Tiziana Mifsud

Dr. Tiziana Mifsud

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 March 2023 in Journal of Biomechanics
Verified
Journal Article
Open access
TMTiziana Mifsud
Tiziana Mifsud
PCPanagiotis E. Chatzistergos
Panagiotis E. Chatzistergos
CMConstantinos Maganaris
Constantinos Maganaris
NCNachiappan Chockalingam
Nachiappan Chockalingam
NPNat Padhiar
Nat Padhiar
AGAlfred Gatt
Alfred Gatt
Supersonic shear wave (SW) elastography has emerged as a useful imaging modality offering researchers and clinicians a fast, non-invasive, quantitative assessment of tendon biomechanics. However, the exact relationship between SW speed and in vivo tendon stiffness is not intuitively obvious and needs to be verified. This study aimed to explore the validity of supersonic SW elastography against a gold standard method to measure the Achilles tendon's in vivo tensile stiffness by combining conventional ultrasound imaging with dynamometry. Twelve healthy participants performed maximal voluntary isometric plantarflexion contractions (MVC) on a dynamometer with simultaneous ultrasonographic recording of the medial gastrocnemius musculotendinous junction for dynamometry-based measurement of stiffness. The tendon's force-elongation relationship and stress-strain behaviour were assessed. Tendon stiffness at different levels of tension was calculated as the slope of the stress-strain graph. SW speed was measured at the midportion of the free tendon and tendon Young's modulus was estimated. A correlation analysis between the two techniques revealed a statistically significant correlation for small strains (r(10) = 0.604, p =.038). SW-based assessments of in vivo tendon stiffness were not correlated to the gold standard method for strains in the tendon>10 % of the maximum strain during MVC. The absolute values of SW-based Young's modulus estimations were approximately-three orders of magnitude lower than dynamometry-based measurements. Supersonic SW elastography should be only used to assess SW speed for the detection and study of differences between tissue regions, differences between people or groups of people or changes over time in tendon initial stiffness (i.e., stiffness for small strains).

28 April 2025 in The Foot
Verified
Journal Article
Open access
TMTiziana Mifsud
Tiziana Mifsud
AGAlfred Gatt
Alfred Gatt
NCNachiappan Chockalingam
Nachiappan Chockalingam
KSKirill Micallef Stafrace
Kirill Micallef Stafrace
NPNat Padhiar
Nat Padhiar
Achilles tendinopathy is a common overuse injury among athletes, classified into mid-portion and insertional types. While existing literature primarily emphasizes mid-portion tendinopathy as the more prevalent form, emerging evidence highlights the significance of insertional tendinopathy. Variations in clinical presentation warrant further investigation, particularly regarding anatomical differences that could inform treatment strategies and rehabilitation protocols. This study aimed to assess the prevalence of Achilles tendon pathologies and explore anatomical differences in the length of the free tendon between insertional and mid-portion tendinopathy. This study represents a cross-sectional analysis conducted as part of a larger longitudinal study on the mechanical properties of patients with Achilles tendinopathy. A total of 103 patients (38.8 % males, 61.2 % females, age: 53 ± 12.8 years, body Mass Index (BMI): 30 ± 7.4 kg/m2, 60 % sedentary while 40 % active) diagnosed with Achilles tendon pathologies from across the Maltese islands were recruited for ultrasound assessments to measure tendon length and evaluate associated anatomical characteristics. Participants were categorised based on the type of tendinopathy. A higher prevalence of insertional tendinopathy (67.9 %) was identified compared to mid-portion tendinopathy (20.3 %). Notably, participants with insertional tendinopathy presented with short tendons (3.8 ± 1.4 cm, p = <0.001) compared to those with longer free tendon length in mid-portion tendinopathy (5.9 ± 1.3 cm, p = <0.001). This anatomical distinction, along with the lower attachment of the soleus muscle, may contribute to differing biomechanical properties, influencing the risk of specific tendon pathologies. This study is the first to report a higher prevalence of insertional tendinopathy and to highlight the link between short free tendon length and insertional tendinopathy. This emphasizes the importance of monitoring short free tendons, as they are likely pivotal in the development of insertional tendinopathy.

