Parasitic infections remain a significant public health challenge in West Africa, contributing to high morbidity and mortality rates, economic burdens, and healthcare system strain. Malaria, soil-transmitted helminths, schistosomiasis, and other parasitic diseases persist due to environmental, socio-economic, and healthcare barriers. A systematic literature search was conducted using databases such as PubMed, Scopus, Web of Science, and Science Direct. Studies published between 2014 and 2024 were screened using predefined eligibility criteria. Cross-sectional and case–control studies reporting on prevalence, diagnostic techniques, and treatment of parasitic infections in West Africa were included. The Rayyan online platform was used for screening, and data extraction focused on study location, prevalence rates, diagnostic methods, and treatment regimens. This review identified the high prevalence rates of malaria, schistosomiasis, and soil-transmitted helminths across various West African countries. Co-infections were frequently reported, particularly among children and pregnant women. Diagnostic methods ranged from traditional microscopy to advanced molecular techniques, though accessibility remained a challenge in resource-limited settings. Treatment strategies, including artemisinin-based combination therapies for malaria and mass drug administration for helminths, showed varying efficacy due to reinfection risks and emerging drug resistance. Factors influencing transmission included environmental conditions, sanitation practices, socio-economic status, and healthcare access. Parasitic infections in West Africa continue to pose significant health and economic challenges. Integrated control programs, enhanced surveillance systems, improved access to diagnostics and treatment, and targeted public health interventions are essential for reducing disease burden. Further research is needed to evaluate the long-term impact of existing interventions and explore innovative solutions for parasite control and elimination.

Background and Aim: Human giardiasis poses a significant public health challenge globally, particularly in resource‐limited countries due to poor personal hygiene, environmental sanitation, and unsafe water. It affects approximately 300 million people globally every year, and children are the most at‐risk population. This scoping review assesses the burden, transmission dynamics, and public health implications of human giardiasis in Ghana. Methods: A comprehensive search strategy across PubMed, African Journals Online, Science Direct, Scopus and Web of Science databases using key terms “Giardia duodenalis,” “Giardia intestinalis,” and “Giardiasis.” Published articles on Human giardiasis in Ghana between 2004 and 2024 on epidemiology, prevalence, diagnostic methods, and target populations were extracted. Results: Seventeen studies conducted in Ghana met the inclusion criteria and were included in this review. The prevalence of Giardia duodenalis in Ghana varies significantly across studies and settings, with rates ranging from 0.7% to 59.6%, with children being the most affected. However, studies conducted in Ghana since 2020 indicate a lower prevalence, with rates between 0.7% and 13.0%. Regional studies indicate varied prevalence: 0.7%–13.0%, 2.3%–59.6%, and 5.9% in the Southern, Middle, and Northern belts, respectively. Conclusion: The prevalence of human giardiasis in Ghana is relatively low. However, targeted public health interventions are necessary to maintain the progress achieved, in addition to improvements in sanitation and hygiene practices.