The regularity of rainfall seasonality is very important for vegetation growth, the livelihood of the population, agricultural production, and ecosystem sustainability. Changes in precipitation and its extremes have been widely reported; however, the spatial and temporal variations in rainfall seasonality and their underlying mechanisms are less understood. Here, we analyzed the changes in rainfall seasonality and possible teleconnection mechanisms in the eastern China monsoon region during 1981–2022, with a special focus on the El Niño-Southern Oscillation (ENSO), El Niño Modoki (ENSO_M), and Indian Ocean Dipole (IOD). Our results show that due to the changes in rainfall concentration, rainfall magnitude, or both, rainfall seasonality has developed in the northern China (NC, 0.15 × 10⁻³ yr⁻¹) and central China (CC, 0.07 × 10⁻³ yr⁻¹) monsoon regions, and weakened in the northeastern China (NEC, −0.08 × 10⁻³ yr⁻¹) and southern China (SC, −0.15 × 10⁻³ yr⁻¹) monsoon regions during the recent decades. The large-scale circulation and SST anomalies induced by cold or warm phases of the IOD, ENSO_M, and (or) ENSO can explain the enhanced seasonality in the NC and CC monsoon regions and weakened seasonality in the NEC and SC monsoon regions. The wavelet coherence analysis further shows that the dominated climatic factors for rainfall seasonality changes are different in the CC, NC, SC, and NEC monsoon regions, and that rainfall seasonality is also affected by the coupling of the IOD, ENSO_M, and ENSO. Our results highlight that the IOD, ENSO_M, and ENSO are important climatic causes for rainfall seasonality changes in the eastern China monsoon region.