Background/Objectives: To systematically evaluate scientific evidence related to the influence of psychological stress on the response to periodontal treatment. Methods: PubMed/NCBI (National Center for Biotechnology Information, US National Library of Medicine), Web of Science (ClarivateTM), EBSCOHost, SCOPUS, and ProQuest databases were searched for published clinical studies in English up to May 2024. The quality of each study was assessed using the Ottawa–Newcastle scale. Results: Of 803 relevant articles identified, 8 were included in the qualitative synthesis qualitative synthesis. These studies involved 445 patients who completed the follow-up period, ranging from 6 weeks to 6 months. Stressed patients were more likely to experience higher levels of PPD and BOP compared to non-stressed patients. In total, 75% of the included studies showed a positive relationship between stress and response to NSPT, 12.5% observed a negative relationship, and the remaining 12.5% found some degree of relationship in the results of clinical periodontal parameters. The level of evidence is categorized according to the quality of the synthesis presented. Conclusions: There is a positive correlation between psychological stress and periodontal treatment response, indicating that stress may negatively influence the clinical outcomes of NSPT. Stress may reduce the inflammatory response, which is crucial for eliminating periodontal micropathogens after periodontal treatment.

Background: The interaction between stress and periodontal treatment is a topic of growing interest. It stands out as a field of research that sheds light on the complexity of oral health in individuals subjected to high levels of emotional stress. Objective: This paper aims to provide a protocol for a systematic review to examine the scientific evidence related to the influence of psychological stress on the response to periodontal treatment. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be followed, and the study is based on a formulation of PECO (Participants, Exposure, Comparators, and Outcomes) questions. This systematic review will involve a literature search covering studies published from January 2000 to May 2024. It will include searching the PubMed, Web of Science, EBSCOHost, Scopus, and ProQuest databases to identify relevant studies. After selection, data extraction and quality assessment (using the Ottawa-Newcastle Scale) of the included studies will be carried out. The objective is to integrate high-quality evidence on how psychological stress impacts the outcomes of periodontal treatment. Depending on the number and methodological consistency of included studies, the results may be presented by meta-analysis or qualitative synthesis. Results: The current stage of the study consists of selecting studies for the systematic review as outlined by this protocol. The search, screening, and data extraction began in January 2024. The final results are expected by July 2024, with final manuscript submission planned for November 2024. Conclusions: This review will help clarify how psychological factors, such as stress, influence the results of periodontal treatment, providing valuable guidelines for future research and helping clinicians make decisions about the best treatment options for patients. Trial Registration: Open Science Framework (OSF) Registries qfs6p; https://osf.io/qfs6p International Registered Report Identifier (IRRID): PRR1-10.2196/56765

This review was performed to analyze evidence from the scientific literature of the adjunctive effect of probiotics in the treatment of peri-implant mucositis (PiM). Only randomized clinical trials evaluating the effect of probiotics as an adjunct to mechanical debridement in PiM were included. A search was performed in PubMed/MEDLINE, LILACS, ScienceDirect, and Web of Science to identify articles published in English up to January 2023. The quality of the studies was evaluated using the JADAD scale, and the risk of bias was assessed with the Cochrane Collaboration assessment tool. Of the 159 potentially relevant studies, only 9 studies were included. The most commonly used strain was Lactobacillus reuteri, and the meta-analysis was conducted on studies with a follow-up period of 3 to 6 months, observing an overall effect on the reduction of bleeding on probing (BOP) at 3 and 6 months (WMD = −1.13, 95% CI = −1.95 to −0.30, p = 0.007; and WMD = −1.32, 95% CI = −2.15 to −0.48, p = 0.002), plaque index (PI) at 3 months (WMD = −1.22, 95% CI = −2.25 to −0.19, p = 0.02), and probing pocket depth (PPD) at 3 and 6 months, which was statistically significant in favor of the probiotic group (WMD = −1.34, 95% CI = −2.42 to −0.25, p = 0.02 and WMD = −1.36, 95% CI = −2.61 to −0.11, p = 0.03). On the other hand, there were no significant changes in the subgingival microflora around the implants with the use of probiotics. Probiotic therapy, as an adjunct to mechanical debridement, promotes a greater reduction in BOP, PPD, and PI, in relation to the control group without probiotics.

