Prostate cancer (PCa) is one of the most common tumors diagnosed in men worldwide, with approximately 1.7 million new cases expected by 2030. Most cancerous lesions in PCa are located in the peripheral zone (PZ); therefore, accurate identification of the location of the lesion is essential for effective diagnosis and treatment. Zonal segmentation in magnetic resonance imaging (MRI) scans is critical and plays a key role in pinpointing cancerous regions and treatment strategies. In this work, we report on the development of three advanced neural network-based models: one based on ensemble learning, one on Meta-Net, and one on YOLO-V8. They were tailored for the segmentation of the central gland (CG) and PZ using a small dataset of 90 MRI scans for training, 25 MRIs for validation, and 24 scans for testing. The ensemble learning method, combining U-Net-based models (Attention-Res-U-Net, Vanilla-Net, and V-Net), achieved an IoU of 79.3% and DSC of 88.4% for CG and an IoU of 54.5% and DSC of 70.5% for PZ on the test set. Meta-Net, used for the first time in segmentation, demonstrated an IoU of 78% and DSC of 88% for CG, while YOLO-V8 outperformed both models with an IoU of 80% and DSC of 89% for CG and an IoU of 58% and DSC of 73% for PZ.

Background: Orthodontically induced external root resorption (ERR) may affect long-term tooth stability, requiring a reliable assessment of root length changes. This study developed an artificial intelligence (AI)-based framework for automatic segmentation and quantitative evaluation of root resorption, comparing fixed appliances and clear aligner therapy. Methods: A dataset of 100 anonymised orthopantomographic (OPG) radiographs (50 fixed appliance, 50 clear aligner) obtained before and after orthodontic treatment was analysed. A U-Net model was trained for automatic tooth segmentation and quantitative assessment of tooth length changes. Measurements were computed from both AI-predicted and Dentist-annotated masks using pixel-based Python analysis (Python version 3.6), and pre-post differences were compared between methods. Results: The segmentation model achieved high performance with Intersection over Union values up to 89% and Dice Similarity Coefficients up to 95%. Quantitative analysis demonstrated significant reductions in root length following orthodontic treatment in both modalities (p < 0.0001). In the fixed appliance group, AI-based measurements showed an average root length reduction of 8.95%, while human measurements indicated a reduction of 10.16%. In the clear aligner group, AI measurements demonstrated a reduction of 2.81%, compared with 4.98% in human measurements. Root resorption was significantly greater in the fixed appliance group than in the clear aligner group (p < 0.0001). AI-derived measurements showed strong agreement with expert evaluations. Conclusions: AI-based analysis of panoramic radiographs may provide a reliable and reproducible approach for quantifying orthodontically induced root resorption. The findings suggest that clear aligner therapy was associated with lower root length reduction; however, larger multi-centre studies and external validation are required before clinical implementation.

Accurate classification of clinically significant prostate cancer remains a major challenge. While multiparametric MRI (mpMRI) has improved lesion detection, effective categorization in accordance to the Prostate Imaging Reporting and Data System (PI-RADS) remains complex. In this study, we propose and evaluate three complementary approaches for automated PI-RADS classification differing in the way in which the features are extracted from the mpMRI imaging sequences. The first approach extracts hand-crafted radiomic features from manually segmented lesions using the PyRadiomics library. The second approach extends this by integrating fully automated lesion and zonal segmentation to simulate a real-world, manual-free pipeline. The third approach utilizes a custom convolutional neural network (CNN) to learn high-level features images and lesion masks directly. The images come from Apparent diffusion coefficient (ADC), diffusion-weighted imaging (DWI), and T2-weighted (T2W) imaging. The features issued by the three methods were used to train a set of machine learning models for multi-class PI-RADS classification, specifically targeting the clinically relevant categories 3, 4, and 5. Results show that ADC-derived features consistently yield superior performance, with one of the ensemble models reaching an AUC of 0.83. Combining features across all sequences further improved robustness (AUC = 0.84). PI-RADS 5 classification was most reliable (AUC ≥ 0.94), whereas PI-RADS 3 remained the most difficult to distinguish. Our findings highlight the effectiveness of ADC features and the advantage of combining automated and deep learning-based strategies for robust prostate cancer risk stratification.

**Abstract text** Background: Prostate cancer (PC) is the most common cancer in western countries with an incidence of 10-15%. Fortunately, the e | POSTER