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Lead (Pb2+) pollution is a serious food safety issue, rapid detection of Pb2+ residual in food is vital to guarantee food quality and safety. Here we proposed ratiometric aptamer probes, allowing robust Pb2+ supervision in food samples. Pb2+ specific aptamer can bolster a transition of G-quadruplex structural response to Pb2+; this process can be monitored by N-methyl mesoporphyrin IX (NMM), which is highly specific to G-quadruplex. Particularly, the utilization of G-quadruplex specific dye and terminal-labeled fluorophore allowed to endue ratiometric signal outputs towards Pb2+, dramatically increase the robustness for lead detection. The ratiometric G-quadruplex assay allowed a facile and one-pot Pb2+ detection at room temperature using a single-stranded DNA aptamer. We demonstrated its feasibility for detecting lead pollution in fresh eggs and tap water samples. The ratiometric G-quadruplex design is expected to be used for on-site Pb2+ testing associated with food safety.
Yumei Liu; Hao Yang; Rui Wan; Mohammad Rizwan Khan; Nan Wang; Rosa Busquets; Ruijie Deng; Qiang He; Zhifeng Zhao. Ratiometric G-Quadruplex Assay for Robust Lead Detection in Food Samples. Biosensors 2021, 11, 274 .
AMA StyleYumei Liu, Hao Yang, Rui Wan, Mohammad Rizwan Khan, Nan Wang, Rosa Busquets, Ruijie Deng, Qiang He, Zhifeng Zhao. Ratiometric G-Quadruplex Assay for Robust Lead Detection in Food Samples. Biosensors. 2021; 11 (8):274.
Chicago/Turabian StyleYumei Liu; Hao Yang; Rui Wan; Mohammad Rizwan Khan; Nan Wang; Rosa Busquets; Ruijie Deng; Qiang He; Zhifeng Zhao. 2021. "Ratiometric G-Quadruplex Assay for Robust Lead Detection in Food Samples." Biosensors 11, no. 8: 274.
The aim of the research was to prepare low-cost adsorbents, including raw date pits and chemically treated date pits, and to apply these materials to investigate the adsorption behavior of Cr(III) and Cd(II) ions from wastewater. The prepared materials were characterized using SEM, FT-IR and BET surface analysis techniques for investigating the surface morphology, particle size, pore size and surface functionalities of the materials. A series of adsorption processes was conducted in a batch system and optimized by investigating various parameters such as solution pH, contact time, initial metal concentrations and adsorbent dosage. The optimum pH for achieving maximum adsorption capacity was found to be approximately 7.8. The determination of metal ions was conducted using atomic adsorption spectrometry. The experimental results were fitted using isotherm Langmuir and Freundlich equations, and maximum monolayer adsorption capacities for Cr(III) and Cd(II) at 323 K were 1428.5 and 1302.0 mg/g (treated majdool date pits adsorbent) and 1228.5 and 1182.0 mg/g (treated sagai date pits adsorbent), respectively. It was found that the adsorption capacity of H2O2-treated date pits was higher than that of untreated DP. Recovery studies showed maximal metal elution with 0.1 M HCl for all the adsorbents. An 83.3–88.2% and 81.8–86.8% drop in Cr(III) and Cd(II) adsorption, respectively, were found after the five regeneration cycles. The results showed that the Langmuir model gave slightly better results than the Freundlich model for the untreated and treated date pits. Hence, the results demonstrated that the prepared materials could be a low-cost and eco-friendly choice for the remediation of Cr(III) and Cd(II) contaminants from an aqueous solution.
Mohammad Azam; Saikh Wabaidur; Mohammad Khan; Saud Al-Resayes; Mohammad Islam. Removal of Chromium(III) and Cadmium(II) Heavy Metal Ions from Aqueous Solutions Using Treated Date Seeds: An Eco-Friendly Method. Molecules 2021, 26, 3718 .
AMA StyleMohammad Azam, Saikh Wabaidur, Mohammad Khan, Saud Al-Resayes, Mohammad Islam. Removal of Chromium(III) and Cadmium(II) Heavy Metal Ions from Aqueous Solutions Using Treated Date Seeds: An Eco-Friendly Method. Molecules. 2021; 26 (12):3718.
Chicago/Turabian StyleMohammad Azam; Saikh Wabaidur; Mohammad Khan; Saud Al-Resayes; Mohammad Islam. 2021. "Removal of Chromium(III) and Cadmium(II) Heavy Metal Ions from Aqueous Solutions Using Treated Date Seeds: An Eco-Friendly Method." Molecules 26, no. 12: 3718.
In the present work, the amounts of bisphenol A (BPA) were determined in ninety-three commercially available fruit juice (S1-S93) packed in different type of bottles made from polyethylene terephthalate (PET), multi-layer paper/plastic/aluminium (multi-layer PPA) and glass packaging materials. The BPA identification was performed by solid-phase extraction (SPE) and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). BPA was identified in ∼83 % of the juice samples at concentrations ranged from 0.14–28.97 μg/L. PET bottled juice contained higher amounts of BPA (0.57–28.97 μg/L) than the juice packed in multi-layer PPA (not detected-5.48 μg/L) and glass (not detected-0.43 μg/L) packaging materials. The outcomes revealed that the variation of BPA concentrations in fruit juice is depend on the types of packaging materials. The dietary consumption of BPA was found to be 0.015 μg/kg bw/day, which is based on the achieved average BPA concentrations (4.37 μg/L). The obtained BPA exposure through the consumption of fruit juice was found to be lower than the threshold values (50 μg/L) set by the regulatory agencies. The results also demonstrated that fruit juice is a substantial dietary source of BPA and can be applied in epidemiological research to estimate the exposure of BPA from dietary surveys.
