José Enrique Hernández-Rodríguez

Dr. José Enrique Hernández-Rodríguez

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 February 2025 in Medicina
Verified
Journal Article
Open access
PDF file
Pedro Raúl Castellano-SantanaPedro Raúl Castellano-Santana
Pedro Raúl Castellano-Santana
FCFrancisco Cabrera-López
Francisco Cabrera-López
MMMaría-DeLasNieves Martín-Alonso
María-DeLasNieves Martín-Alonso
YFYésica Flores-Jardo
Yésica Flores-Jardo
JGJesús González-Martín
Jesús González-Martín
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
Background and Objectives: Retinal detachment is a severe ophthalmological condition requiring urgent surgical intervention and comprehensive postoperative management. This study aimed to evaluate the impact of perceived social support (PSS) on postoperative adherence, pain management, and reintervention rates in patients undergoing retinal detachment surgery. It was hypothesized that higher levels of PSS would be associated with better postoperative outcomes, particularly in adherence and anxiety management. Materials and Methods: A prospective observational study was conducted with 166 patients at a tertiary hospital between 2022 and 2024. Sociodemographic and clinical data were collected, and PSS was assessed using the Medical Outcomes Study (MOS) questionnaire (Cronbach’s alpha = 0.96). The primary outcomes included adherence to postoperative recommendations, reintervention rates, additional analgesic use, and local complications. Given the non-normal distribution of key variables, non-parametric statistical analyses were performed, with significance set at p < 0.05. Results: PSS scores were consistently high (median: 5; IQR: 4.7–5.0). Adherence rates were excellent (100% at 7 and 15 days; 99.04% at 30 days). Reintervention rates remained low (0.5%, 1.0%, and 1.5% at 7, 15, and 30 days, respectively). The need for additional analgesia decreased significantly over time (46.43% at 7 days vs. 13.33% at 30 days; p = 0.041). Preoperative anxiety was significantly associated with higher postoperative analgesic consumption (median STAI score: 38 [IQR: 34–42], p = 0.041). A significant relationship was found between higher preoperative anxiety levels and greater postoperative analgesic use (p = 0.041). However, no significant associations were found between PSS and major clinical outcomes such as reintervention or complications. Conclusions: These findings suggest that PSS may influence adherence to postoperative recommendations, although its direct impact on clinical outcomes remains uncertain. The significant association between higher preoperative anxiety and increased postoperative analgesic consumption highlights the need for psychosocial and educational interventions in RD surgical care. These results support a multidisciplinary approach incorporating psychosocial support alongside surgical treatment to optimize patient outcomes.

26 June 2025 in Pharmaceutics
Verified
Journal Article
Open access
PDF file
JGJosé Manuel Pérez Galván
José Manuel Pérez Galván
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
JMJose Luis Martín-Barrasa
Jose Luis Martín-Barrasa
MMMaximina Monzón-Mayor
Maximina Monzón-Mayor
PSPedro Saavedra
Pedro Saavedra
MRMaría del Mar Romero-Alemán
María del Mar Romero-Alemán
Background/Objectives: The utility of various biocompatible biological and synthetic polymers as substrates to provide structural support, facilitate cell migration, and promote the healing of full-thickness wounds by secondary intention has been studied. This includes intelligent structures that enable the release of natural products or drugs for these and other purposes. In this study, the primary objective was to analyze and compare, from a macroscopic perspective, the individual behavior of the polymer poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), with Aloe vera (PHBV/Av) or honey (PHBV/Ho), in the healing process of a full-thickness skin wound over 40 days in a murine model, in addition to describing the microscopic ultrastructure of the nanofibers. Methods: Two experimental groups were established, PHVB/AV (n = 5) and PHVB/Ho (n = 5), along with one control group, PHBV (n = 5), all of which underwent biopsies that included the entire thickness of the skin and the panniculus carnosus of the mid-dorsal area of the mouse. Cylindrical pieces of each membrane, measuring approximately 7 × 0.2 mm, were placed in the wound bed and covered with a transparent dressing. No topical treatment was administered during the control process, nor were the implants changed during the healing period. Results: Univariate and multivariate analyses were performed. The data show that the PHBV/Ho scaffolds reduce the diameter of the wounds by 100% after 40 days (p < 0.001), compared with PHBV/Av (100%; p = 0.211) and the control group, PHBV. Conclusions: From a macroscopic perspective, the PHBV/Ho scaffold significantly accelerated wound healing when applied once to the wound bed, outperforming both the PHBV/Av composite and PHBV alone. Notably, this effect was achieved without the need for dressing changes or additional treatment during the healing period.

15 November 2023 in The International Journal of Lower Extremity Wounds
Verified
Journal Article
Closed access
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
JMJosé Luis Martín-Barrasa
José Luis Martín-Barrasa
JAJ. Aragón-Sánchez
J. Aragón-Sánchez
MMMaximina Monzón-Mayor
Maximina Monzón-Mayor
JPJosé Manuel Pérez-Galván
José Manuel Pérez-Galván
MRMaría del Mar Romero-Alemán
María del Mar Romero-Alemán
Chronic ulcers are a major health problem associated with high costs and a loss of quality of life. Because of this, the search for products that accelerate wound healing is a constant, given the need for alternatives that help to alleviate this serious health problem. We analyzed the efficacy of 2 natural products—honey and aloe vera—versus hydrocolloid (HC) dressings as a control group in healing full-thickness wounds. For this purpose, we performed full-thickness excisions of the skin, including the panniculus carnosus , in mice. We inserted a nitrile ring into the subcutaneous cellular tissue simulating the second-intention wound healing course. We found that aloe vera reduced the diameter of the wounds compared to honey ( p < .001) and the control group ( p < .001).

