Lemierre's syndrome (LS), otherwise known as postanginal sepsis, is a frequently overlooked condition characterized by septic thrombophlebitis of the internal jugular vein (IJV), usually caused by oropharyngeal infection. However, ear space (otogenic) infections are one of the atypical causes of LS and have been rarely reported. We present a case of a male in his 20s with a history of recurrent acute otitis media (RAOM) who presented with purulent ear discharge, fever, neck pain, and swelling for a week. Blood tests showed a raised white blood cell count with a left shift and increased inflammatory markers. Ear discharge and blood cultures were negative. A contrast‐enhanced computed tomography (CT) scan of the head and neck revealed thrombosis of the IJV and opacification of the mastoid air space. The patient was diagnosed with otogenic LS and recurrent acute otitis media and responded well to empiric broad‐spectrum antibiotics and supportive care. Anticoagulation therapy was not considered due to the lack of consensus on its effectiveness. After three months of follow‐up, symptoms resolved, and venous Doppler ultrasound showed IJV recanalization. This case highlights a rare association and emphasizes the need for timely diagnosis and intervention. Therefore, due to the rare occurrence of the disease, heightened clinical vigilance is needed to avoid the adverse consequences of delayed diagnosis.

Tuberculosis (TB) remains a major global public health challenge, significantly impacting morbidity and mortality. Assessing the patient-reported Health-Re

Neurosyphilis typically presents with nonspecific symptoms such as behavioral changes or cognitive impairment, rather than an initial stroke. This case report describes a Black African man in his thirties who experienced sudden weakness on the left side of his body. Computed tomography suggested a nucleo-capsular ischemic lesion. However, given his young age and lack of traditional stroke risk factors, further investigations were pursued. Laboratory tests revealed positive results for syphilis in both blood and cerebrospinal fluid. Additional imaging (head and neck angiography) indicated intracranial vasculitis with widespread and acute ischemia in the right hemisphere. Treatment with ceftriaxone and aspirin was initiated. Through ongoing monitoring and care, the patient’s neurological condition improved. The case underscores the critical need for prompt diagnosis and comprehensive assessment in patients experiencing stroke-like symptoms, especially in younger individuals. By recognizing neurosyphilis as a potential cause, healthcare providers can initiate timely treatment and improve patient outcomes.

Key Clinical Message: Understand the importance of considering alternative diagnosis in patients presenting with atypical features, specially when they are not responding to the standard treatment. Understand the importance of considering common presentations of rare cases. Underscoring the critical importance of timely recognition and appropriate management of potentially life‐threatening conditions.

Guillain–Barré syndrome (GBS) is an acute immune‐mediated polyradiculoneuropathy often triggered by infections. Malaria, a common parasitic disease in endemic regions, has rarely been associated with GBS. We report a case of a 21‐year‐old male from rural Ethiopia who developed GBS following Plasmodium vivax malaria. The patient presented with ascending paralysis, areflexia, dysphagia, dysarthria, and autonomic dysfunction. Cerebrospinal fluid (CSF) analysis revealed albumin‐cytologic dissociation, which further strengthens the diagnosis of GBS. He was successfully treated with intravenous immunoglobulin (IVIg) and supportive care. The patient achieved full recovery after 8 weeks from the onset of weakness. This case highlights the importance of considering GBS in patients with recent malaria infection and neurological deficits, particularly in malaria‐endemic regions. The rarity of such cases in the literature and the unique clinical course make this report noteworthy.

Key Clinical Message: Understand the importance of considering alternative diagnosis in patients presenting with atypical features. Understand the importance of considering common presentations of rare cases. Underscoring the critical importance of timely recognition and appropriate management of potentially life‐threatening condition.