Mohammad Rizwan Khan; Mohamed Ouladsmane; Ahmad Moid Alammari; Mohammad Azam. Bisphenol A leaches from packaging to fruit juice commercially available in markets. Food Packaging and Shelf Life 2021, 28, 100678 .
AMA StyleMohammad Rizwan Khan, Mohamed Ouladsmane, Ahmad Moid Alammari, Mohammad Azam. Bisphenol A leaches from packaging to fruit juice commercially available in markets. Food Packaging and Shelf Life. 2021; 28 ():100678.
Chicago/Turabian StyleMohammad Rizwan Khan; Mohamed Ouladsmane; Ahmad Moid Alammari; Mohammad Azam. 2021. "Bisphenol A leaches from packaging to fruit juice commercially available in markets." Food Packaging and Shelf Life 28, no. : 100678.
Heavy metals are the harmful elements, regarded as carcinogens. Nevertheless, owing to their physical and chemical properties, they are still used in the production of several commercial products. Utilization of such products increases the chance for the exposure of heavy metals, some of them are categorized as probable human carcinogens (Group 1) by the International Agency for Research on Cancer. Exposure of heavy metals to school children at early age can result severe life time health issues and high chance of emerging cancer. Thus, we have performed study relating to the presence of heavy metals in acrylic color paints commonly used by the school children. Acrylic paints of different colors were assayed for seven potential heavy metals manganese (Mn), cobalt (Co), nickel (Ni), zinc (Zn), arsenic (As), cadmium (Cd) and lead (Pb) using microwave digestion and iCAPQ inductively coupled plasma mass spectrometry (ICP-MS) system. The optimized method including paints digestion reagents nitric acid (HNO3, 65%, 5 mL) and hydrofluoric acid (HF, 40%, 2 mL) have offered excellent method performance with recovery values ranged between 99.33% and 105.67%. The elements were identified in all of the analyzed samples with concentrations ranged from 0.05 to 372.59 µg/g. Cd constitutes the lower percentage (0.05%), whereas Zn constitutes high ratio contribution which was tremendously high (68.33%). Besides, the paints contamination was also color specific, with considerably total heavy metal concentrations found in brunt umber (526.57 µg/g) while scarlet color (12.62 µg/g) contained lower amounts. The outcomes of our investigation highlight the necessity for guidelines addressing the heavy metals in acrylic color paints intended for the school children usage.
Mohammad Khan; Naushad Ahmad; Mohamed Ouladsmane; Mohammad Azam. Heavy Metals in Acrylic Color Paints Intended for the School Children Use: A Potential Threat to the Children of Early Age. Molecules 2021, 26, 2375 .
AMA StyleMohammad Khan, Naushad Ahmad, Mohamed Ouladsmane, Mohammad Azam. Heavy Metals in Acrylic Color Paints Intended for the School Children Use: A Potential Threat to the Children of Early Age. Molecules. 2021; 26 (8):2375.
Chicago/Turabian StyleMohammad Khan; Naushad Ahmad; Mohamed Ouladsmane; Mohammad Azam. 2021. "Heavy Metals in Acrylic Color Paints Intended for the School Children Use: A Potential Threat to the Children of Early Age." Molecules 26, no. 8: 2375.
In the current study, an analytical technique has been optimized for the analysis of disinfection by-products (perchlorate (ClO4−), bromate (BrO3−), nitrate (NO3−), nitrite and sulfite (SO32–) in drinking water obtained from spring, well and tap water (desalinated) sources. The ultra-performance liquid chromatography-electrospray ionization mass spectrometry (UPLC-ESI/MS) conditions have been optimized for oxyhalides ClO4− (isotopes, 37ClO4− and 35ClO4−) and BrO3− (isotopes, 81BrO3− and 79BrO3−), and inorganic anions NO3−, NO2− and SO32–. Separation was achieved by BEH C18 column with methanol (75%) and water (24.99%, HCOOH 0.01%) mobile phase at flow rate 0.2 mL/min. The analysis was carried out in 0.995–0.999), limit of detection (0.016–0.043 µg/L), limit of quantification (0.051–0.104 µg/L) and precision (repeatability, 1.54–2.28% and reproducibility, 3.13–4.08%) in terms of RSD%. The method was successfully applied, and the amounts of 35ClO4− (5.33–22.64 µg/L), 81BrO3− (7.52–16.73 µg/L), NO3− (5.42–12.14 mg/L), NO2− (1.08–4.37 mg/L) and SO32– (6.84–32.45 mg/L) were identified in spring water, whereas well and tap water contained 35ClO4− (4.20–21.33 µg/L), 81BrO3− (8.05–15.13 µg/L), NO3− (1.27–16.11 mg/L), NO2− (0.43–10.77 mg/L) and SO32– (7.14–36.10 mg/L), and 35ClO4− (0.89–7.37 µg/L), 81BrO3− (5.15–14.68 µg/L), NO3− (1.12–6.33 mg/L), NO2− (0.67–3.95 mg/L) and SO32– (5.40–23.26 mg/L), respectively. The levels of 35ClO4−, 81BrO3−, NO3−, NO2− and SO32– were found beyond the maximum contaminant levels and drinking water equivalent levels regulated by the Environmental Protection Agency, respectively. The outcomes also revealed that comparatively tap water produced lower levels of these contaminants especially in the cities with low population densities. In addition, the geographical site would be helpful to categorize the tap water samples.
Mohammad Rizwan Khan; Mohammad Shahzad Samdani; Mohammad Azam; Mohamed Ouladsmane. UPLC-ESI/MS analysis of disinfection by-products (perchlorate, bromate, nitrate, nitrite and sulfite) in micro-filtered drinking water obtained from spring, well and tap water (desalinated) sources. Journal of King Saud University - Science 2021, 33, 101408 .
