Background/Objectives: Psoriasis is a chronic immune-mediated skin disease associated with several metabolic comorbidities. Metabolic dysfunction-associated steatotic liver disease (MASLD) is also linked to psoriasis, but evidence regarding the severity of this association remains inconclusive. This meta-analysis aimed to investigate the relationship between MASLD and varying severities of psoriasis. Methods: We conducted an extensive search of four databases, MEDLINE, EMBASE, OSF, and ClinicalTrials.gov to identify relevant published articles assessing the risk of prevalent MASLD in patients with moderate-to-severe psoriasis up to April 2024. Effect estimates from each included study were combined together to calculate a pooled effect estimate for the meta-analysis using the generic inverse variance method of DerSimonian and Laird. Results: This meta-analysis included eight studies with a total of 109,806 participants. A 4.01-fold increased risk of prevalent MASLD was observed in patients with moderate-to-severe psoriasis compared to those without psoriasis (95% CI: 2.17, 7.77; I² = 67%, p < 0.0001). The evidence supporting this outcome had low certainty. Conclusions: An incremental trend of MASLD was observed in patients with moderate-to-severe psoriasis. Routine screening for MASLD should be emphasized in this population.

Basal cell carcinoma (BCC) is the most common form of skin cancer and poses treatment challenges in advanced stages. Treatment options include surgery, radiotherapy, and systemic therapies, but tumor location and prior interventions can limit these methods. Hedgehog pathway inhibitors (HPIs) are used for patients unsuitable for conventional treatments. This meta-analysis evaluated the effectiveness and safety profile of HPIs in managing advanced BCC. We conducted a comprehensive literature review across Embase, Scopus, PubMed, and the Cochrane Central Register of Controlled Trials databases from inception until March 2024. The focus was on the effectiveness and safety of HPIs, with or without adjunct surgery or radiotherapy. Pooled objective response rates (ORRs) and 95% confidence intervals (CIs) were calculated using inverse variance random-effects models. The analysis comprised 16 studies, including 14 retrospective cohort studies, one prospective cohort study, and one randomized controlled trial, with 1689 participants. The pooled ORR for HPIs was 73% (95% CI 63%–82%; I² = 93%) across all stages of the disease. For locally advanced disease, the ORR was 63% (95% CI 49%–75%; I² = 89%), while for metastatic disease, it was 25% (95% CI 14%–40%; I² = 19%). No significant differences were found in the effectiveness of different HPIs. ORRs ranged from 25% to 89% for patients who underwent surgery or radiotherapy. This meta-analysis indicates that HPIs are more beneficial in treating locally advanced BCC than metastatic disease. No statistically significant differences were found in the effectiveness among various HPIs.