Repetitive head impacts (RHI) sustained in contact sports are thought to be necessary for the long-term development of chronic traumatic encephalopathy (CTE). Our objectives were to: 1) characterize the magnitude and persistence of RHI-induced white matter (WM) changes; 2) determine their relationship to kinematic measures of RHI; and 3) explore their clinical relevance. Prospective, observational study of 10 Division III college football players and 5 non-athlete controls during the 2011-12 season. All subjects underwent diffusion tensor imaging (DTI), physiologic, cognitive, and balance testing at pre-season (Time 1), post-season (Time 2), and after 6-months of no-contact rest (Time 3). Head impact measures were recorded using helmet-mounted accelerometers. The percentage of whole-brain WM voxels with significant changes in fractional anisotropy (FA) and mean diffusivity (MD) from Time 1 to 2, and Time 1 to 3 was determined for each subject and correlated to head impacts and clinical measures. Total head impacts for the season ranged from 431–1,850. No athlete suffered a clinically evident concussion. Compared to controls, athletes experienced greater changes in FA and MD from Time 1 to 2 as well as Time 1 to 3; most differences at Time 2 persisted to Time 3. Among athletes, the percentage of voxels with decreased FA from Time 1 to 2 was positively correlated with several helmet impact measures. The persistence of WM changes from Time 1 to 3 was also associated with changes in serum ApoA1 and S100B autoantibodies. WM changes were not consistently associated with cognition or balance. A single football season of RHIs without clinically-evident concussion resulted in WM changes that correlated with multiple helmet impact measures and persisted following 6 months of no-contact rest. This lack of WM recovery could potentially contribute to cumulative WM changes with subsequent RHI exposures.

The acknowledgement of risks for traumatic brain injury in American football players has prompted studies for sideline concussion diagnosis and testing for neurological deficits. While concussions are recognized etiological factors for a spectrum of neurological sequelae, the consequences of sub-concussive events are unclear. We tested the hypothesis that blood-brain barrier disruption (BBBD) and the accompanying surge of the astrocytic protein S100B in blood may cause an immune response associated with production of auto-antibodies. We also wished to determine whether these events result in disrupted white matter on diffusion tensor imaging (DT) scans. Players from three college football teams were enrolled (total of 67 volunteers). None of the players experienced a concussion. Blood samples were collected before and after games (n = 57); the number of head hits in all players was monitored by movie review and post-game interviews. S100B serum levels and auto-antibodies against S100B were measured and correlated by direct and reverse immunoassays (n = 15 players; 5 games). A subset of players underwent DTI scans pre- and post-season and after a 6-month interval (n = 10). Cognitive and functional assessments were also performed. After a game, transient BBB damage measured by serum S100B was detected only in players experiencing the greatest number of sub-concussive head hits. Elevated levels of auto-antibodies against S100B were elevated only after repeated sub-concussive events characterized by BBBD. Serum levels of S100B auto-antibodies also predicted persistence of MRI-DTI abnormalities which in turn correlated with cognitive changes. Even in the absence of concussion, football players may experience repeated BBBD and serum surges of the potential auto-antigen S100B. The correlation of serum S100B, auto-antibodies and DTI changes support a link between repeated BBBD and future risk for cognitive changes.

A significant fraction of planetary nebulae (PNe) and protoplanetary nebulae (PPNe) exhibit aspherical, axisymmetric structures, many of which are hi

We develop a new nonlinear mean field dynamo theory that couples field growth to the time evolution of the magnetic helicity and the turbulent electromotive force, $\overline{\mathcal{E}}$. We show that the difference between kinetic and current helicities emerges naturally as the growth driver when the time derivative of $\overline{\mathcal{E}}$ is coupled into the theory. The solutions predict significant field growth in a kinematic phase and a saturation rate/strength that is magnetic Reynolds number dependent/independent in agreement with numerical simulations. The amplitude of early time oscillations provides a diagnostic for the closure.

The time-averaged 30 ks Chandra HETGS observation of the micro-quasar GRS 1915+105 in the low hard state reveals for the first time in this source neutral K absorption edges from Fe, Si, Mg, & S. Ionized resonance absorption from H-, and He-like Fe (XXV, XXVI), Ca XX and possibly emission from neutral Fe Kalpha and ionized Fe XXV (forbidden, or the resonance emission component of a P-Cygni profile) are also seen. We report the tentative detection of the first astrophysical signature of XAFS in the photoelectric edge of Si (and possibly Fe and Mg), attributed to material in grains. The large column densities measured from the neutral edges reveal anomalous Si and Fe abundances. Scenarios for which the anomalous abundances can be attributed to surrounding cold material associated with GRS 1915+105 and/or that the enrichment may signify either a highly unusual supernova/hypernova, or external supernova activity local to the binary are discussed. We attribute the ionized features to a hot disk, disk-wind, or corona environment. These features allow for constraints on the ionization parameter (log xi > 4.15), temperature (T > 2.4 x 10^6 K), and hydrogen equivalent number density (n > 10^{12} cm^{-3}) for this region. Variability studies with simultaneous RXTE data show that the light curve count rate tracks changes in the disk blackbody and the power-law flux. Spectral changes in the Chandra data also track the behavior of the light curve, and may point to changes in both the ionizing flux and density of the absorber. A 3.69 Hz QPO and weak first harmonic is seen in the RXTE data.Comment: Accepted for publication in ApJ., 9 pages, 5 figure

The evolution of laboratory produced magnetic jets is followed numerically through three-dimensional, nonideal magnetohydrodynamic simulations. The experiments are designed to study the interaction of a purely toroidal field with an extended plasma background medium. The system is observed to evolve into a structure consisting of an approximately cylindrical magnetic cavity with an embedded magnetically confined jet on its axis. The supersonic expansion produces a shell of swept-up shocked plasma that surrounds and partially confines the magnetic tower. Currents initially flow along the walls of the cavity and in the jet but the development of current-driven instabilities leads to the disruption of the jet and a rearrangement of the field and currents. The top of the cavity breaks up, and a well-collimated, radiatively cooled, “clumpy” jet emerges from the system.