AMA StyleMohammad Rizwan Khan, Mohammad Shahzad Samdani, Mohammad Azam, Mohamed Ouladsmane. UPLC-ESI/MS analysis of disinfection by-products (perchlorate, bromate, nitrate, nitrite and sulfite) in micro-filtered drinking water obtained from spring, well and tap water (desalinated) sources. Journal of King Saud University - Science. 2021; 33 (4):101408.
Chicago/Turabian StyleMohammad Rizwan Khan; Mohammad Shahzad Samdani; Mohammad Azam; Mohamed Ouladsmane. 2021. "UPLC-ESI/MS analysis of disinfection by-products (perchlorate, bromate, nitrate, nitrite and sulfite) in micro-filtered drinking water obtained from spring, well and tap water (desalinated) sources." Journal of King Saud University - Science 33, no. 4: 101408.
Ammonia electro-oxidation (AEO) is a zero carbon-emitting sustainable means for the generation of hydrogen fuel, but its commercialization is deterred due to sluggish reaction kinetics and the poisoning of expensive metal electrocatalysts. With this perspective, CuO impregnated γ-Al2O3 (CuO/γ-Al2O3) hybrid materials were synthesized as effective and affordable electrocatalysts and investigated for AEO in alkaline media. Structural investigations were performed via different characterization techniques, i.e., X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electrochemical impedance spectroscopy (EIS). The morphology of γ-Al2O3 support as interconnected porous structures rendered the CuO/γ-Al2O3 nanocatalysts with robust activity. The additional CuO impregnation resulted in the enhanced electrochemical active surface area (ECSAs) and diffusion coefficient and spiked the electrocatalytic performance for NH3 electrolysis. Owing to good values of diffusion coefficient for AEO, low bandgap, and availability of ample ECSA at higher CuO to γ-Al2O3 ratio, these proposed electrocatalysts were proved to be effective in AEO. Due to good reproducibility, electrochemical stability, and higher activity for ammonia electro-oxidation, CuO/γ-Al2O3 nanomaterials are proposed as efficient promoters, electrode materials, or catalysts in ammonia electrocatalysis.
Safia Khan; Syed Shah; Mohsin Anjum; Mohammad Khan; Naveed Janjua. Electro-Oxidation of Ammonia over Copper Oxide Impregnated γ-Al2O3 Nanocatalysts. Coatings 2021, 11, 313 .
AMA StyleSafia Khan, Syed Shah, Mohsin Anjum, Mohammad Khan, Naveed Janjua. Electro-Oxidation of Ammonia over Copper Oxide Impregnated γ-Al2O3 Nanocatalysts. Coatings. 2021; 11 (3):313.
Chicago/Turabian StyleSafia Khan; Syed Shah; Mohsin Anjum; Mohammad Khan; Naveed Janjua. 2021. "Electro-Oxidation of Ammonia over Copper Oxide Impregnated γ-Al2O3 Nanocatalysts." Coatings 11, no. 3: 313.
Bisphenol A (BPA) is a hazardous contaminant demonstrating endocrine disrupting properties, and assumed to be involved in the pathogenesis of various cancer diseases for instance prostate, lung and breast cancer. The objective of the present study was to estimate the BPA amounts in carbonated beverages from the Saudi Arabian market for the first time using an authenticated technique based on solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. A total of thirty-four carbonated beverages of different flavors, origin and packaging materials were studied. The beverage production periods were from February 2018 to July 2018 containing volume (250-1000 mL), packaging materials were of canned, glass and polyethylene terephthalate (PET) plastic. BPA amounts in canned (0.64-11.41 µg/L), glass bottled (1.92-29.56 µg/L) and PET plastic bottled (0.37-21.83 µg/L) were obtained with recovery (97.64-99.96%). Relatively, glass bottled has offered higher amounts of BPA compared to PET plastic bottled and canned samples. The unforeseen presence of BPA especially in glass bottled emphasizes the ubiquity of such compound beside the food fabrication chain, far off to the food packaging materials. Thus, a further knowledge on BPA amounts in glass bottled samples, in addition to threat assessment studies, is essential to defend human health.
Mohammad Rizwan Khan; Ahmad Moid Alammari; Ahmad Aqel; Mohammad Azam. Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin. Food Science and Technology 2021, 41, 210 -217.
AMA StyleMohammad Rizwan Khan, Ahmad Moid Alammari, Ahmad Aqel, Mohammad Azam. Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin. Food Science and Technology. 2021; 41 (1):210-217.
Chicago/Turabian StyleMohammad Rizwan Khan; Ahmad Moid Alammari; Ahmad Aqel; Mohammad Azam. 2021. "Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin." Food Science and Technology 41, no. 1: 210-217.
Benthic microbial fuel cells (BMFCs) are considered to be one of the eco-friendly bioelectrochemical cell approaches nowadays. The utilization of waste materials in BMFCs is to generate energy and concurrently bioremediate the toxic metals from synthetic wastewater, which is an ideal approach. The use of novel electrode material and natural organic waste material as substrates can minimize the present challenges of the BMFCs. The present study is focused on cellulosic derived graphene-polyaniline (GO-PANI) composite anode fabrication in order to improve the electron transfer rate. Several electrochemical and physicochemical techniques are used to characterize the performance of anodes in BMFCs. The maximum current density during polarization behavior was found to be 87.71 mA/m2 in the presence of the GO-PANI anode with sweet potato as an organic substrate in BMFCs, while the GO-PANI offered 15.13 mA/m2 current density under the close circuit conditions in the presence of 1000 Ω external resistance. The modified graphene anode showed four times higher performance than the unmodified anode. Similarly, the remediation efficiency of GO-PANI was 65.51% for Cd (II) and 60.33% for Pb (II), which is also higher than the unmodified graphene anode. Furthermore, multiple parameters (pH, temperature, organic substrate) were optimized to validate the efficiency of the fabricated anode in different environmental atmospheres via BMFCs. In order to ensure the practice of BMFCs at industrial level, some present challenges and future perspectives are also considered briefly.
