The Northeast of Brazil is a leading region for small ruminants. However, these herds are primarily located in the semi-arid region and face significant losses due to fetal and perinatal mortality, frequently linked to the consumption of teratogenic toxic plants during pregnancy. This study investigated the clinical and epidemiological aspects related to abortions and malformations in 80 small ruminant farms in the semi-arid region of Brazil. Necropsies were also performed on fetuses and neonates, along with histopathological, molecular, and serological analyses of the herds to differentiate other conditions. Malformations were identified on approximately 42 farms, with arthrogryposis being the most common abnormality. Toxic plants, including Mimosa tenuiflora and Cenostigma pyramidalis, were recorded on 95.23% of the properties with reported malformations. Additionally, necropsies confirmed the association between the occurrence of these plants and malformations, abortions, and mortality, excluding infectious causes. These results underscore the urgent need for prevention and control strategies to mitigate the impact of toxic plants on small ruminant production in the semi-arid region.