In this article, we establish the weighted $(k,s)$-Riemann-Liouville fractional integral and differential operators. Some certain properties of the operators and the weighted generalized Laplace transform of the new operators are part of the paper. The article consists of Chebyshev-type inequalities involving a weighted fractional integral. We propose an integro-differential kinetic equation using the novel fractional operators and find its solution by applying weighted generalized Laplace transforms.

Mathematics and physics are deeply interconnected. In fact, physics relies on mathematical tools like calculus and differential equations. The aim of this article is to introduce tempered Riemann–Liouville (RL) fractional operators and their properties with applications in mathematical physics. The tempered RL substantial fractional derivative is also defined, and its properties are discussed. The Laplace transforms (LTs) of the introduced fractional operators are evaluated. The Hyers–Ulam stability and the existence of a novel tempered fractional differential equation are examined. Moreover, a fractional integro-differential kinetic equation is formulated, and the LT is used to find its solution. A growth model and its graphical representation are established, highlighting the role of novel fractional operators in modeling complex dynamical systems. The developed mathematical framework offers valuable insights into solving a range of scenarios in mathematical physics.