Rachele Simonte

Dr. Rachele Simonte

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 December 2023 in Journal of Personalized Medicine
Verified
Journal Article
Open access
PDF file
GMGiovanni Misseri
Giovanni Misseri
Luciano FrassanitoLuciano Frassanito
Luciano Frassanito
RSRachele Simonte
Rachele Simonte
TRTommaso Rosà
Tommaso Rosà
DGDomenico Luca Grieco
Domenico Luca Grieco
Cesare GregorettiCesare Gregoretti
Cesare Gregoretti
Background: Noninvasive respiratory support (NRS), including high-flow nasal oxygen therapy (HFNOT), noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP), are routinely used in the perioperative period. Objectives: This narrative review provides an overview on the perioperative use of NRS. Preoperative, intraoperative, and postoperative respiratory support is discussed, along with potential future areas of research. Results: During induction of anesthesia, in selected patients at high risk of difficult intubation, NIV is associated with improved gas exchange and reduced risk of postoperative respiratory complications. HFNOT demonstrated an improvement in oxygenation. Evidence on the intraoperative use of NRS is limited. Compared with conventional oxygenation, HFNOT is associated with a reduced risk of hypoxemia during procedural sedation, and recent data indicate a possible role for HFNOT for intraoperative apneic oxygenation in specific surgical contexts. After extubation, “preemptive” NIV and HFNOT in unselected cohorts do not affect clinical outcome. Postoperative “curative” NIV in high-risk patients and among those exhibiting signs of respiratory failure can reduce reintubation rate, especially after abdominal surgery. Data on postoperative “curative” HFNOT are limited. Conclusions: There is increasing evidence on the perioperative use of NRS. Use of NRS should be tailored based on the patient’s specific characteristics and type of surgery, aimed at a personalized cost-effective approach.

26 April 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
RSRachele Simonte
Rachele Simonte
GCGianmaria Cammarota
Gianmaria Cammarota
Luigi VetrugnoLuigi Vetrugno
Luigi Vetrugno
EREdoardo De Robertis
Edoardo De Robertis
FLFederico Longhini
Federico Longhini
Savino SpadaroSavino Spadaro
Savino Spadaro
Advanced respiratory monitoring encompasses a diverse range of mini- or noninvasive tools used to evaluate various aspects of respiratory function in patients experiencing acute respiratory failure, including those requiring extracorporeal membrane oxygenation (ECMO) support. Among these techniques, key modalities include esophageal pressure measurement (including derived pressures), lung and respiratory muscle ultrasounds, electrical impedance tomography, the monitoring of diaphragm electrical activity, and assessment of flow index. These tools play a critical role in assessing essential parameters such as lung recruitment and overdistention, lung aeration and morphology, ventilation/perfusion distribution, inspiratory effort, respiratory drive, respiratory muscle contraction, and patient–ventilator synchrony. In contrast to conventional methods, advanced respiratory monitoring offers a deeper understanding of pathological changes in lung aeration caused by underlying diseases. Moreover, it allows for meticulous tracking of responses to therapeutic interventions, aiding in the development of personalized respiratory support strategies aimed at preserving lung function and respiratory muscle integrity. The integration of advanced respiratory monitoring represents a significant advancement in the clinical management of acute respiratory failure. It serves as a cornerstone in scenarios where treatment strategies rely on tailored approaches, empowering clinicians to make informed decisions about intervention selection and adjustment. By enabling real-time assessment and modification of respiratory support, advanced monitoring not only optimizes care for patients with acute respiratory distress syndrome but also contributes to improved outcomes and enhanced patient safety.

