The rapid increase in the number of stimuli-responsive polymers, also known as smart polymers, has significantly advanced their applications in various fields. These polymers can respond to multiple stimuli, such as temperature, pH, solvent, ionic strength, light, and electrical and magnetic fields, making them highly valuable in both the academic and industrial sectors. Recent studies have focused on developing hydrogels with self-healing properties that can autonomously recover their structural integrity and mechanical properties after damage. These hydrogels, formed through dynamic covalent reactions, exhibit superior biocompatibility, mechanical strength, and responsiveness to stimuli, particularly pH changes. However, conventional hydrogels are limited by their weak and brittle nature. To address this, ionizable moieties within polyelectrolytes can be tuned to create ionically cross-linked hydrogels, leveraging natural polymers such as alginate, chitosan, hyaluronic acid, and cellulose. The integration of ionic liquids into these hydrogels enhances their mechanical properties and conductivity, positioning them as significant self-healing agents. This review focuses on the emerging field of stimuli-responsive ionic-based hydrogels and explores their potential in dermal applications and tissue engineering.

Nanofibers fabricated from various materials such as polymers, carbon, and semiconductors have been widely used for wound healing and tissue engineering applications due to their excellent nontoxic, biocompatible, and biodegradable properties. Nanofibers with a diameter in the nanometer range possess a larger surface area per unit mass permitting easier addition of surface functionalities and release of biotherapeutics incorporated compared with conventional polymeric microfibers. Henceforth, nanofibers are a choice for fabricating scaffolds for the management of wound healing. Nanofibrous scaffolds have emerged as a promising method for fabricating wound dressings since they mimic the fibrous dermal extracellular matrix milieu that offers structural support for wound healing and functional signals for guiding tissue regeneration. Cellulose-based nanofibers have gained significant attention among researchers in the fabrication of on-site biodegradable scaffolds fortified with biotherapeutics in the management of wound healing. Cellulose is a linear, stereoregular insoluble polymer built from repeated units of d-glucopyranose linked with 1,4-β glycoside bonds with a complex and multilevel supramolecular architecture. Cellulose is a choice and has been used by various researchers due to its solubility in many solvents and its capacity for self-assembly into nanofibers, facilitating the mimicry of the natural extracellular matrix fibrous architecture and promoting substantial water retention. It is also abundant and demonstrates low immunogenicity in humans due to its nonanimal origins. To this end, cellulose-based nanofibers have been studied for protein delivery, antibacterial activity, and biosensor applications, among others. Taken together, this review delves into an update on cellulose-based nanofibers fused with bioactive compounds that have not been explored considerably in the past few years.

Ocular delivery is the most challenging aspect in the field of pharmaceutical research. The major hurdle for the controlled delivery of drugs to the eye includes the physiological static barriers such as the complex layers of the cornea, sclera and retina which restrict the drug from permeating into the anterior and posterior segments of the eye. Recent years have witnessed inventions in the field of conventional and nanocarrier drug delivery which have shown considerable enhancement in delivering small to large molecules across the eye. The dynamic challenges associated with conventional systems include limited drug contact time and inadequate ocular bioavailability resulting from solution drainage, tear turnover, and dilution or lacrimation. To this end, various bioactive-based nanosized carriers including liposomes, ethosomes, niosomes, dendrimer, nanogel, nanofibers, contact lenses, nanoprobes, selenium nanobells, nanosponge, polymeric micelles, silver nanoparticles, and gold nanoparticles among others have been developed to circumvent the limitations associated with the conventional dosage forms. These nanocarriers have been shown to achieve enhanced drug permeation or retention and prolong drug release in the ocular tissue due to their better tissue adherence. The surface charge and the size of nanocarriers (10-1000 nm) are the important key factors to overcome ocular barriers. Various nanocarriers have been shown to deliver active therapeutic molecules including timolol maleate, ampicillin, natamycin, voriconazole, cyclosporine A, dexamethasone, moxifloxacin, and fluconazole among others for the treatment of anterior and posterior eye diseases. Taken together, in a nutshell, this book chapter provides a comprehensive perspective on the numerous facets of ocular drug delivery with a special focus on bioactive nanocarrier-based approaches, including the difficulties and constraints involved in the fabrication of nanocarriers. This also provides the detailed invention and applications of nanocarriers for the ophthalmic delivery of therapeutics.

Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

Cucurbit[n]uril (CB[n], n = 5-10), a unique category of molecular hosts composed of n glycoluril units, has attracted considerable attention because of its exceptional molecular recognition properties. Cucurbit[n]urils represent an innovative category of molecular containers capable of forming stable complexes with a wide array of guests, including pharmaceutical compounds, amino acids, proteins or peptides, saccharides, and dyes, among others. Compared to the chemistry of calixarenes and cyclodextrins, the advancement of CB[n] chemistry has been rather sluggish until recently. This is mainly due to their inadequate solubility in typical solvents and the difficulties involved in functionalising these compounds. Cucurbiturils are characterised as water-soluble, symmetrical, rigid host molecules with a pumpkin-like form. The distinctiveness of cucurbiturils facilitates the encapsulation of diverse pharmacological molecules, both neutral and positively charged, via non-covalent interactions, yielding femtomolar affinities. This feature article summarises numerous studies conducted by researchers on the applicability of cucurbiturils and their derivatives in targeted medication delivery and controlled drug release. In vitro and in vivo experiments indicate that cucurbit[n]urils possess negligible systemic toxicity, exhibit specific organ toxicity, and do not seem to affect embryonic biology. Drug delivery methods that improve upon those of other supramolecular host molecules, especially cyclodextrins, and alternative formulation systems like polymers, hydrogels, and liposomes are anticipated to be developed as a result of the increasing fascination with cucurbituril-based systems, which are known for their low acute toxicity. The case studies show a wide range of usage, from basic research to translational uses in fields including gene therapies, antibiotics, and chemotherapy, among others.