To estimate the pooled risk of coffee consumption for Alzheimer's disease (AD). We have reviewed all observational studies that evaluated the association between AD risk and coffee consumption. Four studies were identified: two case-control studies and two cohorts. These studies were carried out between 1990 and 2002. There was an obvious protective effect of coffee consumption in the pooled estimate [risk estimate: 0.73 (95% confidence interval: 0.58-0.92)]. However, the homogeneity test was highly significant (p<0.01), indicating heterogeneity across the pooled studies. Pooled analysis applying the random effect model was 0.79 with 95% confidence interval overlapping unity (95% confidence interval: 0.46-1.36). Three studies assessed coffee consumption by interview questionnaire. The risk of AD in coffee consumers versus non-consumers in studies that used interview questionnaire had a pooled risk estimate of 0.70 with 95% confidence interval 0.55-0.90. Although our pooled estimates show that coffee consumption is inversely associated with the risk of AD, the four studies had heterogeneous methodologies and results. Further prospective studies evaluating the association between coffee consumption and AD are strongly needed.

Perhaps one of the most important questions posed by the neurobiology of aging concerns the pathogenic mechanisms in Parkinson's disease (PD). Recently, it was suggested that exposure to pesticides could be the main cause of PD. Another study reported that the environmental endotoxin, lipopolysaccaride produced by Salmonella minnesota, might be a risk factor for PD. An alternative explanation is the genetic component, which has been suggested to be an important risk factor. Epidemiological studies have identified a positive family history of Parkinson as one of the most important risk factors for the disease. However, these studies neither examined nor reviewed the medical records of the family members. The twin study stated that the major factors in the etiology of PD are non-genetic. Meanwhile, epidemiological studies from China have shown that the prevalence of PD is much lower than in the Caucasian population, explained by the low frequency of cytochrome P-450 CYP2D6 debrisoquine hydroxylase gene polymorphism. The etiology of idiopathic PD is still a question for scientists, and calls for further research, especially with the growing proportion of elderly and the rising incidence of PD worldwide. Future research for PD risk factors should consider that multiple interactions occur in PD, resulting in a complex trait, which includes genetic, acquired, and environmental components.

Purpose: To evaluate the risk of PD associated with tea consumption. Material and Methods: We reviewed all observational studies that evaluated the association between PD risk and tea consumption. Only, 12 studies were identified: 11 case-control and 1 cohort. These studies were carried out between 1981 and 2003. The studies represented different populations from 3 continents; North America, Europe and Asia. The 3 studies from Asia were case-control studies of Chinese populations. Results: There was a clear protective effect of tea consumption in the pooled risk estimate [OR: 0.83 (95% confidence interval 0.74 to 0.92)] with 2215 cases and 145578 controls. However, the homogeneity test was significant (p value of 0.008), denoting heterogeneity across the pooled studies. Pooled analysis applying the random effect model was OR: 0.81 with 95% confidence interval nearly overlapping unity (95% confidence interval 0.67 to 0.98). Tea consumers versus non-consumers in Chinese populations had pooled OR of 0.73 with 95% confidence interval 0.60 to 0.90 (470 cases and 623 controls). The p value of homogeneity test was 0.96, denoting homogeneity across the pooled 3 studies. Conclusion: Tea consumption can protect against PD and this protective effect is clearer in Chinese populations. The low rate of tea consumption among persons with PD should provide us many valuable insights into the nature of the illness.

Ilizarov technique is useful in the management of infected nonunions of the tibia. Its main drawback is the long duration of external fixation (EF) with marked patient discomfort. Several techniques have been described for early removal of EF to avoid this problem. Between September 2000 and October 2001, a prospective study at a tertiary trauma center was performed. Thirty-three patients with infected nonunion of the tibial shaft were included. The eradication of infection was by debridement, followed by limb reconstruction using segment transport technique with Ilizarov EF system. When the transported segment reached the docking site, we offered the patients removal of EF, and replacement by intramedullary (I M) fixation with bone graft at the docking site. Advantages and risks were explained to all patients. Patients (N = 17) who accepted this technique were compared with patients (N = 16) who preferred to continue in EF till full bone union, with bone graft at the docking site used in both groups. Mean age of the patients was 29 years, and mean duration of nonunion was 12.6 (range, 6-22) months. Average duration of follow-up from the date of presentation was 36 (range, 22-48) months. Main outcome measurements were assessment of bone and functional outcome using the classification of the Association for the Study and Application of the Method of Ilizarov, EF index, radiographic consolidation index, healing time, duration of EF, and complications The average duration of EF in the first group was 3.1 month, meanwhile in the second group it was 8.5 months. The Association for the Study and Application of the Method of Ilizarov bony and functional outcome assessment score showed no statistically significant difference between the two techniques on follow-up. Early removal of EF and replacement by intramedullary nail can achieve complete healing for infected nonunion of the tibial shaft with shorter duration of EF; nearly one-third the usual duration of EF and give the same functional and bony outcome as the classic technique. It is a relatively safe technique but the risk of infection recurrence must be explained to the patient.

Over the last decade, the possible association between underarm deodorants/ antiperspirants use and breast cancer risk has raised important interest in the scientific community. The objective of our systematic review is to estimate the pooled risk of deodorants/antiperspirants use for breast cancer. All observational studies that evaluated the association between breast cancer risk and deodorants/antiperspirants use were reviewed. We have only identified two case-control studies, carried out between 2002 and 2006. The first study was conducted in USA and investigated the possible relationship between use of products applied for underarm perspiration and the risk for breast cancer in women aged 20-74 years. This population-based case-control study gathered information by in-person interview. The second study was conducted in Iraq and investigated the possible relationship between use of antiperspirants and the risk for breast cancer in women attending a teaching hospital. This study also gathered information by in-person interview. There was no risk of antiperspirants use in the pooled risk (odds ratio 0.40, 95% confidence interval 0.35-0.46). Our comprehensive search has identified an insufficient number of studies to conduct a quantitative review and obtain reliable results. Further prospective studies are strongly needed.