1 February 2025 in Bioengineering
Verified
Journal Article
Open access
PDF file
MBMark Borg
Mark Borg
SMStpehen Mizzi
Stpehen Mizzi
RFRobert Farrugia
Robert Farrugia
TMTiziana Mifsud
Tiziana Mifsud
AMAnabelle Mizzi
Anabelle Mizzi
OFOwen Falzon
Owen Falzon
Monitoring plantar foot temperatures is essential for assessing foot health, particularly in individuals with diabetes at increased risk of complications. Traditional thermographic imaging measures foot temperatures in unshod individuals lying down, which may not reflect thermal characteristics of feet in shod, active, real-world conditions. These controlled settings limit understanding of dynamic foot temperatures during daily activities. Recent advancements in wearable technology, such as insole-based sensors, overcome these limitations by enabling continuous temperature monitoring. This study leverages a data-driven clustering approach, independent of pre-selected foot regions or models like the angiosome concept, to explore normative thermal patterns in shod feet with insole-based sensors. Data were collected from 27 healthy participants using insoles embedded with 21 temperature sensors. The data were analysed using clustering algorithms, including k-means, fuzzy c-means, OPTICS, and hierarchical clustering. The clustering algorithms showed a high degree of similarity, with variations primarily influenced by clustering granularity. Six primary thermal patterns were identified, with the “butterfly pattern” (elevated medial arch temperatures) predominant, representing 51.5% of the dataset, aligning with findings in thermographic studies. Other patterns, like the “medial arch + metatarsal area” pattern, were also observed, highlighting diverse yet consistent thermal distributions. This study shows that while normative thermal patterns observed in thermographic imaging are reflected in insole data, the temperature distribution within the shoe may better represent foot behaviour during everyday activities, particularly when enclosed in a shoe. Unlike thermal imaging, the proposed in-shoe system offers the potential to capture dynamic thermal variations during ambulatory activities, enabling richer insights into foot health in real-world conditions.

29 March 2026 in Sensors
Verified
Journal Article
Open access
PDF file
SMStpehen Mizzi
Stpehen Mizzi
TMTiziana Mifsud
Tiziana Mifsud
AMAnabelle Mizzi
Anabelle Mizzi
MBMark Borg
Mark Borg
RFRobert Farrugia
Robert Farrugia
OFOwen Falzon
Owen Falzon
This study aimed to establish normative in-shoe plantar foot temperature patterns across three static postures—lying, sitting, and standing—in healthy individuals, providing a clinically relevant baseline for interpreting in-shoe thermograms in diabetic or peripheral arterial disease (PAD) populations. A single-center prospective study included 20 healthy adults (40 limbs; 22–74 years) who underwent vascular and neurological screening prior to data collection. Plantar temperature was continuously recorded using Tarsos® Smart Insoles with 21 embedded sensors per foot during three consecutive 10 min phases: supine, sitting, and standing. Data were analyzed for regional differences across the toes, metatarsals, arch, and heel using statistical and visual methods. Distinct posture-related temperature patterns were observed. The arch consistently exhibited the highest temperatures, while the toes remained cooler across all phases. Supine positioning resulted in relatively uniform temperature increases, whereas sitting and standing demonstrated more-stable but region-specific patterns, with slower rates of temperature change and more pronounced regional variation. Compared with barefoot thermography, the in-shoe condition showed greater heat retention and reduced evaporative cooling, highlighting the importance of context-specific baseline data. These findings demonstrate the influence of posture on plantar thermal distribution in the in-shoe environment and support the use of embedded monitoring systems for continuous assessment where surface thermography is not feasible.