Prof. chiara Schiraldi
University of Campania "Luigi Vanvitelli" Department of Experimental Medicine
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Academic Career Length
28Years (1999-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 October 2002 in Trends in Biotechnology
Journal Article
1 December 2002 in Trends in Biotechnology
Journal Article
chiara SchiraldiMRMario De Rosa
Mario De Rosa3 June 2010 in Applied Microbiology and Biotechnology
Journal Article
11 July 2015 in BMC Cell Biology
Journal Article
ADAntonella D’aGostino
Antonella D’aGostinoASAntonietta Stellavato
Antonietta StellavatoTBTeresa Busico
Teresa BusicoAPAgata Papa
Agata PapaVTVirginia Tirino
Virginia Tirinochiara Schiraldi +3
Recent studies have reported the roles of Hyaluronic acid (HA) chains of diverse length in wound repair, especially considering the simultaneous occurrence in vivo of both high- (H-HA) and low-molecular weight (L-HA) hyaluronan at an injury site. It has been shown that HA fragments (5 ≤ MW ≤ 20 kDa) usually trigger an inflammatory response that, on one hand, is the first signal in the activation of a repair mechanism but on the other, when it’s overexpressed, it may promote unwanted side effects. The present experimental research has aimed to investigate H-HA, L-HA and of a newly developed complex of the two (H-HA/L-HA) for stability (e.g. hyaluronidases digestion), for their ability to promote wound healing of human keratinocytes in vitro and for their effect on cellular biomarker expression trends.
1 February 2017 in Carbohydrate Polymers
Journal Article
ADAntonella D’aGostino
Antonella D’aGostinoASAntonietta Stellavato
Antonietta StellavatoLCLuisana Corsuto
Luisana CorsutoPDPaola Diana
Paola DianaRFRosanna Filosa
Rosanna Filosachiara Schiraldi +2
1 November 2016 in Carbohydrate Polymers
Journal Article
RSRosanna Salzillo
Rosanna Salzillo
chiara SchiraldiLCLuisana Corsuto
Luisana Corsuto
ADAntonella D’aGostino
Antonella D’aGostino
RFRosanna Filosa
Rosanna Filosa
AGAnnalisa La Gatta
Annalisa La Gatta +1
Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties. Hydrodynamic and rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 to about 1200kDa and viscosity values in the range 3.7-24.2mPa s. The latter suggest that most products could be optimized towards resistance to drainage from the ocular surface. Then, a study aiming to maximize the viscosity and mucoadhesiveness of HA-based preparations is performed. The effect of polymer chain length and concentration is investigated. For the whole range of molecular weights encountered in commercial products, the concentration maximizing performance is identified. Such concentration varies from 0.3 (wt%) for a 1100kDa HA up to 1.0 (wt%) for a 250kDa HA, which is 3-fold higher than the highest concentration on the market. The viscosity and mucoadhesion profiles of optimized formulations are superior than commercial products, especially under conditions simulating in vivo blinking. Thus longer retention on the corneal epithelium can be predicted. An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy.
About Me
Chiara Schiraldi is a Full Professor in Biochemistry, Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, School of Medicine, University of Campania “Luigi Vanvitelli” in Naples, Italy.
Coordinator of the Biotechnology Group of the Italian Society of Biochemistry (SIB) (since 2021).
Elected to the Board of the Assembly of the Italian Full Professors of Biochemistry (since 2021).
Board Member of the Life Science, Biotechnology and Biomedicine Regional District Campania Bioscience (since 2019).
Scientific and technical board member of Bioteknet, Regional Competence Center in Industrial Biotechnology (2010-2018).
Responsible for “Great Equipment Lab”-CGA, ISO9001 certified (since 2011).
Academic background:
Master's degree in Chemical Engineering summa cum laude University “Federico II” of Naples, Engineering Faculty (December,1996).
PhD in Biotechnology in Food and Health Second University of Naples and European Doctorate in Biotecnology HEduBT—higher education in Biotechnology, 2002.
Research interest in biotechnology; biopolymers, specifically glycosaminoglycans, from biosynthesis to the biomaterial and medical device development; and the use of in vitro models to assess the bioactivity of macromolecules for pharmaceutical and nutraceutical purposes.
More than 140 papers, more than 4400 citations, and an H index of 37 (as of September 2023).