian within the time-propagation elements of QFD, while retaining a similarly compressed but numerically converged double-factorized representation of the Hamiltonian for the operator expectation values needed in the QFD quantum matrix elements. The new C-DF method is found to provide substantial additional compression at any given accuracy metric over the traditional “explicit” double factorization approach. Together with significant circuit reduction optimizations and number-preserving postselection and echo-sequencing error mitigation strategies, the method is found to provide accurate predictions for low-lying eigenspectra in a number of representative molecular systems, while requiring reasonably short circuit depths and modest measurement costs. The method is demonstrated by experiments on noise-free simulators, simulations including models of decoherence and shot-noise, and real quantum hardware.