Background/Objectives: The aim of this pilot study is to qualitatively describe the use of life history questionnaires in an acute neurorehabilitation setting to define individualised goals of care for patients with clinical cognitive motor dissociation and to determine to what extent the information they contain influences the care and management provided by the team. Methods: Using the patient records of our sample, all individualised goals of care were summarised, which were subsequently used to assess whether life history questionnaires had supplied sufficient information to define various individualised goals of care. We then conducted semi-structured interviews with the involved healthcare professionals to gain insights on how these questionnaires were used. Results: Approximately one-third of all individualised goals of care belonging to the “Activities and Participation” ICF category were defined through life history questionnaires. The semi-structured interviews highlighted the impact of these questionnaires in three main aspects: creating a therapeutic alliance with the patient, facilitating multidisciplinary cohesion, and nurturing a sense of empathy amongst the healthcare professionals. Conclusions: Life history questionnaires are an important contribution to individualised goals of care and may improve the relationship with the patient and the therapeutic setting for all healthcare professionals involved.