Adverse childhood experiences (ACEs; e.g., physical abuse) can impact lifelong mental health both directly and intergenerationally, with effects transmitted from the parent to the child. Several physiological mechanisms have been proposed to explain the impacts of ACEs on mental health. The purpose of this narrative review was to synthesize and critique the peer-reviewed literature on physiological mechanisms proposed to underlie the impacts of ACEs on mental health, specifically: (1) hypothalamic–pituitary–adrenal axis functioning, (2) inflammation, (3) genetic inheritance and differential susceptibility, (4) epigenetics, (5) brain structure and function, (6) oxidative stress, and (7) metabolic profiles. We searched Google Scholar using variations of the terms “adverse childhood experiences”, “mechanisms”, and “mental health” to locate relevant peer-reviewed literature. We also mined citations of the identified literature to find additional important sources. The role of inflammation in the etiology of mental health conditions among those exposed to ACEs appeared promising, followed by hypothalamic–pituitary–adrenal axis functioning, brain structure and function, genetics, epigenetics, metabolism, and lastly, oxidative stress. Replication studies that examine the associations among ACEs, genetic inheritance and differential susceptibility, epigenetics, oxidative stress, and metabolism are required to better define links with mental health.

Valid and reliable developmental screening and assessment tools allow professionals to identify disabilities/delays in children, enabling timely intervention to limit adverse lifelong impacts on health. However, differences in child development related to culture, genetics, and perinatal outcomes may impact tool applicability. This study evaluated the validity, reliability, and accessibility of multidomain developmental screening tools for young children, analyzed the applicability of tools across different contexts, and created a compendium of tools. Employing adapted realist review methods, we searched APA PsycInfo, MEDLINE, CINAHL, ERIC, and Google to identify relevant articles and information. We assessed accessibility, validity, reliability, and contextual applicability (N = 4110 evidence sources) to create tool ratings and make recommendations. Of 33 identified tools, 22 were screening and 11 were assessment tools. Fewer screening tools than assessment tools were rated highly overall. Evidence for use in different cultures was often lacking for both types of tools. The ASQ (screening) and BDI (assessment) tools were rated most favorably and are recommended for use, though other tools may be more applicable in different contexts (e.g., NEPSY among children with Asperger’s Syndrome). Future research should focus on assessing the validity and reliability of tools across different demographics to increase accessibility and ensure all children are properly supported.

COVID-19 infection and pandemic-related stressors (e.g., socioeconomic challenges, isolation) resulted in significant concerns for the health of mothers and their newborns during the perinatal period. Therefore, the primary objective of this study was to compare the health outcomes of pregnant mothers and their newborns one year prior to and one year into the pandemic period in Alberta, Canada. Secondary objectives included investigating: 1) predictors of admission to neonatal intensive care units (NICU) and to compare NICU-admitted newborn health outcomes between the two time periods; 2) hospital utilization between the two time periods; and 3) the health outcomes of mothers and their newborns following infection with COVID-19. This analytical cross-sectional study used a large administrative dataset (n = 32,107) obtained from provincial regional hospitals and homebirths in Alberta, Canada, from April 15, 2019, to April 14, 2021. Descriptive statistics characterized the samples. Chi-squares and two-sample t-tests statistically compared samples. Multivariable logistic regression identified predictor variables. General characteristics, pregnancy and labor complications, and infant outcomes were similar for the two time periods. Preterm birth and low birthweight predicted NICU admission. During the pandemic, prevalence of hospital visits and rehospitalization after discharge decreased for all infants and hospital visits after discharge decreased for NICU-admitted neonates. The odds of hospital revisits and rehospitalization after discharge were higher among newborns with COVID-19 at birth. Most of the findings are contextualized on pandemic-related stressors (rather than COVID-19 infection) and are briefly compared with other countries. Hospitals in Alberta appeared to adapt well to COVID-19 since health conditions were comparable between the two time periods and COVID-19 infection among mothers or newborns resulted in few observable impacts. Further investigation is required to determine causal reasons for changes in hospital utilization during the pandemic and greater birthweight among pandemic-born infants.

Insecure and disorganized attachment patterns in children are linked to poor health outcomes over the lifespan. Attachment patterns may be predicted by variables that influence the quality of children’s interactions with their primary caregivers/parents (usually mothers) such as prenatal and postnatal exposures and the children’s own behaviours in interactions. The purposes of this exploratory study were to examine: (1) prenatal predictors of children’s attachment patterns, and (2) postnatal mediators and moderators of associations between prenatal predictors and children’s attachment patterns, with adjustment for relevant covariates. Mother–child dyads (n = 214) from the longitudinal Alberta Pregnancy Outcomes and Nutrition (APrON) cohort were studied using valid and reliable measures. Hayes’ mediation analysis was employed to determine direct and indirect effects. Mothers’ prenatal cortisol levels directly predicted disorganized (versus organized) child attachment in unadjusted models. Children’s passivity (in adjusted models) and compulsivity (in unadjusted and adjusted models) in parent-child interactions mediated the pathway between mothers’ prenatal cortisol levels and children’s disorganized attachment patterns. Serial mediation analyses revealed that mothers’ cortisol levels predicted their children’s cortisol levels, which predicted children’s compulsivity, and, ultimately, disorganized attachment in both unadjusted and adjusted models. No predictors were correlated with children’s insecure (versus secure) attachment. This exploratory research suggests that prenatal exposure to mothers’ cortisol levels and children’s behavioural contributions to parent–child interaction quality should be considered in the genesis of children’s attachment patterns, especially disorganization. Interventions focused on parent-child interactions could also focus on addressing children’s behavioral contributions.

VID-KIDS (Video-Feedback Interaction Guidance for Depressed Mothers and their Infants) is a positive parenting programme comprising three brief nurse-guided video-feedback sessions (offered in-person or virtually via Zoom) that promote “serve and return” interactions by helping depressed mothers to be more sensitive and responsive to infant cues. We examined whether mothers who received the VID-KIDS programme demonstrated improved maternal–infant interaction quality. The secondary hypotheses examined VID-KIDS’ effects on maternal depression, anxiety, perceived parenting stress, infant developmental outcomes, and infant cortisol patterns. A parallel group randomized controlled trial (n = 140) compared the VID-KIDS programme to standard care controls (e.g., a resource and referral programme). The trial was registered in the US Clinical Trials Registry (number NCT03052374). Outcomes were assessed at baseline, nine weeks post-randomization (immediate post-test), and two months post-intervention. Maternal–infant interaction quality significantly improved for the intervention group with moderate to large effects. These improvements persisted during the post-test two months after the final video-feedback session. No significant group differences were detected for secondary outcomes. This study demonstrated that nurse-guided video-feedback can improve maternal–infant interaction in the context of PPD. These findings are promising, as sensitive and responsive parenting is crucial for promoting children’s healthy development.