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Laura Saderi
Department of Medical, Surgical and Experimental Sciences, University of Sassari, Via P. Manzella, 4, 07100 Sassari, Italy

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Journal article
Published: 14 August 2021 in International Journal of Molecular Sciences
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EGFR is overexpressed in the majority of clear cell renal cell carcinomas (CCRCCs). Although EGFR deregulation was found to be of great significance in CCRCC biology, the EGFR overexpression is not associated with EGFR-targeted therapy responsiveness. Moreover, the prognostic role of EGFR expression remains controversial. In the present study, we evaluated the role played by EGFR overexpression in CCRCC and its prognostic significance associated with different immunohistochemical localization patterns. In our study, the Total Score (TS) related to membranous-cytoplasmic EGFR expression showed a significant correlation with grade, pathologic stage (pT), and Stage, Size, Grade, and Necrosis (SSIGN) score, and a negative correlation with nuclear EGFR expression. No significant correlations were shown between nuclear EGFR and clinic-pathological features. Additionally, a correlation between SGLT1 expression levels and pT was described. Multivariate analysis identifies pT and SSIGN score as independent prognostic factors for CCRCC. A significantly increased survival rate was found in the case of positive expression of nuclear EGFR and SGLT1. Based on our findings, SGLT1 and nuclear EGFR overexpression defines a subgroup of CCRCC patients with good prognosis. Membranous-cytoplasmic EGFR expression was shown to be a poor prognostic factor and could define a CCRCC subgroup with poor prognosis that should be responsive to anti-EGFR therapies.

ACS Style

Maria Rosaria Muroni; Silvia Ribback; Giovanni Sotgiu; Nils Kroeger; Laura Saderi; Andrea Angius; Paolo Cossu-Rocca; Maria Rosaria De Miglio. Prognostic Impact of Membranous/Nuclear Epidermal Growth Factor Receptor Localization in Clear Cell Renal Cell Carcinoma. International Journal of Molecular Sciences 2021, 22, 8747 .

AMA Style

Maria Rosaria Muroni, Silvia Ribback, Giovanni Sotgiu, Nils Kroeger, Laura Saderi, Andrea Angius, Paolo Cossu-Rocca, Maria Rosaria De Miglio. Prognostic Impact of Membranous/Nuclear Epidermal Growth Factor Receptor Localization in Clear Cell Renal Cell Carcinoma. International Journal of Molecular Sciences. 2021; 22 (16):8747.

Chicago/Turabian Style

Maria Rosaria Muroni; Silvia Ribback; Giovanni Sotgiu; Nils Kroeger; Laura Saderi; Andrea Angius; Paolo Cossu-Rocca; Maria Rosaria De Miglio. 2021. "Prognostic Impact of Membranous/Nuclear Epidermal Growth Factor Receptor Localization in Clear Cell Renal Cell Carcinoma." International Journal of Molecular Sciences 22, no. 16: 8747.

Journal article
Published: 19 May 2021 in Journal of Clinical Medicine
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A multicenter, nonrandomized, prospective, controlled study was conducted to evaluate, as perioperative prophylactic treatment, the anti-infective effectiveness of 0.66% povidone-iodine eye drops (IODIM®) against the bacterial flora of the conjunctival surface of patients who undergo cataract surgery. Eye drops containing 0.66% povidone-iodine were applied to the eye undergoing cataract surgery; the untreated contralateral eye was used as control. One hundred and twenty patients set to receive unilateral cataract surgery were enrolled in 5 Italian Ophthalmology Centers and pretreated for three days with 0.66% povidone-iodine eye drops. The contralateral eye, used as control, was left untreated. Conjunctival swabs of both eyes were collected at the baseline visit and after three days of treatment, just before the cataract surgery. A qualitative and quantitative microbiological analysis of bacterial presence was evaluated by means of bacterial culture, followed by identification. Methicillin resistance determination was also performed on staphylococci isolates. Bacterial load before and after treatment of the eye candidate for cataract surgery was evaluated and compared to the untreated eye. A reduction or no regrowth on the culture media of the bacterial load was observed in 100% of the study subjects. A great heterogenicity of bacterial species was found. The 0.66% povidone-iodine eye drops, used for three days prior to cataract surgery, were effective in reducing the conjunctival bacterial load. The 0.66% povidone-iodine eye drops (IODIM®) might represent a valid perioperative prophylactic antiseptic adjuvant treatment to protect the ocular surface from microbial contamination in preparation of the surgical procedure.

ACS Style

Rosario Musumeci; Pasquale Troiano; Marianna Martinelli; Matteo Piovella; Claudio Carbonara; Scipione Rossi; Giovanni Alessio; Luisa Molteni; Claudio Molteni; Laura Saderi; Giovanni Sotgiu; Clementina Cocuzza. Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study. Journal of Clinical Medicine 2021, 10, 2198 .

AMA Style

Rosario Musumeci, Pasquale Troiano, Marianna Martinelli, Matteo Piovella, Claudio Carbonara, Scipione Rossi, Giovanni Alessio, Luisa Molteni, Claudio Molteni, Laura Saderi, Giovanni Sotgiu, Clementina Cocuzza. Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study. Journal of Clinical Medicine. 2021; 10 (10):2198.

Chicago/Turabian Style

Rosario Musumeci; Pasquale Troiano; Marianna Martinelli; Matteo Piovella; Claudio Carbonara; Scipione Rossi; Giovanni Alessio; Luisa Molteni; Claudio Molteni; Laura Saderi; Giovanni Sotgiu; Clementina Cocuzza. 2021. "Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study." Journal of Clinical Medicine 10, no. 10: 2198.

Journal article
Published: 01 April 2021 in Future Microbiology
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Background: Tuberculosis (TB) unevenly affects individuals across the globe, especially in rural areas of low-income countries. Aim of the study was to assess the impact of social protection to increase TB awareness on treatment outcomes among TB patients in a rural area of Senegal. Materials & methods: The study, conducted in Fimela district (Senegal) from 1 January 2010 to 31 December 2019 and the intervention started from 31 January 2013, includes activities to increase awareness, active case finding, active follow-up and social protection. Results: Overall, 435 subjects – mainly male and young – were included in the analysis. Among TB cases, 94% had pulmonary involvement, 87% had no previous TB history, and 6% resulted positive HIV. Improved outcome was observed once intervention began (from 71 to 91%, p < 0.001); whereas mortality decreased (from 15 to 5%; p < 0.001), especially for those HIV co-infected for whom TB mortality rate dropped from 70 to 29%. Conclusion: After beginning the cooperation program, TB treatment success increased as a result of the decline of mortality, especially in people living with HIV.