Asim Ali Yaqoob; Mohamad Nasir Mohamad Ibrahim; Khalid Umar; Showkat Ahmad Bhawani; Anish Khan; Abdullah M. Asiri; Mohammad Rizwan Khan; Mohammad Azam; Ahmad Moid AlAmmari. Cellulose Derived Graphene/Polyaniline Nanocomposite Anode for Energy Generation and Bioremediation of Toxic Metals via Benthic Microbial Fuel Cells. Polymers 2020, 13, 135 .
AMA StyleAsim Ali Yaqoob, Mohamad Nasir Mohamad Ibrahim, Khalid Umar, Showkat Ahmad Bhawani, Anish Khan, Abdullah M. Asiri, Mohammad Rizwan Khan, Mohammad Azam, Ahmad Moid AlAmmari. Cellulose Derived Graphene/Polyaniline Nanocomposite Anode for Energy Generation and Bioremediation of Toxic Metals via Benthic Microbial Fuel Cells. Polymers. 2020; 13 (1):135.
Chicago/Turabian StyleAsim Ali Yaqoob; Mohamad Nasir Mohamad Ibrahim; Khalid Umar; Showkat Ahmad Bhawani; Anish Khan; Abdullah M. Asiri; Mohammad Rizwan Khan; Mohammad Azam; Ahmad Moid AlAmmari. 2020. "Cellulose Derived Graphene/Polyaniline Nanocomposite Anode for Energy Generation and Bioremediation of Toxic Metals via Benthic Microbial Fuel Cells." Polymers 13, no. 1: 135.
In the present work, fifteen mutagenic/carcinogenic heterocyclic amines (HAs) were studied in cooked Caridean shrimp (pink) and Penaeid shrimp (tiger, white and brown). The cooking methods were used as stir-frying, broiling and steaming under controlled temperature and time, and HAs determination was performed by SPE/UPLC-ESI-MS/MS. HAs 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-1,6-dimethyl-imidazo[4,5-b]pyridine (DMIP), 1-Methyl-9H-pyrido[3,4-b]indole (Harman) and 9H-pyrido[3,4-b]indole (Norharman) were identified (0.05–22.48 ng/g) in all stir-fried and broiled shrimp, whereas 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) was only found (0.08–0.35 ng/g) in stir-fried shrimp. HAs 2-Amino-3,7,8-trimethyl-imidazo[4,5-f]quinoxaline (7,8-DiMeIQx) and, α-carbolines 2-Amino-9H-pyrido[2,3-b]indole (AαC) and 2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC), γ-carbolines 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-Amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and δ-carbolines 2-Amino-6-methyldipyrido[1,2-α:3́,2́-d]imidazole (Glu-P-1) and 2-Aminodipyrido[1,2-α:3́,2́-d]imidazole (Glu-P-2) were not detected or found below quantification limit. Brown shrimp (stir-fried) appeared to be more contaminated which constitutes total HAs (81.93 ng/g) followed by pink (70.41 ng/g), tiger (53.02 ng/g) and white (33.57 ng/g). Steaming method does not yield any HAs, and the cause might be elucidate that shrimp were not directly in contact with cooking pan or fire which affect the HAs formation. Food precursors (protein, moisture, fat, creatine and glucose) were also measured in raw and cooked shrimp to investigate the influence on HAs formation. Creatine (3.85 mg/g) and glucose (0.43 mg/g) were found at higher concentrations in brown shrimp, generates high amounts of HAs. Our findings have illustrated that the cooking method, shrimp types and precursors are the main contributors to the formation of HAs. The outcomes from this work could be applied to estimate the HAs human intake globally and add to steaming cooking method in such types of food products that diminish the risk of HAs exposure, and thus to get healthier food quality and security.
Mohammad Rizwan Khan; Mohammad Azam. Shrimp as a substantial source of carcinogenic heterocyclic amines. Food Research International 2020, 140, 109977 .
AMA StyleMohammad Rizwan Khan, Mohammad Azam. Shrimp as a substantial source of carcinogenic heterocyclic amines. Food Research International. 2020; 140 ():109977.
Chicago/Turabian StyleMohammad Rizwan Khan; Mohammad Azam. 2020. "Shrimp as a substantial source of carcinogenic heterocyclic amines." Food Research International 140, no. : 109977.
In the present study, a rapid, sensitive and selective method has been optimized for the quantification of perchlorate (ClO4−) in drinking water treated with ozonation and chlorination disinfection processes. An analytical technique based on ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) has been optimized for the determination of perchlorate in drinking water. Prior to the analysis, the filtered water samples were directly injected into the system without any sample pretreatment. The ClO4− was quantified by examining the high intensity ion signal (m/z 83), produced by a removal of an oxygen atom from the ClO4− parent ion. The performance of the method was established, achieving excellent values for instance linearity (R2=0.9999), limit of detection (0.009 µg/L), limit of quantification (0.030 µg/L), precisions (run-to-run, 1.56% and day-to-day, 2.15%) in terms of relative standard deviation while examining a standard of ClO4− (5 µg/L). The elution time of ClO4− was found to be 0.51 min at 300 µL/min flow rate. A total of forty-five water samples were studied, obtaining the ClO4− concentrations in bottled and metropolitan water ranging from 0.78 to 53.23 µg/L and 0.18 to 2.62 µg/L, respectively. The metropolitan water was found to be least contaminated than the bottled water, and found to be lower than the Reference Dose (RfD) value 0.007 mg/kg body weight/day and Drinking Water Equivalent Level (DWEL) value 25 µg/L set by the US Environmental Protection Agency. Furthermore, in comparison to the traditional methods, the proposed technique was found to be very efficient, cost-effective and rapid for the routine determination of ClO4− at trace level in water samples.
