Introduction: Nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in intensive care units (ICUs) are increasing worldwide. Morbidity and mortality rates are quite high in these infections due to limited treatment options and various risk factors. We determined the rate of carbapenem resistance, risk factors for carbapenem resistance, mortality rate, and risk factors associated with mortality in nosocomial infections in the adult ICU. Methodology: We reviewed the medical records of nosocomial infected patients retrospectively, according to the surveillance diagnostic criteria established by the Centers for Diseases Control and Prevention. Bacterial identification and antibiotic susceptibility tests were performed on the Phoenix 100 system (Becton Dickinson, Sparks, MD, USA). During carbapenemase gene analysis, blaKPC, blaOXA-48, blaNDM-1, and blaIMP genes were investigated by polymerase chain reaction (PCR). Potential risk factors were statistically analyzed. Results: Carbapenem resistance was detected in 52/76 of these patients (68.4%). The OXA-48 gene was present in all isolates, and the combination of OXA-48 and NDM-1 was found in 40.4% isolates. The overall mortality rate was 59.2% (45/76). Presence of malignancy; intubation; antibiotic use in the last 3 months; and quinolone, glycopeptide, carbapenem, and antifungal use were determined as risk factors for the development of carbapenem-resistant K. pneumoniae. Mechanical ventilation, presence of carbapenemase and pan-resistant status, and glycopeptide use were independent risk factors for mortality. Conclusions: The data obtained in this study will guide the control measures for this infection and the rational use of antibiotics, and will contribute to the decrease in mortality rates.

This study aimed to determine the prevalence, distribution, and antimicrobial susceptibility patterns of multidrug-resistant (MDR) bacterial isolates in ad

Background: Mycetoma is a public health problem with a high prevalence in Africa. Materials and Methods: The study included 50 cases presenting at a tertiary care research hospital, retrospectively (cases we visited and followed up between November 2022 and March 2023) and prospectively between 1 August and 30 September 2024. Demographic characteristics, clinical features, physical examination findings, and diagnostic methods were reported. Results: Out of 50 patients, 76% were male and 24% were female. The mean age (mean ± SD) of all cases was 35.50 ± 15.14. The most affected occupational group was farmers (44%). All patients presented with complaints of swelling. Symptoms continued for > 1–5 years in about 30 percent of cases. The diagnosis was made by pathological biopsy in 62% of the cases. The lower extremities were most commonly affected (80%), and subcutaneous soft tissue and muscle involvement was also commonly encountered. Bone involvement was higher in eumycetoma cases as compared to actinomycetoma. Conclusion: The frequency of myçetoma cases, which can involve all parts of the lower extremities, was determined, especially in Somali farmers. Difficulties in diagnosis and follow‐up were analyzed.

Catheter-related bloodstream infections (CRBSIs) are among the most common healthcare-associated infections in neonates and contribute substantially to mor

Aims: Although HIV/AIDS was first identified in 1981, negative prejudices toward individuals living with this disease remain widespread. These stigmas create significant barriers, causing patients to conceal their condition, which in turn disrupts efforts for effective disease control, management, and treatment. Methods: A cross-sectional study was conducted with 301 participants, including physicians, nurses, midwives, health technicians, and laboratory staff working in our hospital, using an anonymous survey method. The study consisted of three sections and a total of 57 questions, focusing on participants' demographic information, knowledge about HIV, and attitudes towards HIV/AIDS patients. The survey was conducted by specialist physicians and general practitioners working in the infectious diseases clinic, as well as by Infection Control Committee nurses. During this process, both outpatient clinics and inpatient wards were visited, and the survey was completed through face-to-face interviews. The survey was carried out over a period of approximately two months. Results: The knowledge level of healthcare workers (HCWs) who participated in the survey was significantly higher than their positive biases (p