ACS Style

Niccolò Riccardi; Simone Villa; Andrea Giacomelli; Mama M Diaw; Mamoud Ndiaye; Lamine Gning; Marta Robbiano; Riccardo Alagna; Laura Saderi; Antonio Di Biagio; Matteo Bassetti; Daniela M Cirillo; Giovanni Sotgiu; Luigi R Codecasa; Marie Sarr; Giorgio Besozzi. Tuberculosis treatment outcomes in a rural area of Senegal: a decade of experience from 2010 to 2019 by StopTB Italia. Future Microbiology 2021, 16, 399 -407.

AMA Style

Niccolò Riccardi, Simone Villa, Andrea Giacomelli, Mama M Diaw, Mamoud Ndiaye, Lamine Gning, Marta Robbiano, Riccardo Alagna, Laura Saderi, Antonio Di Biagio, Matteo Bassetti, Daniela M Cirillo, Giovanni Sotgiu, Luigi R Codecasa, Marie Sarr, Giorgio Besozzi. Tuberculosis treatment outcomes in a rural area of Senegal: a decade of experience from 2010 to 2019 by StopTB Italia. Future Microbiology. 2021; 16 (6):399-407.

Chicago/Turabian Style

Niccolò Riccardi; Simone Villa; Andrea Giacomelli; Mama M Diaw; Mamoud Ndiaye; Lamine Gning; Marta Robbiano; Riccardo Alagna; Laura Saderi; Antonio Di Biagio; Matteo Bassetti; Daniela M Cirillo; Giovanni Sotgiu; Luigi R Codecasa; Marie Sarr; Giorgio Besozzi. 2021. "Tuberculosis treatment outcomes in a rural area of Senegal: a decade of experience from 2010 to 2019 by StopTB Italia." Future Microbiology 16, no. 6: 399-407.

Journal article
Published: 28 March 2021 in Animals
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Myxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs. It varies from dogs without clinical signs to those developing left-sided congestive heart failure, leading to death. Cavalier King Charles Spaniels (CKCSs) are particularly susceptible to MMVD. We hypothesised that within the elderly CKCS population, there is a sub-cohort of MMVD-affected dogs that do not have cardiac remodelling. The objectives of the present study were (i) to determine the prevalence and the degree of cardiac remodelling associated with MMVD; and (ii) assess the effect of age, gender, and body weight on echocardiographic status in a population of aged CKCSs. A total of 126 CKCSs ≥ 8 years old were prospectively included. They all had a physical and echocardiographic examination. A systolic murmur was detected in 89% of dogs; the presence of clinical signs was reported in 19% of them; and echocardiographic evidence of MMVD was described in 100%. Despite the high prevalence, 44.4% of the dogs were clear of echocardiographic signs of cardiac remodelling. Age was significantly associated with the presence and severity of cardiac remodelling and mitral valve prolapse. Our results showed that a proportion of elderly CKCS with confirmed MMVD did not undergo advanced stages of this pathology.

ACS Style

Jorge Prieto Ramos; Andrea Corda; Simon Swift; Laura Saderi; Gabriel De La Fuente Oliver; Brendan Corcoran; Kim Summers; Anne French. Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels. Animals 2021, 11, 949 .

AMA Style

Jorge Prieto Ramos, Andrea Corda, Simon Swift, Laura Saderi, Gabriel De La Fuente Oliver, Brendan Corcoran, Kim Summers, Anne French. Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels. Animals. 2021; 11 (4):949.

Chicago/Turabian Style

Jorge Prieto Ramos; Andrea Corda; Simon Swift; Laura Saderi; Gabriel De La Fuente Oliver; Brendan Corcoran; Kim Summers; Anne French. 2021. "Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels." Animals 11, no. 4: 949.

Journal article
Published: 09 March 2021 in Metabolites
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Prematurity is the leading cause of neonatal deaths and high economic costs; it depends on numerous biological and social factors, and is highly prevalent in males. Several factors can affect the metabolome of premature infants. Accordingly, the aim of the present study was to analyze the role played by gestational age (GA), parenteral nutrition (PN), and caffeine treatment in sex-related differences of blood metabolome of premature neonates through a MS/MS-based targeted metabolomic approach for the detection of amino acids and acylcarnitines in dried blood spots. GA affected the blood metabolome of premature neonates: male and female very premature infants (VPI) diverged in amino acids but not in acylcarnitines, whereas the opposite was observed in moderate or late preterm infants (MLPI). Moreover, an important reduction of metabolites was observed in female VPI fed with PN, suggesting that PN might not satisfy an infant’s nutritional needs. Caffeine showed the highest significant impact on metabolite levels of male MLPI. This study proves the presence of a sex-dependent metabolome in premature infants, which is affected by GA and pharmacological treatment (e.g., caffeine). Furthermore, it describes an integrated relationship among several features of physiology and health.

ACS Style

Marianna Caterino; Margherita Ruoppolo; Michele Costanzo; Lucia Albano; Daniela Crisci; Giovanni Sotgiu; Laura Saderi; Andrea Montella; Flavia Franconi; Ilaria Campesi. Sex Affects Human Premature Neonates’ Blood Metabolome According to Gestational Age, Parenteral Nutrition, and Caffeine Treatment. Metabolites 2021, 11, 158 .

AMA Style

Marianna Caterino, Margherita Ruoppolo, Michele Costanzo, Lucia Albano, Daniela Crisci, Giovanni Sotgiu, Laura Saderi, Andrea Montella, Flavia Franconi, Ilaria Campesi. Sex Affects Human Premature Neonates’ Blood Metabolome According to Gestational Age, Parenteral Nutrition, and Caffeine Treatment. Metabolites. 2021; 11 (3):158.

