In this work, a thermal degradation mechanism of room temperature vulcanized (RTV) phenyl silicone rubber that was vulcanized by different crosslinking agents was discussed. Firstly, RTV phenyl silicone rubber samples were prepared by curing hydroxyl-terminated polymethyldiphenylsiloxane via three crosslinking agents, namely, tetraethoxysilane (TEOS), tetrapropoxysilane (TPOS), and polysilazane. Secondly, the ablation properties of RTV phenyl silicone rubber were studied by the muffle roaster test and FT-IR. Thirdly, thermal stability of the three samples was studied by thermogravimetric (TG) analysis. Finally, to explore the thermal degradation mechanism, the RTV phenyl silicone rubber vulcanized by different crosslinking agents were characterized by TG analysis-mass spectrum (TG-MS) and pyrolysis gas chromatogram-mass spectrum (pyGC-MS). Results showed that the thermal stability of RTV phenyl silicone rubber is related to the amount of residual Si–OH groups. The residual Si–OH groups initiated the polysiloxane chain degradation via an ‘unzipping’ mechanism.

Examples of successful therapies using macromolecular prodrugs to which the drug is linked via covalent bonds have been reported; however, there are safety concerns which render them disfavourable for clinical applications. Therefore, it is essential to reassess this class of drugs by designing compounds that combine covalent linking with reducible linkers. Herein, the hydrophobic drug paclitaxel was modified into a polymerizable monomer and subsequently copolymerized with pH-sensitive monomers and redox-sensitive disulfide-based cyclic monomers. The resulting diblock copolymer can self-assemble into vesicles incorporating the hydrophobic drug PTX into the vesicle walls. On decreasing the pH value, the size of the vesicular drug container varied with the change in the hydrophobicity–hydrophilicity balance. Treatment with reducing agents mediated the disassembly of the aggregates facilitating the release of the drug moiety. Furthermore, in vitro cell experiments showed that the nanoparticles exhibited cytotoxicity, indicating that they have potential as a drug delivery system for anti-cancer treatments.