Sorghum is a nutritious, healthy, gluten-free whole grain, with the United States (U.S.) leading its production globally. While sorghum is consumed worldwide, it is mainly used for animal feed and biofuel in the U.S. Organoleptic characteristics and consumers’ perceptions determine food acceptance and eating behavior. Therefore, this study aimed to investigate the acceptance of and eating and purchase intentions toward sorghum-based foods among college students in a southern university in the U.S. Eighty-three students participated in a series of sensory evaluations using two sets of four sorghum samples each and a 15 min break. Seven sensory attributes were evaluated with a nine-point hedonic scale, and a five-point scale was used for eating and purchase intentions. To assess the panelists’ acceptance, the overall acceptance scale score (range: 1–9) was normalized (range: 0–100) and used for analyses. Spiced sorghum cookies (77.95 ± 14.23) had the highest acceptance, followed by sorghum shrimp grits (74.51 ± 19.42). Overall acceptance, eating intention, and purchase intention were strongly associated across all food items, although the strength differed by food type. Sorghum-based foods were accepted despite the participants’ lack of exposure to sorghum and its null consumption. These outcomes will help to develop innovative sorghum-based foods to facilitate sorghum consumption and benefit consumer health in the U.S.