Chicago/Turabian Style

Marianna Caterino; Margherita Ruoppolo; Michele Costanzo; Lucia Albano; Daniela Crisci; Giovanni Sotgiu; Laura Saderi; Andrea Montella; Flavia Franconi; Ilaria Campesi. 2021. "Sex Affects Human Premature Neonates’ Blood Metabolome According to Gestational Age, Parenteral Nutrition, and Caffeine Treatment." Metabolites 11, no. 3: 158.

Review article
Published: 05 March 2021 in Respiratory Medicine
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Non-pharmacological interventions and tracing-testing strategy proved insufficient to reduce SARS-CoV-2 spreading worldwide. Several vaccines with different mechanisms of action are currently under development. This review describes the potential target antigens evaluated for SARS-CoV-2 vaccine in the context of both conventional and next-generation platforms. We reported experimental data from phase-3 trials with a focus on different definitions of efficacy as well as factors affecting real-life effectiveness of SARS-CoV-2 vaccination, including logistical issues associated to vaccine availability, delivery, and immunization strategies. On this background, new variants of SARS-CoV-2 are discussed. We also provided a critical view on vaccination in special populations at higher risk of infection or severe disease as elderly people, pregnant women and immunocompromised patients. A final paragraph addresses safety on the light of the unprecedented reduction of length of the vaccine development process and faster authorization.

ACS Style

Francesco Blasi; Andrea Gramegna; Giovanni Sotgiu; Laura Saderi; Antonio Voza; Stefano Aliberti; Francesco Amati. SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity. Respiratory Medicine 2021, 180, 106355 -106355.

AMA Style

Francesco Blasi, Andrea Gramegna, Giovanni Sotgiu, Laura Saderi, Antonio Voza, Stefano Aliberti, Francesco Amati. SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity. Respiratory Medicine. 2021; 180 ():106355-106355.

Chicago/Turabian Style

Francesco Blasi; Andrea Gramegna; Giovanni Sotgiu; Laura Saderi; Antonio Voza; Stefano Aliberti; Francesco Amati. 2021. "SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity." Respiratory Medicine 180, no. : 106355-106355.

Review
Published: 28 January 2021 in Pulmonology
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The scientific debate on the criteria guiding hospitalization of tuberculosis (TB) and COVID-19 patients is ongoing. The aim of this review is to present the available evidence on admission for TB and TB/COVID-19 patients and discuss the criteria guiding hospitalization. Furthermore, recommendations are made as derived from recently published World Health Organization documents, based on Global Tuberculosis Network (GTN) expert opinion. The core published documents and guidelines on the topic have been reviewed. The proportion of new TB cases admitted to hospital ranges between 50% and 100% while for multidrug-resistant (MDR) TB patients it ranges between 85 and 100% globally. For TB patients with COVID-19 the proportion of cases admitted is 58%, probably reflecting different scenarios related to the diagnosis of COVID-19 before, after or at the same time of the active TB episode. The hospital length of stay for drug-susceptible TB ranges from 20 to 60 days in most of countries, ranging from a mean of 10 days (USA) to around 90 days in the Russian Federation. Hospitalization is longer for MDR-TB (50–180 days). The most frequently stated reasons for recommending hospital admission include: severe TB, infection control concerns, co-morbidities and drug adverse events which cannot be managed at out-patient level. The review also provides suggestions on hospital requirements for safe admissions as well as patient discharge criteria, while underlining the relevance of patient-centred care through community/home-based care.

ACS Style

Giovanni Battista Migliori; Dina Visca; Martin Van Den Boom; Simon Tiberi; Denise Rossato Silva; Rosella Centis; Lia D’Ambrosio; Tania Thomas; Emanuele Pontali; Laura Saderi; H. Simon Schaaf; Giovanni Sotgiu. Tuberculosis, COVID-19 and hospital admission: Consensus on pros and cons based on a review of the evidence. Pulmonology 2021, 27, 248 -256.

AMA Style

Giovanni Battista Migliori, Dina Visca, Martin Van Den Boom, Simon Tiberi, Denise Rossato Silva, Rosella Centis, Lia D’Ambrosio, Tania Thomas, Emanuele Pontali, Laura Saderi, H. Simon Schaaf, Giovanni Sotgiu. Tuberculosis, COVID-19 and hospital admission: Consensus on pros and cons based on a review of the evidence. Pulmonology. 2021; 27 (3):248-256.

Chicago/Turabian Style

Giovanni Battista Migliori; Dina Visca; Martin Van Den Boom; Simon Tiberi; Denise Rossato Silva; Rosella Centis; Lia D’Ambrosio; Tania Thomas; Emanuele Pontali; Laura Saderi; H. Simon Schaaf; Giovanni Sotgiu. 2021. "Tuberculosis, COVID-19 and hospital admission: Consensus on pros and cons based on a review of the evidence." Pulmonology 27, no. 3: 248-256.

Review article
Published: 15 December 2020 in Current Research in Pharmacology and Drug Discovery
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Even if major improvements in therapeutic regimens and treatment outcomes have been progressively achieved, tuberculosis (TB) remains the leading cause of death from a single infectious microorganism. To improve TB treatment success as well as patients' quality of life, drug-drug-interactions (DDIs) need to be wisely managed. Comprehensive knowledge of anti-TB drugs, pharmacokinetics and pharmacodynamic (PK/PD) parameters, potential patients’ changes in absorption and distribution, possible side effects and interactions, is mandatory to built effective anti-TB regimens. Optimization of treatments and adherence to international guidelines can help bend the curve of TB-related mortality and, ultimately, decrease the likelihood of treatment failure and drop-out during anti-TB treatment. Aim of this paper is to describe the most relevant DDIs between anti-TB and other drugs used in daily clinical practice, providing an updated and “easy-to-use” guide to minimize adverse effects, drop-outs and, in the long run, increase treatment success.

ACS Style

Niccolò Riccardi; Diana Canetti; Paola Rodari; Giorgio Besozzi; Laura Saderi; Marco Dettori; Luigi R. Codecasa; Giovanni Sotgiu. Tuberculosis and pharmacological interactions: A narrative review. Current Research in Pharmacology and Drug Discovery 2020, 2, 100007 .

