The world has changed forever as a result of the COVID-19 pandemic. Antimicrobial resistance is a primary global health concern that places a significant financial and health burden on nations. Patients with Campylobacter-caused infections were the subject of the retrospective investigation. The data show that children aged 1–6 are the most commonly affected by Campylobacter enteritis. Resistance levels fluctuated over the course of the two periods. Nine isolates were sensitive to macrolides, and only one was responsive to tetracycline, which indicated inadequate sensitivity across all classes throughout the pandemic. This pattern raises serious concerns about the potential impact on public health. Tetracyclines and fluoroquinolones rank highest in terms of bacterial resistance. Regardless of the species, macrolides remain a practical and sufficient treatment for Campylobacter enteritis. Reassurance is still provided by much lower numbers in the post-pandemic period. There is no evidence to support the alarming claims made in the international literature about macrolides in Romania.

Background: Sepsis is a life-threatening organ dysfunction that results from an exaggerated host immune response to disseminated infection. The relationship between lymphopenia and sepsis has been extensively studied, and in particular, sepsis-induced lymphopenia is gradually being recognized as an essential factor in the prognosis of sepsis. Notably, sepsis-induced lymphopenia has been associated with worse outcomes, including increased risk of secondary infections, multiple organ failure, and death. Few studies have directly compared the dynamic evolution of lymphocyte counts between different etiologies of sepsis or evaluated their prognostic value using serial measurements. This study aims to explore the temporal dynamics of lymphopenia, but also of neutrophil-to-lymphocyte (NLR) ratio in patients with severe systemic infections and to assess their relationship with in-hospital mortality. Methods: A prospective cohort of 95 adult patients was analyzed. Absolute lymphocyte counts (ALCs) and neutrophil-to-lymphocyte (NLR) ratio values were recorded on Days 1, 3, 5, and 7. Comparisons were made between different infectious etiologies and outcomes, and ROC analysis assessed predictive performance. Results and Conclusions: Patients with viral sepsis (“COVID-19”) showed a significant and sustained decrease in lymphocyte counts (p < 0.001) and a progressive increase in NLR (p < 0.001), unlike patients with bacterial sepsis. In correlation with outcome, regardless of etiology, lymphocyte counts were significantly lower in non-survivors from Day 3 onward, while NLR was significantly higher on Day 7 (p = 0.002). Early NLR and ALC had limited predictive value, but longitudinal trends were associated with poor prognosis.

Introduction: Staphylococcus are gram-positive bacteria that inhabit both the skin and mucous membranes of both humans and animals. Antimicrobial susceptibility testing is one of the most important laboratory procedures for infectious disease management. Material and method: Between January 2017 and June 2019, in the Clinical Infectious Diseases Hospital (CIDH) of Constanta, 331 strains of staphylococcus isolated from various pathological products were identified and tested for antibiotic sensitivity: urine culture, stool culture, pharyngeal / nasal discharge, blood culture, sputum, vomiting fluid and various secretions. Results: During 2017, 95 strains were isolated from patients hospitalized in CIDH, in 2018: 118, and in the first half of 2019: 124 staphylococcal strains. An analysis by age groups shows that staphylococcus infection predominates in adults with a total of 196 (59.21%), and in children, less than 18 years: 135 (40.78%). Of the 196 adults, there are immunocompetent patients: 115 (58.67%), immunocompromised by HIV 40 (20.50%), and 19 were hospitalized in the intensive care unit (9.69%). Regarding the predominant sex in staph infections, the most strains were registered in males: 179 (54.07%) and 152 in females (45.92%). Out of the total strains of isolated Staphylococcus, 160 (48.33%) of Staphylococcus aureus were identified, of which methycillin resistant staphylococcus aureus (MRSA) 43 (26.87%). Testing for Staphylococcus aureus strains with Oxacillin showed that 45 (28.12%) were resistant, Rifampicin 26 (16.25%) was resistant, Fluoroquinolones 29 (18.12%), and Cotrimoxazole / Sulfamethoxazole 27 (16.87%) of the strains were resistant. Conclusions: There is a relatively high resistance to Oxacillin of Staphylococcus aureus strains and a relatively low resistance to fluoroquinolones, Rifampicin and Cotrimoxazole / Sulfamethoxazole, over the years studied.