20 October 2023 in Medicine
Verified
Journal Article
Open access
FCFernando Calvo-Francés
Fernando Calvo-Francés
LCLucía Cilleros-Pino
Lucía Cilleros-Pino
PBPaula Andrea Barraza-Illanes
Paula Andrea Barraza-Illanes
MDMaximino Díaz-Hernández
Maximino Díaz-Hernández
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
There is an urgent need for generalized training in cardiopulmonary resuscitation (CPR) techniques, starting with secondary education. Validated instruments for assessing the efficacy of such interventions are not yet available. This study aimed to validate an evaluation questionnaire of a CPR training program for high school students, to analyze the levels of readability, difficulty, reliability, and content validity, as well as the fit the purpose for which they were designed, the trait they are intended to measure. An instrumental study was conducted in 2 phases. In the first phase, an inter-judge validation was carried out with 11 experts in CPR accredited instructors of basic and advanced CPR by the American Heart Association. In the second phase, the psychometric properties were evaluated from the perspective of Item Response Theory. During May of the 2017/18 and 2018/19 academic years, 259 4th-year secondary school students from a high school in the southeastern area of the island of Gran Canaria (mean age: 15.78 years; 50.60% male) were surveyed anonymously using the questionnaire to be validated. The questionnaire was easily readable (74.12 Flesch-Szigriszt Index); the difficulty level (Easy/Very Easy) in the context of this secondary school level of education and the ability level of the respondents overlapped sufficiently and there was no gender bias. The questionnaire was able to discriminate between respondents of slightly more than 7 levels of expertise, from low knowledge of CPR to high knowledge of CPR (Separation Index 7.53). The model fit was excellent (infit = 1/outfit = 1.01). The content validity index was adequate. The separation index and reliability exceeded what was considered adequate for guaranteed use. The level of difficulty of the items and the level of ability of the respondents is in line with the educational level of the students. The questionnaire did not produce a gender bias in response probability. The questionnaire is easily understandable and can discriminate between different levels of ability without differential gender bias, and its reliability is outstanding, as it exceeds the minimum criteria.

3 June 2025 in Preprints.org
Verified
Preprint
Open access
PDF file
JGJosé Manuel Pérez Galván
José Manuel Pérez Galván
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
JMJose Luis Martín-Barrasa
Jose Luis Martín-Barrasa
MMMaximina Monzón-Mayor
Maximina Monzón-Mayor
PSPedro Saavedra
Pedro Saavedra
MRMaria-Del-Mar Romero-Aleman
Maria-Del-Mar Romero-Aleman
Background/Objectives: The utility of various biocompatible biological and synthetic polymers has been studied as substrates to provide structural support, facilitate cell migration, and promote the healing of full-thickness wounds by secondary intention. This includes intelligent structures that enable the release of natural products or drugs for these and other purposes. In this study, the primary objective was to analyze and compare, from a macroscopic perspective, the individual behavior of the different polymers in the healing process of a full-thickness skin wound over 40 days in a murine model, in addition to describing the main characteristics of nanofibers and their microscopic ultrastructure. Methods: Two experimental groups were established, PHVB/AV (n=5) and PHVB/Ho (n=5), along with one control group (PHBV) (n=5), all of which underwent biopsies that included the entire thickness of the skin and the panniculus carnosus of the mid-dorsal area of the mouse. Cylindrical pieces of each membrane, measuring approximately 7 x 0.2 mm, were placed in the wound bed and covered with a transparent dressing. No topical treatment was administered during the control process, nor were the implants changed during the healing period. Results: Univariate and multivariate analyses were performed. The data show that the PHBV-Ho matrices reduce the diameter of the wounds by 100% after 40 days (p < 0.001), compared to PHBV-Av polymers (100%; p< 0.211) and the control group (68.8%). Conclusions: From a macroscopic perspective, the PHBV/Ho polymer significantly accelerated wound healing when applied once to the wound bed, outperforming both the PHBV/AV composite and PHBV alone. Notably, this effect was achieved without the need for dressing changes or additional treatment during the healing period.

9 January 2026 in Teaching and Learning in Nursing
Verified
Journal Article
Open access
Pedro Raúl Castellano-SantanaPedro Raúl Castellano-Santana
Pedro Raúl Castellano-Santana
MAMaría del Carmen Agüera-Bolea
María del Carmen Agüera-Bolea
JAJavier Alonso-Fernández
Javier Alonso-Fernández
JHJosé Enrique Hernández-Rodríguez
José Enrique Hernández-Rodríguez
MDMaximino Díaz-Hernández
Maximino Díaz-Hernández
MPManuel Pardo-Ríos
Manuel Pardo-Ríos