AMA Style

Niccolò Riccardi, Diana Canetti, Paola Rodari, Giorgio Besozzi, Laura Saderi, Marco Dettori, Luigi R. Codecasa, Giovanni Sotgiu. Tuberculosis and pharmacological interactions: A narrative review. Current Research in Pharmacology and Drug Discovery. 2020; 2 ():100007.

Chicago/Turabian Style

Niccolò Riccardi; Diana Canetti; Paola Rodari; Giorgio Besozzi; Laura Saderi; Marco Dettori; Luigi R. Codecasa; Giovanni Sotgiu. 2020. "Tuberculosis and pharmacological interactions: A narrative review." Current Research in Pharmacology and Drug Discovery 2, no. : 100007.

Research letters
Published: 28 August 2020 in European Respiratory Journal
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Utility and safety of bronchoscopy during the SARS-CoV-2 outbreakhttps://bit.ly/3ish52k

ACS Style

Michele Mondoni; Giuseppe Francesco Sferrazza Papa; Rocco Francesco Rinaldo; Paola Faverio; Almerico Marruchella; Francesca D'arcangelo; Alberto Pesci; Simone Pasini; Sonia Henchi; Giuseppe Cipolla; Francesco Tarantini; Lisa Giuliani; Fabiano Di Marco; Laura Saracino; Stefano Tomaselli; Angelo Corsico; Stefano Gasparini; Martina Bonifazi; Lina Zuccatosta; Laura Saderi; Giulia Pellegrino; Matteo Davì; Paolo Carlucci; Stefano Centanni; Giovanni Sotgiu. Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study. European Respiratory Journal 2020, 56, 2002767 .

AMA Style

Michele Mondoni, Giuseppe Francesco Sferrazza Papa, Rocco Francesco Rinaldo, Paola Faverio, Almerico Marruchella, Francesca D'arcangelo, Alberto Pesci, Simone Pasini, Sonia Henchi, Giuseppe Cipolla, Francesco Tarantini, Lisa Giuliani, Fabiano Di Marco, Laura Saracino, Stefano Tomaselli, Angelo Corsico, Stefano Gasparini, Martina Bonifazi, Lina Zuccatosta, Laura Saderi, Giulia Pellegrino, Matteo Davì, Paolo Carlucci, Stefano Centanni, Giovanni Sotgiu. Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study. European Respiratory Journal. 2020; 56 (4):2002767.

Chicago/Turabian Style

Michele Mondoni; Giuseppe Francesco Sferrazza Papa; Rocco Francesco Rinaldo; Paola Faverio; Almerico Marruchella; Francesca D'arcangelo; Alberto Pesci; Simone Pasini; Sonia Henchi; Giuseppe Cipolla; Francesco Tarantini; Lisa Giuliani; Fabiano Di Marco; Laura Saracino; Stefano Tomaselli; Angelo Corsico; Stefano Gasparini; Martina Bonifazi; Lina Zuccatosta; Laura Saderi; Giulia Pellegrino; Matteo Davì; Paolo Carlucci; Stefano Centanni; Giovanni Sotgiu. 2020. "Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study." European Respiratory Journal 56, no. 4: 2002767.

Journal article
Published: 21 August 2020 in Journal of Clinical Medicine
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The aim of this case–control study was to evaluate maternal–fetal and neonatal clinical outcomes in a group of patients with gestational diabetes mellitus (GDM) and pregestational diabetes such as diabetes mellitus type 1 (DM1) and diabetes mellitus type 2 (DM2) and compare them with those of patients without diabetes. A total of 414 pregnant women, nulliparous and multiparous, with single pregnancy were recruited. The selected patients were divided into two groups. Among 207 patients (group cases), 183 had GDM and 24 pregestational diabetes (of which n = 17 diagnosed with DM1 and n = 7 with diagnosis of DM2). Two-hundred-seven patients with a negative pathologic history of GDM, DM1 and DM2 represented the population of controls (group control). We reported an incidence of preterm delivery of 23.2% in the group of cases, of 18.3% in the group of patients with GDM and 66.7% in the group of patients DM1/2. Fetal growth disorders, such as intrauterine growth retardation (IUGR), small for gestational age (SGA), fetal macrosomia, were detected in four fetuses out of 207 (1.93%) in the control group and 20 fetuses out of 207 in the case group (9.67%, p-value 0.001); of these 16 of 183 fetuses of the GDM group (8.74%, p-value 0.002) and 4 of 24 fetuses of the DM1/2 group (16.67%, p-value 0.005). A very strong correlation between diabetes mellitus type 1 and preeclampsia (p-value < 0.0001) was observed. Close monitoring of pregnant women with diabetes is recommended to prevent maternal–fetal and neonatal complications.

ACS Style

Giampiero Capobianco; Alessandra Gulotta; Giulio Tupponi; Francesco Dessole; Maddalena Pola; Giuseppe Virdis; Marco Petrillo; Valerio Mais; Giorgio Olzai; Roberto Antonucci; Laura Saderi; Pier Luigi Cherchi; Salvatore Dessole; Giovanni Sotgiu. Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study. Journal of Clinical Medicine 2020, 9, 2707 .

AMA Style

Giampiero Capobianco, Alessandra Gulotta, Giulio Tupponi, Francesco Dessole, Maddalena Pola, Giuseppe Virdis, Marco Petrillo, Valerio Mais, Giorgio Olzai, Roberto Antonucci, Laura Saderi, Pier Luigi Cherchi, Salvatore Dessole, Giovanni Sotgiu. Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study. Journal of Clinical Medicine. 2020; 9 (9):2707.

Chicago/Turabian Style

Giampiero Capobianco; Alessandra Gulotta; Giulio Tupponi; Francesco Dessole; Maddalena Pola; Giuseppe Virdis; Marco Petrillo; Valerio Mais; Giorgio Olzai; Roberto Antonucci; Laura Saderi; Pier Luigi Cherchi; Salvatore Dessole; Giovanni Sotgiu. 2020. "Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study." Journal of Clinical Medicine 9, no. 9: 2707.

