Malaria is an infectious and parasitic disease caused by protozoa of the genus Plasmodium, which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in Plasmodium populations, leading to the search for potential new active compounds against the parasite. Thus, we aimed to evaluate the in vitro antiplasmodial activity and cytotoxicity of the hydroalcoholic extract of Jucá (Libidibia ferrea) in serial concentrations. Jucá was used in the form of a freeze-dried hydroalcoholic extract. For the cytotoxicity assay, the(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method with the WI-26VA4 human cell line was used. For the antiplasmodial activity, Plasmodium falciparum synchronized cultures were treated with serial concentrations (0.2 to 50 μg/mL) of the Jucá extract. In terms of the chemical composition of the Jucá extract, gas chromatography coupled to mass spectrometry measurements revealed the main compounds as ellagic acid, valoneic acid dilactone, gallotannin, and gallic acid. The Jucá hydroalcoholic extract did not show cytotoxic activity per MTT, with an IC₅₀ value greater than 100 µg/mL. Regarding the antiplasmodial activity, the Jucá extract presented an IC₅₀ of 11.10 µg/mL with a selective index of nine. Because of its antiplasmodial activity at the tested concentrations and low toxicity, the Jucá extract is presented as a candidate for herbal medicine in the treatment of malaria. To the best of our knowledge, this is the first report of antiplasmodial activity in Jucá.

Objective: this article aimed to identify the presence of suicidal ideation among schoolchildren in a municipality in the Lower Amazon, as well as the factors associated with this outcome. Methodology: this is a cross-sectional analytical study carried out with 363 students from October 2018 to February 2019. The data collected were worked on descriptive statistics, percentage distribution and the Chi-square and Fischer Exact tests. Results: the following variables showed statistical significance: female gender; age between 11 and 14 years; elementary school students; indigenous schoolchildren; they face their problems reasonably / poorly; have a bad relationship with the family; shows little / no interest in the school. Conclusion: this study showed a higher prevalence of suicidal ideation than the statistics found for this age group in other published studies, however, the variables that showed a statistical association with the presence of suicidal ideation mostly coincide with the variables found in other published studies.

In hospital units, the evaluation and pharmaceutical follow-up of medical prescriptions is an important source for pharmaceutical care and pharmaceutical clinical services. One common problem that has high hospital incidence rates is the occurrence of acute kidney injury (AKI). Pharmacovigilance among other activities is implemented in hospitals for the purpose of receiving and monitoring reports of adverse effects related to medications administered to patients. The survey evaluated the incidence of acute kidney injury in patients hospitalized and exposed to antimicrobials in a public hospital in the state of Pará, Brazil. A prospective and observational cohort was carried out, whose outcome of interest is the occurrence of AKI in patients admitted to the hospital between October 2018 and January 2019. The data were recorded and stored in a database, then descriptive analysis was performed in the GraphPad Prism 6.0 program. Quantitative variables were expressed as standard deviation (SD) of the mean and the number of cases as a percentage. We collected data from 70 patients who were admitted to the hospital and needed to use any of the antimicrobials selected in the observation period during hospital treatment. The survey results showed that mostly male (64.29%; n = 45). Age ranged from 19 to 96 years, with a mean of 52.49 years (SD = 20.31). The patients included were mostly from the oncology clinic (34.29%; n = 24) those that had had surgery (27.14%; n = 19). Most critically ill patients admitted to the adult ICU (26.47 %; n = 9) developed AKI. Regarding the number of medications used by patients, there was a variation from 5 to 17, with a mean of 10.26 (SD = 2.90) medications prescribed per patient. In the data regarding the antimicrobials, most patients took ceftriaxone (n = 29), cefepime (n = 27) and piperacillin/tazobactam (n = 23). In terms of the number of antimicrobials prescribed per patient, 60% (n = 42) of patients took only one, 30% (n = 21) took two and 10% (n = 7) took three or more antimicrobials for treatment of infections. The plasma concentrations of vancomycin ranged from 3.0 µg/mL to 22.5 µg/mL. Of the 10 samples collected, 10.0% (n = 1) were above the therapeutic range established by the literature (between 10 to 20 µg/mL), 30.0% (n = 3) were within the reference values and 60.0% (n = 6) of the patients had values below the reference values. Patients who developed AKI (60.0%; n = 6) during vancomycin use had concentration values between 3 µg/mL and 15.9 µg/mL, most of whom had values below the recommended therapeutic range. Of these patients with AKI, 83.33% (n = 5) used more than one nephrotoxic antimicrobial during hospital treatment. The concentrations of patients who were not diagnosed with AKI (40.0%; n = 4) ranged from 3.0 µg/mL to 22.5 µg/mL.