Yannis Mantas Paulus

Dr. Yannis Mantas Paulus

Department of Ophthalmology and Visual Sciences, Department of Biomedical Engineering, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
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Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2008 in Archives of Ophthalmology (1950)
Verified
Journal Article
Open access
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AJAtul Jain
Atul Jain
MBMark S. Blumenkranz
Mark S. Blumenkranz
YPYannis Mantas Paulus
Yannis Mantas Paulus
MWMichael W. Wiltberger
Michael W. Wiltberger
DADan E. Andersen
Dan E. Andersen
DPDaniel Palanker
Daniel Palanker
The treatment parameters for retinal photocoagulation have remained relatively constant since the first description of an argon laser (514-nm wavelength) coupled to a slitlamp delivery system in 1970.1 The 3 separate but interdependent variables available to the clinician are the beam size, power, and duration of the pulse. Typically, for diabetic retinopathy, retinal vascular applications, and the treatment of retinal breaks, the retinal laser spot sizes range from 100 to 500 μm; the pulse durations, from 100 to 200 milliseconds; and the power, from 100 to 750 mW. The clinical appearance of the retinal lesions in these applications ranges from mild gray to a moderate white.2 For the thermal destruction of tumors and extrafoveal choroidal neovascular membranes, somewhat longer-duration lesions, ranging from 200 to 500 milliseconds, and longer wavelengths in the yellow-red spectrum are often used.3

4 January 2021 in Nature Communications
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Journal Article
Open access
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VNVan Phuc Nguyen
Van Phuc Nguyen
WQWei Qian
Wei Qian
YLYanxiu Li
Yanxiu Li
BLBing Liu
Bing Liu
MAMichael Aaberg
Michael Aaberg
YPYannis Mantas Paulus
Yannis Mantas Paulus
Colloidal gold nanoparticles (GNPs) serve as promising contrast agents in photoacoustic (PA) imaging, yet their utility is limited due to their absorption peak in the visible window overlapping with that of hemoglobin. To overcome such limitation, this report describes an ultrapure chain-like gold nanoparticle (CGNP) clusters with a redshift peak wavelength at 650 nm. The synthesized CGNP show an excellent biocompatibility and photostability. These nanoparticles are conjugated with arginine-glycine-aspartic acid (RGD) peptides (CGNP clusters-RGD) and validated in 12 living rabbits to perform multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) for visualization of newly developed blood vessels in the sub-retinal pigment epithelium (RPE) space of the retina, named choroidal neovascularization (CNV). The PAM system can achieve a 3D PAM image via a raster scan of 256 × 256 pixels within a time duration of 65 s. Intravenous injection of CGNP clusters-RGD bound to CNV and resulted in up to a 17-fold increase in PAM signal and 176% increase in OCT signal. Histology indicates that CGNP clusters could disassemble, which may facilitate its clearance from the body.

6 September 2021 in Current Diabetes Reports
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Journal Article
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LELesley A. Everett
Lesley A. Everett
YPYannis Mantas Paulus
Yannis Mantas Paulus

1 December 2008 in Investigative Ophthalmology & Visual Science
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Journal Article
Closed access
PDF file
YPYannis Mantas Paulus
Yannis Mantas Paulus
AJAtul Jain
Atul Jain
RGRay F. Gariano
Ray F. Gariano
BSBoris V. Stanzel
Boris V. Stanzel
MMMichael Marmor
Michael Marmor
DPDaniel Palanker
Daniel Palanker
Purpose. To systematically assess the changes in retinal morphology during the healing of retinal photocoagulation lesions of various clinical grades.

20 January 2010 in Optics Letters
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Journal Article
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AZAdam de la Zerda
Adam de la Zerda
YPYannis Mantas Paulus
Yannis Mantas Paulus
RTRobert Teed
Robert Teed
SBSunil Bodapati
Sunil Bodapati
YDYosh Dollberg
Yosh Dollberg
SGSanjiv Sam Gambhir
Sanjiv Sam Gambhir
We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig’s eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye’s anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.

5 December 2018 in Light: Science & Applications
Verified
Journal Article
Open access
PDF file
WZWei Zhang
Wei Zhang
YLYanxiu Li
Yanxiu Li
VNVan Phuc Nguyen
Van Phuc Nguyen
ZHZiyi Huang
Ziyi Huang
ZLZhipeng Liu
Zhipeng Liu
YPYannis Mantas Paulus
Yannis Mantas Paulus
Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). The results demonstrate that our multimodality imaging system can non-invasively visualize RNV in both albino and pigmented rabbits to determine retinal pathology using PAM and OCT and verify the leakage of neovascularization using FM and fluorescein dye. This work presents high-resolution visualization of angiogenesis in rabbits using a multimodality PAM, OCT, and FM system and may represent a major step toward the clinical translation of the technology.