Research letters
Published: 03 August 2020 in European Respiratory Journal
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Helmet CPAP treatment fails in up to 44% of patients with moderate-to-severe hypoxaemic acute respiratory failure due to COVID-19 pneumoniahttps://bit.ly/3g7FAB8

ACS Style

Stefano Aliberti; Dejan Radovanovic; Filippo Billi; Giovanni Sotgiu; Matteo Costanzo; Tommaso Pilocane; Laura Saderi; Andrea Gramegna; Angelo Rovellini; Luca Perotto; Valter Monzani; Pierachille Santus; Francesco Blasi. Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study. European Respiratory Journal 2020, 56, 2001935 .

AMA Style

Stefano Aliberti, Dejan Radovanovic, Filippo Billi, Giovanni Sotgiu, Matteo Costanzo, Tommaso Pilocane, Laura Saderi, Andrea Gramegna, Angelo Rovellini, Luca Perotto, Valter Monzani, Pierachille Santus, Francesco Blasi. Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study. European Respiratory Journal. 2020; 56 (4):2001935.

Chicago/Turabian Style

Stefano Aliberti; Dejan Radovanovic; Filippo Billi; Giovanni Sotgiu; Matteo Costanzo; Tommaso Pilocane; Laura Saderi; Andrea Gramegna; Angelo Rovellini; Luca Perotto; Valter Monzani; Pierachille Santus; Francesco Blasi. 2020. "Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study." European Respiratory Journal 56, no. 4: 2001935.

Review
Published: 01 August 2020 in Infection and Drug Resistance
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The emerge of drug-resistant tuberculosis (TB) strain in recent decades is hampering the efforts of the international community to eliminate the disease worldwide. The World Health Organization (WHO) has drafted many strategies to achieve this ambitious goal. In the very beginning, the aim was to standardize inadequate regimens used in many countries and, thereafter, evolved to tackle the social determinants which hinder TB elimination. However, following the path of narrowing the clinical vision to deal with TB, there is an increased need to personalize the treatment considering both patients and pathogen unique characteristics. In our narrative review, we report the advantages and the backwards in developing a method to implement the concept of precision medicine to the treatment of TB. In this dissertation, we highlight the importance to address different aspects of the diseases encompassing the host and pathogen features, as well as the needs to further implement an adequate follow-up based on the available resources. Nevertheless, many things may hamper the vision of precision medicine in TB, such as the complexity and the costs to develop novel compounds and the costs related to global-scale implementation of patient-centered follow-up. To achieve the ambitious goal of TB elimination, a radical change in TB treatment is needed in order to give a more comprehensive approach based both on patients’ peculiarities and driven by drug susceptibility tests and whole-genome sequencing.

ACS Style

Niccolò Riccardi; Simone Villa; Riccardo Alagna; Andrea Giacomelli; Laura Saderi; Daniela Maria Cirillo; Giorgio Besozzi; Giovanni Sotgiu; Luigi Codecasa. Advantages and Challenges of Tailored Regimens for Drug-Resistant Tuberculosis: A StopTB Italia Look into the Future. Infection and Drug Resistance 2020, ume 13, 2795 -2800.

AMA Style

Niccolò Riccardi, Simone Villa, Riccardo Alagna, Andrea Giacomelli, Laura Saderi, Daniela Maria Cirillo, Giorgio Besozzi, Giovanni Sotgiu, Luigi Codecasa. Advantages and Challenges of Tailored Regimens for Drug-Resistant Tuberculosis: A StopTB Italia Look into the Future. Infection and Drug Resistance. 2020; ume 13 ():2795-2800.

Chicago/Turabian Style

Niccolò Riccardi; Simone Villa; Riccardo Alagna; Andrea Giacomelli; Laura Saderi; Daniela Maria Cirillo; Giorgio Besozzi; Giovanni Sotgiu; Luigi Codecasa. 2020. "Advantages and Challenges of Tailored Regimens for Drug-Resistant Tuberculosis: A StopTB Italia Look into the Future." Infection and Drug Resistance ume 13, no. : 2795-2800.

Journal article
Published: 25 June 2020 in European Respiratory Journal
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Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.

ACS Style

Catherine Wei Min Ong; Giovanni Battista Migliori; Mario Raviglione; Gavin Macgregor-Skinner; Giovanni Sotgiu; Jan-Willem Alffenaar; Simon Tiberi; Cornelia Adlhoch; Tonino Alonzi; Sophia Archuleta; Sergio Brusin; Emmanuelle Cambau; Maria Rosaria Capobianchi; Concetta Castilletti; Rosella Centis; Daniela M. Cirillo; Lia D'ambrosio; Giovanni Delogu; Susanna M. R. Esposito; Jose Figueroa; Jon S. Friedland; Benjamin Choon Heng Ho; Giuseppe Ippolito; Mateja Jankovic; Hannah Yejin Kim; Senia Rosales Klintz; Csaba Ködmön; Eleonora Lalle; Yee Sin Leo; Chi-Chiu Leung; Anne-Grete Märtson; Mario Giovanni Melazzini; Saeid Najafi Fard; Pasi Penttinen; Linda Petrone; Elisa Petruccioli; Emanuele Pontali; Laura Saderi; Miguel Santin; Antonio Spanevello; Reinout Van Crevel; Marieke J. Van Der Werf; Dina Visca; Miguel Viveiros; Jean-Pierre Zellweger; Alimuddin Zumla; Delia Goletti. Epidemic and pandemic viral infections: impact on tuberculosis and the lung. European Respiratory Journal 2020, 56, 2001727 .