Mohammad Rizwan Khan; Mohammad Azam; Ahmad Moid Alammari. Ultra-performance liquid chromatography/tandem mass spectrometry for the trace-level identification of perchlorate in filtered drinking water treated with ozonation and chlorination disinfection processes. Journal of King Saud University - Science 2020, 33, 101267 .
AMA StyleMohammad Rizwan Khan, Mohammad Azam, Ahmad Moid Alammari. Ultra-performance liquid chromatography/tandem mass spectrometry for the trace-level identification of perchlorate in filtered drinking water treated with ozonation and chlorination disinfection processes. Journal of King Saud University - Science. 2020; 33 (1):101267.
Chicago/Turabian StyleMohammad Rizwan Khan; Mohammad Azam; Ahmad Moid Alammari. 2020. "Ultra-performance liquid chromatography/tandem mass spectrometry for the trace-level identification of perchlorate in filtered drinking water treated with ozonation and chlorination disinfection processes." Journal of King Saud University - Science 33, no. 1: 101267.
Herein, the interaction of the fourth-generation fluoroquinolone antibiotic drug, moxifloxacin hydrochloride (MFH), which is extensively used for the treatment of wider ranges of bacterial infections, like pneumonia, endocarditis, tuberculosis, and other complicated dermal lesions, and cetyltrimethylammonium bromide (CTAB, a cationic surfactant) has been observed by conductivity method in aqueous, alcoholic (C2H5OH, C3H7OH-2), and diol (C2H4(OH)2, C3H6(OH)2) solutions. For all of the MFH + CTAB cases studied, the appearance of a critical micelle concentration (cmc) demonstrated that the micellar system is dependent on the variation of temperature and the concentration of different additives. A change in the value of cmc manifests the existence of strong interaction prevailing amongst MFH and CTAB molecules. In presence of alcohols/diols, the value of cmc for the MFH + CTAB system was found higher compared to those values obtained for the MFH + CTAB system carried out in H2O, which indicates a favourable micellization process. The values of counter-ion dissociation were also found to be dependent on temperature. The Δ G m o values were observed negative, which, again, manifests a spontaneous micellization process. The free energy of transfer ( Δ G m , t r o ) and the enthalpy–entropy compensation were also calculated and discussed. GRAPHICAL ABSTRACT
Miah Muhammed Muktadir Rashid; Marzia Rahman; Mohammad Majibur Rahman; Shamim Mahbub; Dileep Kumar; Mohammad Rizwan Khan; Zeid A. Alothman; Anamul Hoque. Aggregation, interaction and thermodynamic characteristics of cationic surfactant + moxifloxacin hydrochloride mixture in aquatic solutions of mono-/di-hydroxy compounds. Molecular Physics 2020, 119, e1849839 .
AMA StyleMiah Muhammed Muktadir Rashid, Marzia Rahman, Mohammad Majibur Rahman, Shamim Mahbub, Dileep Kumar, Mohammad Rizwan Khan, Zeid A. Alothman, Anamul Hoque. Aggregation, interaction and thermodynamic characteristics of cationic surfactant + moxifloxacin hydrochloride mixture in aquatic solutions of mono-/di-hydroxy compounds. Molecular Physics. 2020; 119 (6):e1849839.
Chicago/Turabian StyleMiah Muhammed Muktadir Rashid; Marzia Rahman; Mohammad Majibur Rahman; Shamim Mahbub; Dileep Kumar; Mohammad Rizwan Khan; Zeid A. Alothman; Anamul Hoque. 2020. "Aggregation, interaction and thermodynamic characteristics of cationic surfactant + moxifloxacin hydrochloride mixture in aquatic solutions of mono-/di-hydroxy compounds." Molecular Physics 119, no. 6: e1849839.
Isothiazolinones methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI), and parabens methylparaben (MP), ethylparaben (EP), propylparaben (PP) and butylparaben (BP) are the most common synthetic preservatives. They are all known to be potential skin allergens that lead to contact dermatitis. Thus, the identification of these unsafe chemicals in cosmetic products is of high importance. In the present study, solid-phase extraction (SPE) based on HyperSep reversed-phase C8/benzene sulfonic acid ion exchanger (HyperSep C8/BSAIE) and Sep-Pak C18 sorbents, and ultra-high performance liquid chromatography/diode array detector (UHPLC/DAD) were optimized for the simultaneous determination of MI, MCI, MP, EP, PP and BP in cosmetic products. HyperSep C8/BSAIE and UHPLC/DAD with the eluting solvent mixture (acetonitrile/methanol, 2:1, v/v) and detection wavelength (255 nm) were found to be the optimal conditions, respectively. The method illustrates the excellent linearity range (0.008–20 μg/mL) with coefficient of determination (R2, 0.997–0.999), limits of detection (LOD, 0.001–0.002 μg/mL), precision in terms of relative standard deviation (RSD < 3%, intra-day and
Hazim Mohammed Ali; Ibrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Mohammad Azam. Simultaneous Determination of Isothiazolinones and Parabens in Cosmetic Products Using Solid-Phase Extraction and Ultra-High Performance Liquid Chromatography/Diode Array Detector. Pharmaceuticals 2020, 13, 412 .
AMA StyleHazim Mohammed Ali, Ibrahim Hotan Alsohaimi, Mohammad Rizwan Khan, Mohammad Azam. Simultaneous Determination of Isothiazolinones and Parabens in Cosmetic Products Using Solid-Phase Extraction and Ultra-High Performance Liquid Chromatography/Diode Array Detector. Pharmaceuticals. 2020; 13 (11):412.
Chicago/Turabian StyleHazim Mohammed Ali; Ibrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Mohammad Azam. 2020. "Simultaneous Determination of Isothiazolinones and Parabens in Cosmetic Products Using Solid-Phase Extraction and Ultra-High Performance Liquid Chromatography/Diode Array Detector." Pharmaceuticals 13, no. 11: 412.
