Introduction: In the face of evolving public health challenges, including emerging diseases, pervasive health disparities, and escalating environmental threats, the integration of learning health system (LHS) principles emerges as a vital strategy for enhancing the adaptability and efficacy of public health initiatives. Traditional approaches within these systems often overlook the potential to deeply involve community‐based organizations (CBO) that are led and staffed by the communities they serve as equal and essential partners in the public health discourse.Methods: This commentary proposes a suite of nine community‐led transformation (CLT) principles aimed at reimagining LHS frameworks to authentically incorporate CBOs at their core. Drawing on the experiences from initiatives supporting Afghan refugees, we illustrate the application of these principles through two detailed case studies.Results: These examples demonstrate the CLT principles in action and spotlight the enhanced cultural competency, effectiveness, and equitable power distribution that arise from such partnerships. Centering small to mid‐sized CBOs including ethnic‐led and/or faith based within LHS structures enables the system to access invaluable cultural insights, strengthen community bonds, and empower those communities to spearhead their transformative journey toward sustainable health, equity, and well‐being improvements.Conclusion: The CLT principles herald a shift toward a more inclusive and co‐led public health paradigm by offering a blueprint for stakeholders eager to forge strong, trust‐based coalitions and cocreate initiatives with community leaders including Black, Indigenous, and People of Color (BIPOC) leaders from ethnic‐led and/or faith‐based CBOs. By embracing these principles, public health systems can evolve into truly inclusive, responsive, and sustainable entities poised to advance health equity for all community members.

Refugee and immigrant communities face a host of dynamic health challenges. This essay discusses the importance of prioritizing the impacts of resettlement on mental health and provides examples of how creating a collective network of culturally responsive, trauma-informed, and healing-centered providers—centered on community-based best practices and knowledge—is integral to fostering community resilience. Additionally, it will examine how resettlement challenges intersect with systemic barriers to culturally responsive care and related Social Determinants of Health (SDOH), including economic stability, health care access and quality, and social and community contexts. Drawing upon experiences from a statewide network spanning southern and northern California—and based on interim mixed-methods program evaluation data and practitioner reflections highlighting one community partner’s experience—we provide key learnings that demonstrate how coalition building, cultural humility, and provider training can improve client well-being, reduce mental health disparities, and address the relevant SDOH. Key learnings illustrate the importance of the following: (1) coalition building to co-create trusted provider referral networks and support peer-to-peer learning to enhance client care; (2) provider trainings and capacity building on healing-centered and culturally responsive practices to address SDOH; (3) centering cultural humility; and (4) building a peer-based workforce who speak similar languages and share lived experiences to provide deeper cultural connections and build trust. Our experiences demonstrate that the co-creation of strong mental health provider networks is critical to strengthening the fabric of community resilience.

Community-academic partnerships are increasingly recognized as essential for advancing equitable public health outcomes. Yet many partnerships struggle to move beyond short-term, project-based collaboration toward sustained, trust-based engagement with communities. This commentary draws on the experience of the University of California San Diego Center for Community Health (CCH) and its long-standing partnerships with immigrant, refugee, and other underserved communities in San Diego County. Over more than two decades of practice, CCH and its community partners developed the Community-Led Transformation (CLT) approach to guide authentic community-academic collaboration. We describe three interdependent pillars of CLT: valuing community expertise, fostering trust-based partnerships, and ensuring fair access to resources and power-sharing. Examples from CCH programs, coalitions, and research collaborations illustrate how these principles are operationalized in practice. We also reflect on structural challenges within academic institutions, including funding instability, administrative barriers, and limitations in partnership infrastructure, and strategies used to navigate these constraints while sustaining community partnerships. We provide specific recommendations for academic partners, community partners, and funders to facilitate community-academic partnerships via increased capacity building, infrastructural supports, and greater relationship and trust building. The CLT framework has therefore been a success within CCH, and can provide practical insights for a variety of partners and institutions seeking to build authentic, durable partnerships that meaningfully advance public health and health equity.