The spacecraft microgravity simulation air-bearing platform is a crucial component of the spacecraft ground testing system. Special disturbances, such as the flatness and roughness of the contact surface between the air bearings and the granite platform, increasingly affect the control accuracy of the simulation experiment as the number of air bearings increases. To address this issue, this paper develops a novel compensation control system based on Active Disturbance Rejection Control (ADRC), which estimates and compensates for the disturbing forces and moments caused by the roughness and levelness of the contact surface, thereby improving the control precision of the spacecraft ground simulation system. A dynamic model of the multi-air-bearing platform under disturbance is established. A cascade ADRC algorithm based on the Linear Extended State Observer (LESO) is designed. The Gauss–Newton iteration method is used to identify the parameters of the sliding friction coefficient and the tilt angle of the air-bearing platform. A full-physics simulation experimental platform for spacecraft with rotor-based propulsion is constructed, and the proposed algorithm is validated. The experimental results show that on a marble surface with a flatness of grade 00, an overall tilt angle of 0–1 degrees, and a surface friction coefficient of 0–0.01, the position control accuracy for the simulated spacecraft can reach 1.5 cm, and the attitude control accuracy can reach 1°. Under ideal conditions, the identification accuracy for the contact surface friction coefficient is 2 × 10⁻⁴, and the recognition accuracy for the overall levelness of the marble surface can reach 1 × 10⁻³, laying the foundation for high-precision ground simulation experiments of spacecraft in multi-air-bearing scenarios.