A male in his 20s with Burkitt lymphoma (BL) treated with chemotherapy was referred for lagophthalmos and left facial nerve palsy and re-evaluated weeks later due to acute scleral perforation. The perforated area was surgically closed, but on the first postoperative day, corneal thinning down to the Descemet membrane was noted, with iris adherence to the endothelium and progressive expansion of the affected sclera. Further globe reconstruction was deemed impossible; therefore, enucleation was performed. Histopathology revealed keratoconjunctivitis and acute perforative scleritis, though the aetiology could not be determined. A review of internal medicine records identified Pseudomonas aeruginosa bacteraemia, which may have been the underlying cause of the ocular condition. Intraocular involvement in BL is rare, and although P. aeruginosa is a leading cause of infective necrotising scleritis, scleral perforation due to this bacterium without prior surgery has not been reported.

This study presents a case and literature review of blurred vision as the first symptom of pancreatic cancer. A woman in her 60s was referred to our clinic because of visual impairment in her right eye. Ophthalmoscopic examination revealed a slightly elevated lesion in the macula. Primary tumour screening found a malignant mass in the cauda of the pancreas. According to Shields et al , pancreatic cancer with uveal metastasis has one of the least favourable survival rates. Our patient survived 20 months after the appearance of ophthalmic symptoms and had a good quality of life for a relatively long time. After reviewing all published data on intraocular metastases of pancreatic cancer, it becomes evident that the detection of the intraocular manifestation precedes the detection of the primary in half of the cases. Apparently, in fast-growing carcinomas, the symptomatology of the metastatic manifestation can precede the detection of the primary tumour.

We aimed to determine the effects of night-shift work on corneal parameters in thirty-five healthy individuals (24–59 years) in a retrospective cohort study. Among them, 12 hospital nurses regularly worked two shifts, spending a third of their nights awake, whereas 23 age-matched controls never worked shifts and slept regularly. Measurements were performed at least five times within 12 h. We analyzed the keratometric parameters of the corneal front (F) and back (B) surfaces, including the refractive power in the flattest and steepest axes (K1, K2), astigmatism (Astig); and corneal pachymetry (Pachy) at the thinnest corneal point and pupil center, volume relative to the 10 mm corneal diagonal (Vol D10); and surface variance index (ISV). A multilevel mixed-effects linear regression adjusted for age was applied to 905 measurements. All parameters exhibited significant periodic fluctuations (p ≤ 0.005). The two groups also showed significantly different periodic fluctuations (p ≤ 0.008), except in K1B and AstigB. K1/K2 (F and B), AstigF, Pachy, and ISV differed significantly (p < 0.0001). Surprisingly, prolonged night shift work did not increase the ISV, and no evidence of age-related corneal thinning was observed. Long-term night-shift exposures change various corneal parameters, reflecting both concomitant and adaptive effects. This study highlights the impact of consistent sleep deprivation on corneal properties, warranting further research into understanding the long-term effects of night-shift work.