The newly synthesized dinuclear uranyl salen coordination compound showed excellent photocatalytic reduction of CO2 to methanol.
Mohammad Azam; Umesh Kumar; Joshua O. Olowoyo; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Mohammadd Shahidul Islam; Mohammad Rizwan Khan; Syed Farooq Adil; Mohammad Rafique Siddiqui; Fahad Ahmed Al-Harthi; Abdul Karim Alinzi; Saikh Mohammad Wabaidur; Masoom Raza Siddiqui; Mohammed Rafi Shaik; Suman L. Jain; M. Amin Farkhondehfal; Simelys Hernàndez. Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol. Dalton Transactions 2020, 49, 17243 -17251.
AMA StyleMohammad Azam, Umesh Kumar, Joshua O. Olowoyo, Saud I. Al-Resayes, Agata Trzesowska-Kruszynska, Rafal Kruszynski, Mohammadd Shahidul Islam, Mohammad Rizwan Khan, Syed Farooq Adil, Mohammad Rafique Siddiqui, Fahad Ahmed Al-Harthi, Abdul Karim Alinzi, Saikh Mohammad Wabaidur, Masoom Raza Siddiqui, Mohammed Rafi Shaik, Suman L. Jain, M. Amin Farkhondehfal, Simelys Hernàndez. Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol. Dalton Transactions. 2020; 49 (47):17243-17251.
Chicago/Turabian StyleMohammad Azam; Umesh Kumar; Joshua O. Olowoyo; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Mohammadd Shahidul Islam; Mohammad Rizwan Khan; Syed Farooq Adil; Mohammad Rafique Siddiqui; Fahad Ahmed Al-Harthi; Abdul Karim Alinzi; Saikh Mohammad Wabaidur; Masoom Raza Siddiqui; Mohammed Rafi Shaik; Suman L. Jain; M. Amin Farkhondehfal; Simelys Hernàndez. 2020. "Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol." Dalton Transactions 49, no. 47: 17243-17251.
Bladder cancer is one of the deadly cancer with 16,390 deaths in 2015-16 alone and 76,960 new cases. The matter of concern is more severe with very limited options of treatment and lack of new drugs, cisplatin and doxorubicin are the only two drugs mostly used in therapy. This situation along with the epidemiological data calls for the development of newer better and safer agents. Herein, we report nine novel benzothiazole derivatives based on structure-based drug discovery and molecular modelling approaches. Newly designed compounds were synthesized following a four-step reaction and were characterized for structural confirmation. These novel compounds were evaluated on the MTT assay for their in vitro efficiency using the TCP1020 cell lines. These were further analysed for their mechanism of action based on in silico studies. Two compounds of the series exhibit promising results which are in agreement with the in-silico studies. It was found that the methyl group at the seventh position to the nitrogen decreases the electron affinity of the series and is thus responsible for the activity in 4e. The methyl substituted compound 4e and fluoro substituted compound 4i shows the highest activities with an IC50 of 10.1 ± 0.2 and 7.8 ± 0.7 respectively.
Purushottam Kapse; Rupesh V. Chikhale; Mohammad Rizwan Khan; Saikh M. Wabaidur; Ataul Islam. Synthesis of novel cycloheptylbenzothiazole-2-carboxamides and biological evaluation as human estrogen receptor modulators. Journal of Molecular Structure 2020, 1227, 129516 .
AMA StylePurushottam Kapse, Rupesh V. Chikhale, Mohammad Rizwan Khan, Saikh M. Wabaidur, Ataul Islam. Synthesis of novel cycloheptylbenzothiazole-2-carboxamides and biological evaluation as human estrogen receptor modulators. Journal of Molecular Structure. 2020; 1227 ():129516.
Chicago/Turabian StylePurushottam Kapse; Rupesh V. Chikhale; Mohammad Rizwan Khan; Saikh M. Wabaidur; Ataul Islam. 2020. "Synthesis of novel cycloheptylbenzothiazole-2-carboxamides and biological evaluation as human estrogen receptor modulators." Journal of Molecular Structure 1227, no. : 129516.
In the present work, a method based on solvent extraction and gas chromatography–mass spectrometry (GC-MS) has been validated for the determination of 1,4-dioxane in cosmetics. Various solvents including ethyl acetate, hexane, methanol, dichloromethane and acetone have been used for the extraction of 1,4-dioxane, among them the ethyl acetate was found to be the most efficient extracting solvent. This method has offered excellent quality parameters for instance linearity (R 2 > 0.9991), limit of detection (LOD, 0.00065-0.00091 µg/mL), limit of quantification (LOQ, 0.00217–0.00304 µg/mL) and, precision intra-day (1.65–2.60%, n = 5) and inter-day (0.16–0.32%, n = 5) in terms of relative standard deviation (RSD%). A total of thirty-nine cosmetic samples of different brands and origin have been studied. Among them, the 1,4-dioxane was found in twenty-three samples (FB1-FB7, MC1-MC4, MC6-MC8, HS3, HS5, BL1-BL3, BL5 and PLD1-PLD3) at the levels between 0.15 µg/mL and 9.92 µg/mL, whereas in sixteen samples (MC5, HS1, HS2, SG1-SG5, BL4 and HP1- HP6) was found to be not detected. The recovery values were achieved between 93% and 99% in both low and high level of spiked samples. In comparison to the traditional analytical techniques, the proposed method was found to be very sensitive and cost-effective for the routine analysis of 1,4-dioxane at low concentration in cosmetics.
Ibrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Hazim Ali; Mohammad Azam; Ahmed Moid Alammari. Solvent extraction and gas chromatography–mass spectrometric determination of probable carcinogen 1,4-dioxane in cosmetic products. Scientific Reports 2020, 10, 1 -9.