AMA Style

Catherine Wei Min Ong, Giovanni Battista Migliori, Mario Raviglione, Gavin Macgregor-Skinner, Giovanni Sotgiu, Jan-Willem Alffenaar, Simon Tiberi, Cornelia Adlhoch, Tonino Alonzi, Sophia Archuleta, Sergio Brusin, Emmanuelle Cambau, Maria Rosaria Capobianchi, Concetta Castilletti, Rosella Centis, Daniela M. Cirillo, Lia D'ambrosio, Giovanni Delogu, Susanna M. R. Esposito, Jose Figueroa, Jon S. Friedland, Benjamin Choon Heng Ho, Giuseppe Ippolito, Mateja Jankovic, Hannah Yejin Kim, Senia Rosales Klintz, Csaba Ködmön, Eleonora Lalle, Yee Sin Leo, Chi-Chiu Leung, Anne-Grete Märtson, Mario Giovanni Melazzini, Saeid Najafi Fard, Pasi Penttinen, Linda Petrone, Elisa Petruccioli, Emanuele Pontali, Laura Saderi, Miguel Santin, Antonio Spanevello, Reinout Van Crevel, Marieke J. Van Der Werf, Dina Visca, Miguel Viveiros, Jean-Pierre Zellweger, Alimuddin Zumla, Delia Goletti. Epidemic and pandemic viral infections: impact on tuberculosis and the lung. European Respiratory Journal. 2020; 56 (4):2001727.

Chicago/Turabian Style

Catherine Wei Min Ong; Giovanni Battista Migliori; Mario Raviglione; Gavin Macgregor-Skinner; Giovanni Sotgiu; Jan-Willem Alffenaar; Simon Tiberi; Cornelia Adlhoch; Tonino Alonzi; Sophia Archuleta; Sergio Brusin; Emmanuelle Cambau; Maria Rosaria Capobianchi; Concetta Castilletti; Rosella Centis; Daniela M. Cirillo; Lia D'ambrosio; Giovanni Delogu; Susanna M. R. Esposito; Jose Figueroa; Jon S. Friedland; Benjamin Choon Heng Ho; Giuseppe Ippolito; Mateja Jankovic; Hannah Yejin Kim; Senia Rosales Klintz; Csaba Ködmön; Eleonora Lalle; Yee Sin Leo; Chi-Chiu Leung; Anne-Grete Märtson; Mario Giovanni Melazzini; Saeid Najafi Fard; Pasi Penttinen; Linda Petrone; Elisa Petruccioli; Emanuele Pontali; Laura Saderi; Miguel Santin; Antonio Spanevello; Reinout Van Crevel; Marieke J. Van Der Werf; Dina Visca; Miguel Viveiros; Jean-Pierre Zellweger; Alimuddin Zumla; Delia Goletti. 2020. "Epidemic and pandemic viral infections: impact on tuberculosis and the lung." European Respiratory Journal 56, no. 4: 2001727.

Journal article
Published: 25 June 2020 in European Respiratory Journal
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Andrea Gramegna; Stefano Aliberti; Oriol Sibila; Carlotta Di Francesco; Giovanni Sotgiu; Lidia Perea; Leonardo Terranova; Martina Oriano; Tommaso Pilocane; Laura Saderi; James D. Chalmers; Paola Marchisio; Francesco Blasi. Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study. European Respiratory Journal 2020, 56, 2001702 .

AMA Style

Andrea Gramegna, Stefano Aliberti, Oriol Sibila, Carlotta Di Francesco, Giovanni Sotgiu, Lidia Perea, Leonardo Terranova, Martina Oriano, Tommaso Pilocane, Laura Saderi, James D. Chalmers, Paola Marchisio, Francesco Blasi. Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study. European Respiratory Journal. 2020; 56 (6):2001702.

Chicago/Turabian Style

Andrea Gramegna; Stefano Aliberti; Oriol Sibila; Carlotta Di Francesco; Giovanni Sotgiu; Lidia Perea; Leonardo Terranova; Martina Oriano; Tommaso Pilocane; Laura Saderi; James D. Chalmers; Paola Marchisio; Francesco Blasi. 2020. "Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study." European Respiratory Journal 56, no. 6: 2001702.

Journal article
Published: 23 June 2020 in International Journal of Environmental Research and Public Health
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Objectives: Anal cancer is a rare disease. However, its incidence is increasing in some population groups. Infection caused by Human Papillomavirus (HPV) is strongly associated with the risk of anal cancer, whose variability depends on samples, histology, and HPV detection methods. The aim of the study was to assess prevalence and distribution of HPV genotypes in patients diagnosed with anal carcinoma. Methods: An observational, retrospective study was carried out in a tertiary care hospital in North Sardinia, Italy. Specimens of anal cancer diagnosed from 2002–2018 were selected. Demographic, epidemiological, and clinical variables were collected to assess their relationship with the occurrence of anal cancer. Results: The overall HPV positivity was 70.0% (21/30), with HPV-16 being the predominant genotype (~85%). The highest prevalence of anal cancer was in patients aged ≥55 years. HPV positivity was higher in women (p-value > 0.05) and in moderately differentiated samples (G2) (p-value < 0.05). p16INK4a and E6-transcript positivity were found in 57% and 24% of the HPV positive samples, respectively. The OS (overall survival) showed a not statistically significant difference in prognosis between HPV positive sand negatives (10, 47.6%, vs. 4, 44.4%; p-value = 0.25). Conclusions: HPV-DNA and p16INK4a positivity confirmed the role of HPV in anal carcinoma. Our findings could support the implementation and scale-up of HPV vaccination in males and females to decrease the incidence of HPV-associated cancers. Further studies are needed to better clarify the prognostic role of HPV/p16 status.

ACS Style

Narcisa Muresu; Giovanni Sotgiu; Laura Saderi; Illari Sechi; Antonio Cossu; Vincenzo Marras; Marta Meloni; Marianna Martinelli; Clementina Cocuzza; Francesco Tanda; Andrea Piana. Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region. International Journal of Environmental Research and Public Health 2020, 17, 4516 .

AMA Style

Narcisa Muresu, Giovanni Sotgiu, Laura Saderi, Illari Sechi, Antonio Cossu, Vincenzo Marras, Marta Meloni, Marianna Martinelli, Clementina Cocuzza, Francesco Tanda, Andrea Piana. Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region. International Journal of Environmental Research and Public Health. 2020; 17 (12):4516.

Chicago/Turabian Style

Narcisa Muresu; Giovanni Sotgiu; Laura Saderi; Illari Sechi; Antonio Cossu; Vincenzo Marras; Marta Meloni; Marianna Martinelli; Clementina Cocuzza; Francesco Tanda; Andrea Piana. 2020. "Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region." International Journal of Environmental Research and Public Health 17, no. 12: 4516.

