Digital twin (DT) technology has become a key enabler for prognostics and health management (PHM) in complex industrial systems, yet scaling predictive models for multi-component degradation (MCD) scenarios remains challenging, particularly when transferring insights from predictive models of smaller systems developed with limited data to larger systems. To address this, a physics-informed neural network (PINN) framework that integrates a standardized scaling methodology, enabling scalable DT analytics for MCD prognostics, was developed in this paper. Our approach employs a systematic DevOps workflow that features containerized PINN DT analytics deployed on a Kubernetes cluster for dynamic resource optimization, a real-time DT platform (PTC ThingWorx™), and a custom API for bidirectional data exchange that connects the cluster to the DT platform. A key contribution of this paper is the scalable DT model, which facilitates transfer learning of degradation patterns across heterogeneous hydraulic systems. Three (3) hydraulic system configurations were modeled, analyzing multi-component filter degradation under pump speeds of 700–900 RPM. Trained on limited data from a reference system, the scaled PINN model achieved 88.98% accuracy for initial degradation detection at 900 RPM—outperforming an unscaled baseline of 64.13%—with consistent improvements across various speeds and thresholds. This work advances PHM analytics by reducing costs and development time, providing a scalable framework for cross-system DT deployment.