Oroantral fistula (OAF) is a persistent pathological communication between the oral cavity and the maxillary sinus, often arising as a complication of dental extractions, trauma, or surgical procedures involving the maxilla. Despite various treatment options, a standardized, algorithmic approach remains lacking. To develop and present a comprehensive, evidence-based clinical decision-making algorithm for the diagnosis and management of OAF based on defect size, chronicity, sinus involvement, and infection status. A narrative review and synthesis of the literature were conducted, evaluating diagnostic modalities, microbiological profiles, and both conservative and surgical treatment options from 1990 to 2025. The resulting data informed the development of a stepwise flowchart that integrates clinical parameters and radiographic findings to guide practitioners in selecting the most appropriate therapeutic approach. The algorithm begins with an initial assessment including patient history, clinical and radiographic evaluation. Small asymptomatic OAFs (< 2 mm) are managed conservatively with hygiene protocols and nasal precautions. Infected small fistulas warrant antibiotics. Medium-sized OAFs (5–10 mm) in favorable locations are treated with local flaps, whereas large or unfavorably located fistulas (> 10 mm) require advanced surgical techniques such as buccal fat pad grafts, distant flaps, and regenerative materials like platelet-rich fibrin. Sinus health and chronicity are considered pivotal in determining treatment timing and method. This algorithm provides a structured, patient-centered framework for the management of OAF. By incorporating anatomical, pathological, and microbiological factors, it enhances clinical decision-making, improves treatment outcomes, and supports interdisciplinary coordination.

Background: Alveolar bone reconstruction with recombinant protein has several advantages, including less surgical timing, and reduced infection. This systematic review aims to assess the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) as a treatment modality for children with cleft lip and palate compared to the conventional iliac crest bone grafting approach. Methods: For current systematic review and meta-analysis, five electronic databases, namely, MEDLINE/PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, Web of Science, and ScienceDirect, were searched. The primary outcome measured in this review was bone volume and height after alveolar bone reconstruction surgery. The Risk of Bias Tool 2 assessed the risk of bias for randomized control trials and the Risk of Bias tool for non-randomized trials of interventions for non-randomized studies. By evaluating pooled meta-analysis, the mean difference was calculated. GRADE uncertainty of evidence was performed to assess the certainty of the results. Results: Of 230 identified studies, 6 randomized and 2 non-randomized studies were included in the current review. The average bone volume was higher among the rhBMP-2 group at 61.11% ± 24.6% than the iliac crest group at 59.12% ± 18.59%. The calculated mean bone height was higher in the iliac crest group at 78.65% ± 14.38% than in the rhBMP-2 group at 67.5% ± 5.45%. The risk of bias reported in the studies was low to moderate. The result of the meta-analysis supported using rhBMP-2 in alveolar bone reconstruction; however, no significant association was found (mean difference: −1.24; confidence interval: −4.14 to 1.67). Conclusions: The calculated meta-analysis reported no significant difference, and the quality of evidence measured was also moderate. Hence, more clinical trials are required to support using rhBMP-2 as an alternative to traditional techniques for treating cleft lip and palate.

Multidisciplinary Approach to Mandibular Ameloblastoma: A Case Report on Surgical and Prosthetic Management - Article abstract #944651

Multiple fibrolipomas of the tongue are rare benign tumors with a prevalence of 0.2% among both adults and children. Moreover, this lesion affecting an infant has not been reported in the literature. This is the first reported case of multiple fibrolipomas of the tongue in an infant. This case report describes the genetic sequencing and treatment of a 1‐year‐old child suffering from multiple fibrolipomas. Irregular growths on the anterior and lateral border of the tongue were reported by the mother of the child at the time of birth. The patient was presented to the hospital at the age of 1, and surgical excision of the lesions was performed under general anesthesia. The surgery was uneventful. Genetic sequencing was performed via whole exome sequencing, and two variants of the C2CD3 gene have been identified that may be associated with this condition, although causation has not yet been confirmed. Although this is a rare entity of the oral cavity, there are various differential diagnoses. Therefore, maxillofacial surgeons should perform histological diagnosis to confirm the findings. This is the first study in literature to understand the genetic sequencing of multiple fibrolipomas in an infant. Hence, the finding of this report can be utilized in further studies registering such cases.