Journal article
Published: 04 June 2020 in European Respiratory Journal
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IntroductionNeutrophilic inflammation is a major driver of bronchiectasis pathophysiology, and neutrophil elastase activity is the most promising biomarker evaluated in sputum to date. How active neutrophil elastase correlates with the lung microbiome in bronchiectasis is still unexplored. We aimed to understand whether active neutrophil elastase is associated with low microbial diversity and distinct microbiome characteristics.MethodsAn observational, cross-sectional study was conducted at the bronchiectasis programme of the Policlinico Hospital in Milan, Italy, where adults with bronchiectasis were enrolled between March 2017 and March 2019. Active neutrophil elastase was measured on sputum collected during stable state, microbiota analysed through 16S rRNA gene sequencing, molecular assessment of respiratory pathogens carried out through real-time PCR and clinical data collected.ResultsAmong 185 patients enrolled, decreasing α-diversity, evaluated through the Shannon entropy (ρ −0.37, p−1 (median 3.82, interquartile range 2.20–4.96) versus neutrophil elastase −1 (4.88, 3.68–5.80; pPseudomonas in the high-elastase group and with Streptococcus in the low-elastase group. Further confirmation of the association of Pseudomonas aeruginosa with elevated active neutrophil elastase was found based on standard culture and targeted real-time PCR.ConclusionsHigh levels of active neutrophil elastase are associated to low microbiome diversity and specifically to P. aeruginosa infection.

ACS Style

Martina Oriano; Andrea Gramegna; Leonardo Terranova; Giovanni Sotgiu; Imran Sulaiman; Luca Ruggiero; Laura Saderi; Benjamin Wu; James D. Chalmers; Leopoldo N. Segal; Paola Marchisio; Francesco Blasi; Stefano Aliberti. Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis. European Respiratory Journal 2020, 56, 2000769 .

AMA Style

Martina Oriano, Andrea Gramegna, Leonardo Terranova, Giovanni Sotgiu, Imran Sulaiman, Luca Ruggiero, Laura Saderi, Benjamin Wu, James D. Chalmers, Leopoldo N. Segal, Paola Marchisio, Francesco Blasi, Stefano Aliberti. Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis. European Respiratory Journal. 2020; 56 (4):2000769.

Chicago/Turabian Style

Martina Oriano; Andrea Gramegna; Leonardo Terranova; Giovanni Sotgiu; Imran Sulaiman; Luca Ruggiero; Laura Saderi; Benjamin Wu; James D. Chalmers; Leopoldo N. Segal; Paola Marchisio; Francesco Blasi; Stefano Aliberti. 2020. "Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis." European Respiratory Journal 56, no. 4: 2000769.

Journal article
Published: 12 May 2020 in European Respiratory Journal
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The use of inhaled corticosteroids (ICS) in patients with bronchiectasis is matter of debate [1]. International registries report up to 42% of bronchiectasis patients receiving ICS, although several guidelines recommend their prescription only in the presence of specific comorbidities ( e.g. , Allergic Bronchopulmonary Aspergillosis -ABPA-, asthma, COPD, and inflammatory bowel disease) or of eosinophilic inflammation [2,3]. Assessment of eosinophil counts in sputum is not considered, to date, a standard of care. Blood eosinophils have been shown to be a predictor of ICS response in COPD and asthma [4,5]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Prof. Aliberti reports grants and personal fees from Bayer Healthcare, grants and personal fees from Aradigm Corporation, grants and personal fees from Grifols, personal fees from Astra Zeneca, personal fees from Basilea, personal fees from Zambon, personal fees from Novartis, personal fees from Raptor, grants and personal fees from Chiesi, personal fees from Actavis UK Ltd, personal fees from Horizon, grants and personal fees from INSMED, outside the submitted work; .Dr. Aliberti reports grants and personal fees from Bayer Healthcare, grants and personal fees from Aradigm Corporation, grants and personal fees from Grifols, personal fees from Astra Zeneca, personal fees from Basilea, personal fees from Zambon, personal fees from Novartis, personal fees from Raptor, grants and personal fees from Chiesi, personal fees from Actavis UK Ltd, personal fees from Horizon, grants and personal fees from INSMED, outside the submitted work. Conflict of interest: Dr. Sotgiu has nothing to disclose. Conflict of interest: Dr. BLASI reports personal fees from ASTRAZENECA, grants from BAYER, grants and personal fees from CHIESI, personal fees from GSK, personal fees from GUIDOTTI MALESCI, personal fees from GRIFOLS, grants and personal fees from INSMED, personal fees from MENARINI, personal fees from NOVARTIS, personal fees from PFIZER, personal fees from SANOFI, personal fees from ZAMBON, outside the submitted work. Conflict of interest: Dr. Saderi has nothing to disclose. Conflict of interest: Dr Posadas has not any conflict of interest to declare Conflict of interest: Dr. Martinez-Garcia has received grants and fees from Zambon, Chiesi, Vitalire, Grifols, Novartis and TEVA

ACS Style

Stefano Aliberti; Giovanni Sotgiu; Francesco Blasi; Laura Saderi; Tomas Posadas; Miguel Angel Martinez Garcia. Blood eosinophils predict inhaled fluticasone response in bronchiectasis. European Respiratory Journal 2020, 56, 2000453 .

AMA Style

Stefano Aliberti, Giovanni Sotgiu, Francesco Blasi, Laura Saderi, Tomas Posadas, Miguel Angel Martinez Garcia. Blood eosinophils predict inhaled fluticasone response in bronchiectasis. European Respiratory Journal. 2020; 56 (2):2000453.

Chicago/Turabian Style

Stefano Aliberti; Giovanni Sotgiu; Francesco Blasi; Laura Saderi; Tomas Posadas; Miguel Angel Martinez Garcia. 2020. "Blood eosinophils predict inhaled fluticasone response in bronchiectasis." European Respiratory Journal 56, no. 2: 2000453.