Salivary biomarkers have been explored as potential non-invasive tools for the diagnosis and monitoring of inflammatory bowel diseases (IBD), including Crohn’s Disease (CD) and Ulcerative Colitis (UC). This study presents a scoping review and evidence mapping on the use of saliva as a matrix in which biomarkers can be identified for these conditions. A systematic search of multiple databases and studies was conducted until 28 January 2025, resulting in the selection of 12 relevant articles. The quantified evidence synthesis identified eight molecular and microbial categories. Of these, four classes, including cytokines, microRNAs, calprotectin, and the microbiome, have demonstrated the most consistent potential. Alterations in these biomarkers, such as an increase in the Prevotella genus within the microbiome, and elevated PSMA7 levels, may reflect disruptions in intestinal barrier integrity and immune response. However, factors such as oral health status, hygiene habits, and medication must be carefully considered. Therefore, further clinical research is essential to validate specific biomarkers.

BACKGROUND The interaction between stress and periodontal treatment is a topic of growing interest. It stands out as a field of research that sheds light on the complexity of oral health in individuals subjected to high levels of emotional stress. OBJECTIVE This paper aims to provide a protocol for a systematic review to examine the scientific evidence related to the influence of psychological stress on the response to periodontal treatment. METHODS The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be followed, and the study is based on a formulation of PECO (Participants, Exposure, Comparators, and Outcomes) questions. This systematic review will involve a literature search covering studies published from January 2000 to May 2024. It will include searching the PubMed, Web of Science, EBSCOHost, Scopus, and ProQuest databases to identify relevant studies. After selection, data extraction and quality assessment (using the Ottawa-Newcastle Scale) of the included studies will be carried out. The objective is to integrate high-quality evidence on how psychological stress impacts the outcomes of periodontal treatment. Depending on the number and methodological consistency of included studies, the results may be presented by meta-analysis or qualitative synthesis. RESULTS The current stage of the study consists of selecting studies for the systematic review as outlined by this protocol. The search, screening, and data extraction began in January 2024. The final results are expected by July 2024, with final manuscript submission planned for November 2024. CONCLUSIONS This review will help clarify how psychological factors, such as stress, influence the results of periodontal treatment, providing valuable guidelines for future research and helping clinicians make decisions about the best treatment options for patients. CLINICALTRIAL Open Science Framework (OSF) Registries qfs6p; https://osf.io/qfs6p INTERNATIONAL REGISTERED REPORT PRR1-10.2196/56765

Background: Although bone tissue possesses inherent regenerative capacity, critical-sized defects require grafts for complete functional repair. This in vivo study evaluated the bone repair process using laser photobiomodulation therapy (PBM) in defects filled with a combination of hydroxyapatite, β-tricalcium phosphate and heterologous fibrin biopolymer (HFB). Methods: Thirty male rats were divided into three groups: biomaterial alone (BG), biomaterial + HFB (BBG), and biomaterial + HFB + PBM (BBPG). A 5-mm circular calvarial osteotomy was performed and filled according to each protocol. In BBPG, an 830-nm laser was applied immediately post-surgery and three times weekly until euthanasia at 14 or 42 days. Analyses included micro-CT, histomorphology, histomorphometry, and polarized light microscopy of collagen fibers. Results: Micro-CT showed centripetal bone regeneration restricted to defect margins, with biomaterial particles persisting centrally. Histologically, new bone progressed from immature trabecular architecture at day 14 to a mature lamellar conformation by day 42, notably in BBPG. All groups showed a significant temporal increase in new bone percentage. BBPG demonstrated superior bone growth at 42 days (26.64 ± 2.15%) compared to BG (14.85 ± 1.63%) and BBG (20.05 ± 1.70%). The birefringence of the collagen fibers showed a color transition from red to yellowish-green during the analyzed periods. Conclusion: The combination of the biomaterial, fibrin biopolymer and photobiomodulation significantly enhanced bone defect repair and matrix maturation without barrier membranes, presenting high translational potential for cost-effective clinical applications in regenerative medicine.