Objectives: Integrins, the coordinator of extracellular and intracellular signaling, are often found to be aberrant in tumors and can reshape the tumor microenvironment. Although previous studies showed that integrin beta 2 (ITGB2) is important for host defense, its expression profile and role in tumors, especially in cancer associated fibroblasts (CAFs) are still unknown.

Significance: We show that the combination of conductive polymer spray mass spectrometry (CPSI-MS) and machine learning provides a simple, fast, and affordable method for oral squamous cell carcinoma diagnosis with 86.7% accuracy. By using CPSI-MS, the direct, high-throughput metabolic profiling of saliva can be readily realized in a noninvasive manner. The self-conductive materials used in CPSI-MS for sample loading and ionization are clean, cheap, and consumable for cohort analysis. Wide coverage of chemical species provides not only the pools of possible metabolite signatures for molecular diagnosis but also the possibility of exploring metabolite function and oncological mechanism. The analysis of saliva samples from 373 individuals was completed within 4.5 h, satisfying the technical demand for point-of-care testing.

Current surgical treatment for oral squamous cell carcinoma (OSCC) must be as precise as possible to fully resect tumors and preserve functional tissues. Thus, it is urgent to develop efficient fluorescent probes to clearly identify tumor delineation, as well as metastatic lymph nodes. Chemo-photothermal therapy combination attracted a growing attention to increase anti-tumor effect in various types of cancer, including OSCC. In the present study, we designed a multimodal NIR-II probe that involves combining photothermal therapy with chemotherapy, imaging OSCC tumors and detecting metastatic lymph nodes.

A multimodal drug delivery system targeting the tumor microenvironment is an inspiring method for treating cancer tissues, including oral squamous cell carcinomas (OSCC).

Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment Crosstalk between the HIF-1 and toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment