CYP2C19 gene polymorphism combination with inflammatory cell ratios was significant in the prognosis of coronary heart disease. A cross-sectional analysis study, with 6 months follow-up on 142 patients with acute coronary syndrome. Patients were analyzed for CYP2C19 gene polymorphisms by real-time polymerase chain reaction (PCR) and complete blood count to determine inflammatory cell ratios and recorded cardiovascular events (CEs) after following up to 6 months. For 90-day CEs, CYP2C19 gene polymorphism (Hazard Ratio (HR): 1.965, 95 % Confidence Interval (CI): 1.012–3.814), the combination of a neutrophil and lymphocyte ratio (NLR) ≥ 2.982 (HR: 13.001, 95 % CI: 1.37–97.304) or a platelet to lymphocyte ratio (PLR) ≥ 162.42 (HR: 2.878, 95 % CI: 1.212–6.835) was independent predictors of CEs. For 180-day CEs, CYP2C19 gene polymorphism combination with NLR ≥3.02 (HR: 13.946, 95 % CI: 1.833–106.121) or PLR ≥160.38 (HR: 5.349, 95 % CI: 1.379–20.745) or monocyte to lymphocyte ratio (MLR) ≥ 0.3 (HR: 4.699, 95 % CI: 1.032–31.393) were independent predictors of CEs. NLR, PLR or MLR combined with CYP2C19 gene polymorphism were stronger independent predictors of cardiovascular events in patients with acute coronary syndromes compared to CYP2C19 gene polymorphism and inflammatory cell ratios separately. CYP2C19 polymorphism and high NLR was the strongest predictor of both CEs at 90 days and 180 days.

Background: Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined. Objective: This study is the first to examine the rs243865 (−1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD. Methods: A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024. Results: More than three-quarters of patients with RH had carotid-femoral pulse wave velocity (PWV) >10 m/s and microalbuminuria at a prevalence of 79% (62/78) and 76% (59/78), respectively, and more than half of patients with RH had left ventricular mass index, relative wall thickness, and carotid artery stenosis with a prevalence of 56% (45/78), 55% (43/78), and 53% (41/78), respectively. Of the 78 studied patients with RH, the presence of genotype CC was 77% (60/78), genotype CT accounted for 21% (16/78), and genotype TT for 3% (2/78). The presence of single nucleotide polymorphism rs243865 (−1306C>T) with allele T was 23% (18/78). The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with ejection fraction and carotid artery stenosis with odds ratios (ORs) 8.1 (95% CI 1.3‐51.4; P=.03) and 4.5 (95% CI 1.1‐20.1; P=.048), respectively. The allele T was found to be significantly associated with arterial stiffness including brachial-ankle PWV and carotid-femoral PWV with the correlation coefficient of OR 2.2 (95% CI 0.6‐3.8) and OR 1.8 (95% CI 0.5‐3.2), respectively. Conclusions: The MMP-2 gene polymorphism rs243865 (−1306C>T) may have an association with measurable TOD in RH.

BACKGROUND Resistant hypertension presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of Matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage. Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in resistant hypertension remains inadequately defined. OBJECTIVE This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and in patients with resistant hypertension (RH), underscoring its critical role as a genetic determinant of target organ damage (TOD). METHODS A cross-sectional study with both descriptive and analytical components, in 78 patients with resistant hypertension at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024. RESULTS More than three-quarters of RH patients had carotid-femoral PWV >10 m/s and microalbuminuria at prevalence of 79.5% and 75.6%, respectively. And more than half of RH patients had LVMI, relative wall thickness and carotid artery stenosis with the prevalence of 56.4%, 55.1% and 52.6%, respectively. Of 78 studied resistent hypertension patients, the presence of genotype CC was 76.9%, genotype CT accounted for 20.5% and 2.6% of genotype TT. The percentage of SNP rs243865(-1306C>T) carring allele T was 23.1%. The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with EF and carotid artery stenosis with OR (95%CI) of 8.1(1.3-51.4); p=0.026 and 4.5(1.1-20.1); p=0.048 respectively. The allele T was found to be significantly associated with arterial stiffness including Brachial-ankle PWV and Carotid-Femoral PWV with the correlation coefficient (95%CI) of 2.2 (0.6-3.8) and 1.8 (0.5-3.2) respectively. CONCLUSIONS The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable target organ damage in resistant hypertension.

Background: In addition to being a major cardiovascular risk factor contributing to the global burden of disease and mortality, resistant hypertension is one of the diseases that presents several challenges in the treatment process. Target organ damage resulting from hyperemia will occur if uncontrolled extended high blood pressure is maintained. Changes in the anatomy and physiology of significant arteries and organs are typical signs of injury. The goal is to pinpoint specific organ damage and associated variables in resistant hypertensive patients. Objectives: Determine the extent of target organ damage and associated variables in individuals suffering from resistant hypertension. Materials and methods: patients were diagnosed with resistant hypertension at the Department of Interventional Cardiology – Neurology, Can Tho University of Medicine and Pharmacy Hospital and Can Tho Central General Hospital. Results: The most common causes of target organ damage are left ventricular concentric hypertrophy (65.3%) and proteinuria (75%). A logistic regression model study revealed that systolic blood pressure and eGFR levels were independently linked with target organ damage. The area under the curve (AUC) for predicting target organ damage is 0.995, with a p-value of 0.004. Conclusion: Assessing organ damage and regulating systolic blood pressure are crucial for individuals with difficult-to-control hypertension. Đặt vấn đề: Tăng huyết áp khó kiểm soát là một trong những bệnh lí gây nhiều khó khăn trong việc điều trị đồng thời đây cũng là yếu tố nguy cơ tim mạch chính gây gánh nặng bệnh tật và tử vong trên toàn cầu. Tình trạng huyết áp cao kéo dài không được kiểm soát, sẽ dẫn đến tổn thương cơ quan đích do tăng huyết áp (THA). Tổn thương đặc trưng là sự thay đổi cấu trúc và chức năng của các động mạch quan trọng và những cơ quan chính trong cơ thể. Mục tiêu: Xác định một số tổn thương cơ quan đích và một số yếu tố liên quan ở bệnh nhân tăng huyết áp khó kiểm soát. Đối tượng và phương pháp nghiên cứu: Bệnh nhân được chẩn đoán tăng huyết áp khó kiểm soát tại Khoa Tim mạch can thiệp –Thần kinh Bệnh viện Trường Đại học Y Dược Cần Thơ và Bệnh viện Đa khoa Trung Ương Cần Thơ. Thiết kế nghiên cứu mô tả cắt ngang. Kết quả: Tổn thương cơ quan đích chiếm tỷ lệ cao nhất là phì đại đồng tâm thất trái (65,3%), tiểu đạm (75% ). Phân tích mô hình hồi quy Logistic cho thấy giá trị huyết áp tâm thu và eGFR có mối liên quan độc lập với tổn thương cơ quan đích. Giá trị mô hình đường cong ROC trong dự báo tổn thương cơ quan đích có diện tích dưới đường cong 0,995 với p = 0,004. Kết luận: đánh giá tổn thương cơ quan đích và kiểm soát giá trị huyết áp tâm thu có vai trò quan trọng ở bệnh nhân tăng huyết áp khó kiểm soát.