6 October 2024 in Medical Sciences
Verified
Journal Article
Open access
PDF file
GSgioele simonte
gioele simonte
GFGianluigi Fino
Gianluigi Fino
GPGianbattista Parlani
Gianbattista Parlani
RSRachele Simonte
Rachele Simonte
GIGiacomo Isernia
Giacomo Isernia
Purpose: This paper aims to describe a straightforward, efficient, and reliable technique to simplify cannulation maneuvers during aortic branched endograft repair. Technique: The suggested approach utilizes the Penumbra Neuron Select catheter, which combines diagnostic, sizing, and support capabilities in one. This has the potential to reduce procedural time and minimize the need for serial catheter and guidewire exchanges. Conclusions: The proposed technique offers a simple yet effective tool to mitigate the risk of vessel loss and injury, and to streamline complex aortic repair procedures.

2 August 2026
Verified
Book Chapter
Closed access
PDF file
EREdoardo De Robertis
Edoardo De Robertis
RSRachele Simonte
Rachele Simonte
EBEnrico Bertoli
Enrico Bertoli

1 August 2026 in British Journal of Anaesthesia
Verified
Journal Article
Open access
RSRachele Simonte
Rachele Simonte
MCMarta Caviglia
Marta Caviglia
FVFederico Verdina
Federico Verdina
CRChiara Robba
Chiara Robba
EREdoardo De Robertis
Edoardo De Robertis
GCGianmaria Cammarota
Gianmaria Cammarota

28 April 2026 in Nutrients
Verified
Journal Article
Open access
PDF file
MSMarialaura Scarcella
Marialaura Scarcella
ACAntonella Cotoia
Antonella Cotoia
Luigi VetrugnoLuigi Vetrugno
Luigi Vetrugno
Emidio ScarpelliniEmidio Scarpellini
Emidio Scarpellini
GPGian Marco Petroni
Gian Marco Petroni
EBElena Giovanna Bignami
Elena Giovanna Bignami
Background: Critical illness is characterized by profound and rapidly evolving metabolic derangements driven by systemic inflammation, hypercatabolism, fluid shifts, and endocrine dysregulation. These dynamic changes markedly limit the accuracy of predictive equations, increasing the risk of both underfeeding and overfeeding. Indirect Calorimetry Energy represents the gold standard for measuring energy expenditure, while bioelectrical impedance vector analysis (BIVA) provides complementary insights into hydration status, cellular integrity, and body cell mass. In palliative care, AI-supported integration of indirect calorimetry and BIVA enables goal-concordant artificial nutrition by aligning energy delivery with real-time metabolic status while minimizing symptom burden. Artificial intelligence (AI) has emerged as a promising tool to integrate these heterogeneous data streams and support adaptive nutritional strategies. Methods: We conducted a structured narrative review of the literature published between 2000 and 2025 using PubMed, Scopus, Embase, and Web of Science. Artificial intelligence was not used to perform the literature search or study selection. Instead, AI was analyzed as a clinical and technological component within the included studies and explored as a future enabling strategy. Eligible publications involved adult critically ill patients and addressed indirect calorimetry, BIVA-derived parameters, or AI-based metabolic modeling applied to nutritional support. Given the heterogeneity of study designs and outcomes, findings were synthesized qualitatively. Results: Predictive equations showed substantial inaccuracy in unstable metabolic states, with errors frequently exceeding ±20–40%. Indirect calorimetry enabled individualized assessment of energy expenditure but remained limited by intermittent availability. Serial BIVA assessments consistently identified clinically relevant alterations in hydration status, body cell mass, and phase angle, the latter being strongly associated with adverse outcomes. Studies incorporating AI demonstrated improved integration of calorimetry, BIVA, and clinical variables, allowing identification of metabolic phenotypes, anticipation of metabolic shifts, and generation of adaptive nutritional recommendations. Conclusions: This narrative review highlights the complementary roles of Indirect Calorimetry and BIVA in characterizing metabolic needs in critical illness. Artificial intelligence does not replace these tools but enhances their clinical utility by integrating multidimensional data into dynamic, patient-specific nutritional strategies. The combined AI–IC–BIVA approach represents a promising framework for metabolic precision nutrition in the ICU, warranting prospective validation.