AMA StyleIbrahim Hotan Alsohaimi, Mohammad Rizwan Khan, Hazim Ali, Mohammad Azam, Ahmed Moid Alammari. Solvent extraction and gas chromatography–mass spectrometric determination of probable carcinogen 1,4-dioxane in cosmetic products. Scientific Reports. 2020; 10 (1):1-9.
Chicago/Turabian StyleIbrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Hazim Ali; Mohammad Azam; Ahmed Moid Alammari. 2020. "Solvent extraction and gas chromatography–mass spectrometric determination of probable carcinogen 1,4-dioxane in cosmetic products." Scientific Reports 10, no. 1: 1-9.
Sulfite ion play a crucial role in the atmospheric environment, its presence in water system is very unsafe to both the human and food production due to the formation of acid after reaction with water (acid rain). In the current investigation, ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method was used for the identification and quantification of sulfite ion in drinking water and the process was optimized. In this study, a reversed phase BEH C18 chromatography column was applied for the separation of sulfite ion using binary mobile phase comprising water and methanol (95:5, v/v), separation was attained in less than 1 min. Method validation parameters in terms of linearity (r2), limit of detection (LOD), limit of quantification (LOQ) and precision were established. The linearity (r2 > 0.999) and, LOD and LOQ were obtained 0.003 µg/mL and 0.01 µg/mL respectively. The precision in terms of relative standard deviation (RSD) was found to be < 3.5%. The validated standard methodology was used for the quantitative determination of sulfite ion in water obtained from different sources. The sulfite ion amounts were found between 2.21 µg/mL and 90.11 µg/mL water sample, and the recovery values were obtained between 97.55% and 104.49%. It was observed from the data that the quantified levels of sulfite ion were above the maximum contaminant levels (MCLs, 10 μg/mL) according to US Environmental Protection Agency in all 100% metropolitan water samples and about 82% of the analyzed bottled waters. In addition, the comparison of results obtained in water samples from Saudi Arabia with formerly stated data were carried out. The benefits of applying UPLC-MS as a new method in competition with other techniques are smaller analysis time (<1 min), tremendous accuracy and higher recovery values. Nonetheless, the sulfite was still detected in drinking water samples from Saudi Arabia. Hence, the detecting and decreasing the level of sulfite in water samples needed further apprehensions to meet better needs of strategies for consumer health.
Mohammad Rizwan Khan; Saikh Mohammad Wabaidur; Mohammad Azam; Ahmad Moid AlAmmari. Assessment of inorganic ion in drinking water using new method based on ultra-performance liquid chromatography-mass spectrometry. Journal of King Saud University - Science 2020, 32, 2329 -2335.
AMA StyleMohammad Rizwan Khan, Saikh Mohammad Wabaidur, Mohammad Azam, Ahmad Moid AlAmmari. Assessment of inorganic ion in drinking water using new method based on ultra-performance liquid chromatography-mass spectrometry. Journal of King Saud University - Science. 2020; 32 (4):2329-2335.
Chicago/Turabian StyleMohammad Rizwan Khan; Saikh Mohammad Wabaidur; Mohammad Azam; Ahmad Moid AlAmmari. 2020. "Assessment of inorganic ion in drinking water using new method based on ultra-performance liquid chromatography-mass spectrometry." Journal of King Saud University - Science 32, no. 4: 2329-2335.
Water quality especially drinking water is highly significant to human lives. To access the safe and secure drinking water, nowadays it has become an issue of global concerns. A novel method using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was proposed to analyze sulfate level in bottled and metropolitan water collected from various provinces of Saudi Arabia. The chromatographic analysis was achieved within 1 min with reversed phase Waters Acquity® BEH C18 column and a triple quadrupole mass spectrometer. The performance of the optimized system was established, attaining linearity (r2>0.999) over a wide-ranging concentration from several below hundred mg/L to the detection limit of sulfate. In terms of relative standard deviation of the samples (RSD%), the excellent run-to-run (<2%, n = 5) and day-to-day (<4%, n = 5) precisions were achieved when examining a sulfate standard (0.01 mg/L) and non-spiked bottled water sample with the concentration of sulfate (4.76mg/L). The developed method is helpful to identify sulfate in bottled and metropolitan water samples. Sulfate content in the bottled water ranged between 3.31 to 76.22 mg/L, while higher level was determined (36.78 to 268.42 mg/L) in metropolitan water samples. The excellent quality parameters and insignificant matrix effects achieved during analysis have made favorable to analyze sulfate in water samples, and offered advantages over conventional techniques and rigorous sample preparation procedures.
Mohammad Rizwan Khan; Saikh Mohammad Wabaidur; Rosa Busquets; Ahmad Moid AlAmmari; Mohammad Azam; Ameen Alsubhi. Trace identification of sulfate anion in bottled and metropolitan water samples collected from various provinces of Saudi Arabia. Journal of King Saud University - Science 2020, 32, 1986 -1992.
AMA StyleMohammad Rizwan Khan, Saikh Mohammad Wabaidur, Rosa Busquets, Ahmad Moid AlAmmari, Mohammad Azam, Ameen Alsubhi. Trace identification of sulfate anion in bottled and metropolitan water samples collected from various provinces of Saudi Arabia. Journal of King Saud University - Science. 2020; 32 (3):1986-1992.
Chicago/Turabian StyleMohammad Rizwan Khan; Saikh Mohammad Wabaidur; Rosa Busquets; Ahmad Moid AlAmmari; Mohammad Azam; Ameen Alsubhi. 2020. "Trace identification of sulfate anion in bottled and metropolitan water samples collected from various provinces of Saudi Arabia." Journal of King Saud University - Science 32, no. 3: 1986-1992.
