This study focused on the synthesis of plant-mediated copper-oxide nanoparticles (OsCuONPs) via the sol–gel technique and the fabrication of OsCuONP-infused PVA composite films (POsCuONPs) utilizing the solvent casting method for wound-healing applications. The prepared OsCuONPs and nanocomposite films were characterized using UV–visible spectra, FTIR, SEM, XRD, TGA, water contact-angle (WCA) measurements, and a Universal testing machine (UTM) for mechanical property measurements. The UV and FTIR tests showed that OsCuONPs were formed and were present in the PVA composite film. Moreover, the mechanical study confirmed that there is an increase in the tensile strength (T_S) and Young’s modulus (Y_m) with 21.75 MPa to 32.50 MPa for T_S and 24.80 MPa to 1128.36 MPa for Y_m, and a decrease in the % elongation at break (E_b) (394.32 to 75.6). The TGA and WCA study results demonstrated that PVA films containing OsCuONPs are more stable when subjected to high temperatures and demonstrate a decreased hydrophilicity (60.89° to 89.62°). The cytotoxicity and hemolysis tests showed that the CuONPs-3 containing composite films (PVA/OsCuONPs with a wt. ratio of 1.94/0.06) are safe to use, have a good level of cell viability, and do not break down blood. This is true even at high concentrations. The study also discovered that cells moved considerably in 12 and 24 h (13.12 to 19.26 for OsCuONPs and 312.53 to 20.60 for POsCuONPs), suggesting that 60% of the gaps were filled. Therefore, the fabricated POsCuONP nanocomposites may serve as a promising option for applications in wound healing.

Over the past two decades, food packaging and packaging industry have paid close attention to create biodegradable and edible polymer films and coatings. In a broad way, edible polymers emerged as a new class of materials that garnered significant properties due to their advantages over synthetic petroleum-based films. When compared to conventional packaging materials, edible polymer films can fundamentally simplify products, improving their potential to be recycled. This work aims to give readers a thorough introduction to edible polymer films, by discussing present research trends, classification, functionality and composition, fabrication, and characterization. The work also emphasizes the advantages and disadvantages of edible polymer films based on meat, poultry, dairy products, fruits, nuts, and vegetables.

For the development of new anti-tubercular (TB) drugs, imidazopyridine-chalcone conjugates were synthesized. A combination of elemental and spectroscopy analysis was used for structural characterization of newly developed compounds. Anti-TB screening and cytotoxicity assays with Vero cells were conducted to evaluate the effectiveness of the synthesized compounds. It was found that few compounds were more effective than standard anti-TB drug pyrazinamide. Based on docking experiments performed on mycobacterium tuberculosis InhA bound to NITD-916 (PDB: 4R9S), certain compounds showed a greater affinity for protein binding. Moreover, the most active anti-TB compounds had outstanding safety profiles and exhibited high levels of interaction with the target protein. They may prove valuable as leads to new anti-TB treatments. The results clearly indicate that imidazopyridine-chalcone compounds may offer a good platform for developing effective antitubercular agents.