Ecological sensitivity is an essential indicator for measuring the degree of ecological fragility of a region, and traditional highway routing ignores the ecological benefits of regional nature, which causes irreversible impacts on the natural environment. Based on the AHP method, this paper carries out a comprehensive assessment of the ecological sensitivity of the K0+000~K56+438 section of the Guanzhuang Tourist Highway in the Zhangjiajie Wuling Mountain Area from 2000 to 2020, and it utilizes the spatial autocorrelation analysis method to reveal the pattern of its spatial and temporal changes in ecological sensitivity. The following results were obtained. (1) The ecological condition of the study area is gradually improving, and the areas with higher sensitivity are mainly distributed in the northeast and southwest of the study area. (2) The ecological sensitivity of the study area has strong spatial autocorrelation, but the autocorrelation has been reduced in recent years, and the distribution of the ecological sensitivity has been gradually discretized. (3) There are problems of high ecological risk and construction difficulty in the traditional highway route selection scheme of the A line. The optimized route selection scheme, the K line, can effectively avoid highly sensitive areas by adjusting the route and bridge settings. Finally, the article proposes engineering construction suitability and ecological restoration strategies for different road sections regarding vegetation cover, landscape risk, and geological hazards. This study establishes a set of comprehensive technical chains for tourism highway routing in ecologically fragile areas based on the spatial and temporal evolution of sensitivity, which provides new ideas for traditional highway routing and is of great significance for maintaining the balance and stability of ecosystems within the road area.

As human activities increasingly encroach on ecologically sensitive lake zones, China’s lake-ring urban agglomerations struggle to balance the intensifying human footprint (HF) and declining habitat quality (EQ). Addressing the spatiotemporal interactions between HF and EQ is essential for achieving human–environment coordination. This study examined five major freshwater lake-ring urban agglomerations in China during the period from 2000 to 2020 and developed an HF–EQ assessment framework. First, the coupling coordination degree (CCD) model quantified the spatiotemporal coupling between HF and EQ. Second, GeoDetector identified how HF and EQ interact to influence CCD. Finally, the four-quadrant static model and CCD change rate index formed a dual-dimensional management framework. The results indicate that the spatiotemporal evolution patterns of HF and EQ are highly complementary, exhibiting a significant coupling interaction. High-CCD zones expanded from lakeside urban areas and transport corridors, while low-CCD zones remained in remote, forested areas. HF factors such as GDP, land use intensity, and nighttime lights dominated CCD dynamics, while EQ-related factors showed increasing interaction effects. Five human–environment coordination zones were identified based on the static and dynamic characteristics of HF and EQ. Synergy efficiency zones had the highest coordination with diverse land use. Ecological conservation potential zones were found in low-disturbance hilly regions. Synergy restoration zones were concentrated in croplands and urban–rural fringe areas. Imbalance regulation zones were in forest areas under development pressure. Conflict alert zones were concentrated in urban cores, transport corridors, and lakeshore belts. These findings offer insights for global human–environment coordination in lake regions.