Remote driving, i.e., the capacity of controlling road vehicles at a distance, is an innovative transportation technology often associated with potential ethical benefits, especially when deployed to tackle urban traffic issues. However, prospected benefits could only be reaped if remote driving can be executed in a safe and responsible way. This paper builds on notions elaborated in the philosophical literature on technological mediation to offer a systematic examination of the extent to which current and emerging Human–Machine Interfaces contribute to hindering or supporting the exercise of responsibility behind the remote wheel. More specifically, the analysis discusses how video, audio, and haptic interfaces co-shape the remote driving experience and, at the same time, the operators’ capacity to drive responsibly. The multidisciplinary approach explored in this research offers a novel methodological framework to structure future empirical inquiries while identifying finely tuned multi-sensory HMIs and dedicated training as critical presuppositions to the remote drivers’ exercise of responsibility.