Journal article
Published: 25 January 2020 in Vaccines
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The aim of this study was to assess the role of a human papilloma virus (HPV) vaccine after loop electrosurgical excision procedure (LEEP) in reducing recurrent cervical dysplasia. A series of 503 women with cervical dysplasia received LEEP between January 2012 and October 2018. Of these patients, 379 were treated between January 2012 and June 2017, thus ensuring an adequate follow-up time. We made three attempts to establish telephone contact with each patient; 77 women did not respond and were excluded from the final study population, which consisted of 302 patients. One hundred eighty-two (60.7%) women were vaccinated with an HPV vaccine within 4 weeks of LEEP and 103 (34.3%) were followed up with but not vaccinated. Recurrence of cervical dysplasia requiring a further LEEP procedure occurred in 30 (10.5%) women, of whom 17 (16.5%) were not vaccinated and 13 (7.1%) were vaccinated (p-value = 0.010). At univariate analysis, HPV vaccination after LEEP (odds ratio (OR) = 0.4, p-value = 0.020) emerged as an independent protective factor. Choosing as an outcome of the analysis only recurrence as severe cervical lesions, the protective role of HPV vaccination after LEEP was found to be much more relevant with an odds ratio of 0.2 (95% CI = 0.1–0.6, p-value = 0.02). Administration of an HPV vaccine after LEEP seems to reduce the risk of recurrence, thus suggesting that HPV vaccination has a role as an adjuvant treatment after LEEP.

ACS Style

Marco Petrillo; Margherita Dessole; Elettra Tinacci; Laura Saderi; Narcisa Muresu; Giampiero Capobianco; Antonio Cossu; Salvatore Dessole; Giovanni Sotgiu; Andrea Piana. Efficacy of HPV Vaccination in Women Receiving LEEP for Cervical Dysplasia: A Single Institution’s Experience. Vaccines 2020, 8, 45 .

AMA Style

Marco Petrillo, Margherita Dessole, Elettra Tinacci, Laura Saderi, Narcisa Muresu, Giampiero Capobianco, Antonio Cossu, Salvatore Dessole, Giovanni Sotgiu, Andrea Piana. Efficacy of HPV Vaccination in Women Receiving LEEP for Cervical Dysplasia: A Single Institution’s Experience. Vaccines. 2020; 8 (1):45.

Chicago/Turabian Style

Marco Petrillo; Margherita Dessole; Elettra Tinacci; Laura Saderi; Narcisa Muresu; Giampiero Capobianco; Antonio Cossu; Salvatore Dessole; Giovanni Sotgiu; Andrea Piana. 2020. "Efficacy of HPV Vaccination in Women Receiving LEEP for Cervical Dysplasia: A Single Institution’s Experience." Vaccines 8, no. 1: 45.

Journal article
Published: 25 January 2020 in Journal of Orthopaedics
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To assess the resumption of physical activity after knee replacement. retrospective study. 118 patients were included in the final analysis. A resumption of >93% of the activities performed before surgery was observed. Logistic regression analysis did not show any significant associations between postoperatory activity and epidemiological and clinical variables except the function perceived by the patient. the resumption of physical activity and sport is a paramount expectation for active patients. A clearer definition of physical activity and sports realistically achievable after a knee prosthesis is necessary but not yet fully available.

ACS Style

Francesco Pisanu; Matteo Andreozzi; Federico Costagli; Gianfilipo Caggiari; Laura Saderi; Giovanni Sotgiu; Andrea Fabio Manunta. Resumption of physical activity and sport after knee replacement. Journal of Orthopaedics 2020, 20, 247 -250.

AMA Style

Francesco Pisanu, Matteo Andreozzi, Federico Costagli, Gianfilipo Caggiari, Laura Saderi, Giovanni Sotgiu, Andrea Fabio Manunta. Resumption of physical activity and sport after knee replacement. Journal of Orthopaedics. 2020; 20 ():247-250.

Chicago/Turabian Style

Francesco Pisanu; Matteo Andreozzi; Federico Costagli; Gianfilipo Caggiari; Laura Saderi; Giovanni Sotgiu; Andrea Fabio Manunta. 2020. "Resumption of physical activity and sport after knee replacement." Journal of Orthopaedics 20, no. : 247-250.

Review
Published: 18 January 2020 in International Journal of Environmental Research and Public Health
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Enteric fever is a foodborne infectious disease caused by Salmonella enterica serotypes Typhi and Paratyphi A, B and C. The high incidence in low income countries can increase the risk of disease in travelers coming from high income countries. Pre-travel health advice on hygiene and sanitation practices and vaccines can significantly reduce the risk of acquiring infections. Although the majority of the cases are self-limiting, life-threatening complications can occur. Delayed diagnosis and cases of infections caused by multi-drug resistant strains can complicate the clinical management and affect the prognosis. More international efforts are needed to reduce the burden of disease in low income countries, indirectly reducing the risk of travelers in endemic settings. Surveillance activities can help monitor the epidemiology of cases caused by drug-susceptible and resistant strains.

ACS Style

Narcisa Muresu; Giovanni Sotgiu; Bianca Maria Are; Andrea Cossu; Clementina Cocuzza; Marianna Martinelli; Sergio Babudieri; Riccardo Are; Marco Dettori; Antonio Azara; Laura Saderi; Andrea Piana. Travel-Related Typhoid Fever: Narrative Review of the Scientific Literature. International Journal of Environmental Research and Public Health 2020, 17, 615 .

AMA Style

Narcisa Muresu, Giovanni Sotgiu, Bianca Maria Are, Andrea Cossu, Clementina Cocuzza, Marianna Martinelli, Sergio Babudieri, Riccardo Are, Marco Dettori, Antonio Azara, Laura Saderi, Andrea Piana. Travel-Related Typhoid Fever: Narrative Review of the Scientific Literature. International Journal of Environmental Research and Public Health. 2020; 17 (2):615.

Chicago/Turabian Style

Narcisa Muresu; Giovanni Sotgiu; Bianca Maria Are; Andrea Cossu; Clementina Cocuzza; Marianna Martinelli; Sergio Babudieri; Riccardo Are; Marco Dettori; Antonio Azara; Laura Saderi; Andrea Piana. 2020. "Travel-Related Typhoid Fever: Narrative Review of the Scientific Literature." International Journal of Environmental Research and Public Health 17, no. 2: 615.