Background: The clinical findings of Behçet’s disease (BD) differ according to the country and race investigated. The most important genetic factor known in the pathogenesis of BD is HLA-B51, and this positivity is high in countries on the “Silk Road” where BD is as frequent as it is in Turkey. Although the positivity of HLA B51 is proven to be high in Turkey, there are no studies in the area of the western Black sea demonstrating its relation to the demographic. We aimed to investigate the association of HLA-B51 positivity in Turkish patients diagnosed as having BD and the relationship between the demographic and clinical findings of the patients. Results: In this descriptive, cross-sectional study, a convenience sample of adults with BD was obtained from an outpatient clinic of a university hospital in Turkey between January 2018 and January 2022. Patients were diagnosed as having BD according to the criteria of the International BD Study Group, and the patients’ sociodemographic and clinical characteristics were recorded retrospectively. Demographic data and the frequency of clinical findings were compared between patients who were HLA-B51-positive and HLA-B51-negative. Sixty patients (55.6%) were HLA-B51-positive. Oral ulceration, genital ulceration, thrombophlebitis, and family history of BD were found to be higher in patients who were HLA-B51-positive. Erythema nodosum, papulopustular eruption, pathergy positivity, arthritis, and ocular involvement were less frequent in patients with HLA-B51 positivity. However, there were no statistically significant differences according to the frequency of clinical findings between the HLA-B51-positive and HLA-B51-negative groups. Conclusions: HLA B51 positivity is not diagnostic of BD; however, it may affect clinical phenotypes. Although oral and genital ulcerations, thrombophlebitis, and positive family history of BD were found to be common in patients with HLA-B51 positivity, this relationship could not reach statistical significance.

En tr Aim: The objective of this study is to identify the demographic and clinical characteristics of our patients who were followed up and treated with cerebral palsy diagnosis. Materials and Methods: The information of 577 patients was analyzed. Results: 41.9% of patients were female,58.1% were male, the mean age was 6.57years. Age of diagnosis was 31.4% in 0-6 months; 36.7% at 6-12 months; 21.9% at 1-2 years and 10.1% after two years of age. There was spastic unilateral type in 23.2%, spastic bilateral type in 72.4%, dyskinetic type in 1.2%, hypotonic type in 0.2% and mixed type in 2.9% of the cases. In terms of etiologic factors,5% prenatal,10.6% perinatal,6.8% postnatal factors were affected.64% of our patients had more than one risk factor, 13.7% had no risk factor. The duration of resumption to the rehabilitation center is 3.05 years. In 51% of the patients there was a concomitant problem, in 49% there was no accompanying problem. Antispastic therapy was used in 9,6% of patients, anticonvulsant therapy in 22,6%, both treatment in 3,1%, others medical treatment in 8,4%. In 56,3% of the patients was no medical treatment.33,1% of patients were using orthosis,23,3% were using assistive devices. According to CMFCS,18.5% of the patients were in stage 1,25.5% in stage 2,18.4% in stage 3, 22.7% in stage 4 and 14.9% in stage 5. Pes equinus was detected most frequently. Botulinum toxin injection was applied in 42,3%, selective dorsal rhizotomy in 0,7% and orthopedic surgery in 21% of our patients. Conclusion: Knowing the epidemiologic character of cerebral palsy, regular follow-up, treatment of the patients can provide the least dependence on the child, increase the adaptation to the gathering. Amaç: Çalışmamızın amacı serebral palsi (SP) polikliniğinde SP tanısı ile takip ve tedavisi yapılan hastalarımızın demografik ve klinik özelliklerini belirlemektir. Gereç ve Yöntem: Düzenli takibi olan 577 hastanın bilgileri geriye dönük incelendi. Hastaların yaşı, cinsiyeti, etiyolojik faktörleri, problemlerin fark edildiği yaş, SP tipi, kaba motor fonksiyon klasifikasyon sistemiyle (KMFKS) değerlendirmesi, eşlik eden ikincil problemleri, muayene bulguları, rehabilitasyon merkezinde düzenli tedavi hizmeti alımı, ortez ve yardımcı cihazları, medikal tedavileri, uygulanan konservatif ve cerrahi tedavi yaklaşımları kaydedildi. Bulgular: Hastalarımızın %41,9’u kız, %58,1’i erkek, yaş ortalaması 6,57 (±3,17) yıl idi. Tanı alma yaşı 0-6 ayda %31,4; 6-12 ayda %36,7; 1-2 yaşta %21,9 ve iki yaşından sonra %10,1 idi. Olguların %23,2’sinde spastik unilateral tip, %72,4’ünde spastik bilateral tip, %1,2’sinde diskinetik tip, %0,2’sinde hipotonik tip ve %2,9’unda mikst tip tutulum mevcuttu. Etiyolojik faktörler açısından %5 prenatal, %10,6 perinatal, %6,8 postnatal faktörler etkendi. Hastalarımızın %64’ünde birden çok risk faktörü mevcutken, %13,7’sinde risk faktörü saptanmamıştır. Rehabilitasyon merkezine devam süresi 3,05(±2,8) yıldı. Hastaların %51'inde eşlik eden problem mevcutken %49’unda eşlik eden problem yoktu. Hastalarımızın %9,6’sında antispastik tedavi, %22,6‘sında antikonvülzan tedavi, %3,1’inde antispastik ve antikonvülzan tedavi, %8,4’ünde bunların dışında medikal tedavi mevcutken, %56,3’ünde herhangi bir medikal tedavisi yoktu. Hastaların ilk başvuruda %33,1’i ortez, %23,3'ü yardımcı cihaz kullanmaktaydı. KMFKS’ye göre hastaların %18,5’i evre 1, %25,5’i evre 2, %18,4’ü evre 3, %22,7’si evre 4 ve %14,9’u evre 5 idi. En sık ekin yürüyüşü saptandı. Hastalarımızın %42,3’üne botulinum toksin enjeksiyonu, %0,7’sine selektif dorsal rizotomi, %21’ine ortopedik cerrahi uygulanmıştı. Sonuç: Serebral palsinin epidemiyolojik karakterinin bilinmesi, hastaların düzenli takibi ve tedavisi çocuğun bağımlılığını en aza indirip topluma uyumunun artmasını sağlayabilir .

Background: There are very few studies in the literature evaluating the effects of mask use on physiological parameters. Objectives: This study aims to examine physiological changes due to masks in healthcare workers who use respiratory masks for long hours in the emergency room during the pandemic process. Methods: Cross-sectional and prospective study was carried out with healthcare professionals with an FFP2 type valve mask. The participants’ transcutaneous oxygen saturation, pulse, and respiratory rate were measured before wearing the respirator mask and at 30 and 60 minutes after wearing the mask. Results: SPO2 values of the participants decreased gradually at 0th, 30th, and 60th minutes and respiratory rate increased gradually at 0th, 30th, and 60th minutes. The statistically significant difference arises from the 0 and 60 minutes values. Higher SPO2 values were found at 0 and 30 minutes in non-smokers. SPO2 value gradually decreased in non-smokers at 0, 30, and 60 minutes, but no significant decrease was observed in non-smokers. Pulse rate was found to be higher at 60th minute compared to 0th minute in non-smokers. No significant difference was found between smokers and non-smokers. The respiratory rate gradually increased in smokers at 0th, 30th, and 60th minutes. SPO2 values were lower at the 60th minute compared to the 0th minute in both women and men. There was no significant difference in pulse rates. Respiratory rate was found to be higher at 60th minute in men than at 0th minute. Conclusion: It is recommended to follow the physiological parameters and to regulate the working conditions when necessary.