Bisphenol A (BPA) has been recognized as an endocrine disruptor, found in numerous products for instance water bottles, food cans and baby bottles. In this investigation, an improved method based on solid-phase extraction (SPE) and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was optimized for the extraction and identification of BPA in polyethylene terephthalate (PET) and glass bottled drinking water samples of diverse trademarks and origin. The extraction of BPA was carried out using Bond-Elut-C18 SPE cartridge without any further purification of the sample extracts. Under the most favorable extraction parameters, the system has revealed excellent linearity with correlation coefficient (R2 >0.999), limit of detection (0.01 µg/L), limit of quantification (0.04 µg/L) and precision in terms of intra- and inter-day, providing relative standard deviation (RSD%) values <1% (n = 5) and <3% (n = 5), respectively. The optimized system was applied for the analysis of BPA in drinking water samples, which showed that PET bottled samples contain lower amounts of BPA ranged from 0.29 µg/L to 24.88 µg/L, whereas glass bottled samples contain higher amounts of BPA ranged from 4.34 µg/L to 41.19 µg/L. The adequate recovery values were obtained between 96.81% and 99.77% in both type of samples.
Ahmad Moid AlAmmari; Mohammad Rizwan Khan; Ahmad Aqel. Trace identification of endocrine-disrupting bisphenol A in drinking water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. Journal of King Saud University - Science 2019, 32, 1634 -1640.
AMA StyleAhmad Moid AlAmmari, Mohammad Rizwan Khan, Ahmad Aqel. Trace identification of endocrine-disrupting bisphenol A in drinking water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. Journal of King Saud University - Science. 2019; 32 (2):1634-1640.
Chicago/Turabian StyleAhmad Moid AlAmmari; Mohammad Rizwan Khan; Ahmad Aqel. 2019. "Trace identification of endocrine-disrupting bisphenol A in drinking water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry." Journal of King Saud University - Science 32, no. 2: 1634-1640.
A novel zinc complex was prepared by the reaction of one equivalent of a bidentate Schiff base, N,N′-bis(2-chlorobenzylidene)-2,2-dimethylpropane-1,3-diamine, L with one equivalent of zinc chloride in methanol, and characterized by elemental analyses, NMR, IR and single crystal X-ray crystallography. The crystallographic studies revealed that the zinc ion in the complex is coordinated to two imine nitrogen atoms of L and two chloride ions of zinc chloride. Furthermore, to obtain insights into the structure and bonding, density functional theory (DFT) calculations were performed. The obtained results were found to be similar with the results obtained from the experimental findings. In addition, the anti-inflammatory activity of the studied zinc complex was also evaluated. The results obtained showed the studied complex could be a good candidate in treatment of inflammatory disorders.
Mohammad Azam; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Faiyaz Shakeel; Saied M. Soliman; Mahboob Alam; Mohammad Rizwan Khan; Saikh Mohammad Wabaidur. Zn(II) complex derived from bidentate Schiff base ligand: Synthesis, characterization, DFT studies and evaluation of anti-inflammatory activity. Journal of Molecular Structure 2019, 1201, 127177 .
AMA StyleMohammad Azam, Saud I. Al-Resayes, Agata Trzesowska-Kruszynska, Rafal Kruszynski, Faiyaz Shakeel, Saied M. Soliman, Mahboob Alam, Mohammad Rizwan Khan, Saikh Mohammad Wabaidur. Zn(II) complex derived from bidentate Schiff base ligand: Synthesis, characterization, DFT studies and evaluation of anti-inflammatory activity. Journal of Molecular Structure. 2019; 1201 ():127177.
Chicago/Turabian StyleMohammad Azam; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Faiyaz Shakeel; Saied M. Soliman; Mahboob Alam; Mohammad Rizwan Khan; Saikh Mohammad Wabaidur. 2019. "Zn(II) complex derived from bidentate Schiff base ligand: Synthesis, characterization, DFT studies and evaluation of anti-inflammatory activity." Journal of Molecular Structure 1201, no. : 127177.
In the current investigation, five most potential HAs (MeIQx, 4,8-DiMeIQx, IQ, MeIQ and PhIP) were analyzed in traditional Saudi chicken dishes (shawaya, Ala Al-Faham, kebab, saleeg, mandi, kabsa and madhbi) prepared from local restaurants. The aims of the present study were to identify the presence of HAs in cooked chicken dishes, and to conclude how the levels and types of HAs could be affected by cooking methods and food ingredients. In control samples, HAs were found at higher levels ranged from not quantified to 33.72 ng/g. Nonetheless, in chicken dishes, the HAs (MeIQx, 4,8-DiMeIQx and PhIP) amounts are varied at higher range and relatively detected at lower levels from not quantified to 16.35 ng/g, IQ and MeIQ were not identified in any of the studied chicken dishes except shawaya where found to be not quantified. The HAs reduction rates were obtained at higher values in all of the studied samples, among them mandi sample demonstrates the reduction rates higher than 70%, whereas saleeg sample shows the reduction rates almost 100% except PhIP (~95%). The obtained outcomes have markedly showed that HAs occurrence in thermally processed chicken dishes is extremely affected from both cooking methods and addition of food ingredients.
Ibrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Hazim Mohammed Ali; Mohammad Azam. Emergence of mutagenic/carcinogenic heterocyclic amines in traditional Saudi chicken dishes prepared from local restaurants. Food and Chemical Toxicology 2019, 132, 110677 .
AMA StyleIbrahim Hotan Alsohaimi, Mohammad Rizwan Khan, Hazim Mohammed Ali, Mohammad Azam. Emergence of mutagenic/carcinogenic heterocyclic amines in traditional Saudi chicken dishes prepared from local restaurants. Food and Chemical Toxicology. 2019; 132 ():110677.
Chicago/Turabian StyleIbrahim Hotan Alsohaimi; Mohammad Rizwan Khan; Hazim Mohammed Ali; Mohammad Azam. 2019. "Emergence of mutagenic/carcinogenic heterocyclic amines in traditional Saudi chicken dishes prepared from local restaurants." Food and Chemical Toxicology 132, no. : 110677.