Background and Objectives: Receptors of the advanced glycation products (RAGE) are activated to promote cell death and contributes to chronic diseases such as diabetes and inflammation. Advanced glycation end products (AGEs), which interact with RAGE are complex compounds synthesized during diabetes development and are presumed to play a significant role in pathogenesis of diabetes. Phosphatidylcholine (PC), a polyunsaturated fatty acid found in egg yolk, mustard, and soybean, is thought to exert anti-inflammatory activity. We investigated the effects of PC on AGEs-induced hepatic and renal cell injury. Materials and Methods: In this study, we evaluated cytokine and NF-κB/MAPK signal pathway activity in AGEs induced human liver (HepG2) cells and human kidney (HK2) cells with and without PC treatment. Results: PC reduced RAGE expression and attenuated levels of inflammatory cytokines and NF-kB/MAPK signaling. Moreover, cells treated with PC exhibited a significant reduction in cytotoxicity, oxidative stress, and inflammatory factor levels. Conclusions: These findings suggest that PC could be an effective functional material for hepatic and renal injury involving with oxidative stress caused by AGEs during diabetic conditions.

Advanced glycation end-products (AGEs) and their receptor cause diabetic liver disease by increasing oxidative stress and inflammation. We investigate the potential therapeutic benefits of Cirsium japonicum (CJ) in preventing the progression of diabetes, focusing on complications for both liver and kidney health associated with AGEs. Streptozotocin (STZ, 30 mg/kg) was injected into SD rats and CJ (50, 100 mg/kg) was orally administered for 4 weeks. CJ treatment led to a marked reduction in key diabetic markers (glucose, reaction oxygen species, and lactate dehydrogenase), compared with the rats treated only with STZ. Moreover, the hepatic tissues of STZ-treated rats exhibited heightened biomarkers associated with AGE induction and formation, and these were notably attenuated in the CJ-treated rats. This effectively alleviated oxidative stress, inflammation, and AGE accumulation in the liver. Similarly, in the context of diabetic nephropathy, CJ treatment resulted in significant improvements in the rats with STZ-induced diabetes. Biomarkers associated with AGE induction and formation were significantly reduced in CJ-treated rats, demonstrating the ability of CJ to combat renal oxidative stress, inflammation, and AGE-related complications in diabetic nephropathy. CJ thus shows potential as a promising natural remedy that might mitigate the detrimental effects of diabetes on both the liver and kidneys through its anti-oxidation, anti-inflammation, and anti-AGE activities. These findings suggest that CJ is a beneficial agent for preventing and treating diabetic complications.

Capsular contracture is a common complication following breast implant surgery and is primarily associated with peri-implant fibrotic responses. This study evaluated the effects of an acellular dermal matrix (ADM) powder–coated breast implant on capsular contracture–related outcomes using a rabbit model. Non-textured, smooth-surface breast implants coated with ADM powder were implanted into the subpectoral pocket, and peri-implant tissues were harvested 12 weeks after implantation. Capsule thickness was assessed using hematoxylin and eosin (H&E) staining, while fibrotic changes were evaluated by measuring collagen density in Masson’s trichrome (MT)–stained sections. Immunohistochemical analysis was performed to examine the expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β). Compared with conventional breast implants, ADM powder–coated implants demonstrated a reduction in capsule thickness and collagen density, along with decreased expression of α-SMA and TGF-β. These results indicate that ADM powder coating may attenuate peri-implant fibrotic responses and may represent a feasible and cost-effective approach for reducing capsular contracture.

Capsular contracture is a common complication following breast implant surgery and is primarily associated with peri-implant fibrotic responses. This study evaluated the effects of an acellular dermal matrix (ADM) powder-coated breast implant on capsular contracture-related outcomes using a rabbit model. Non-textured, smooth-surface breast implants coated with ADM powder were implanted into the subpectoral pocket, and peri-implant tissues were harvested 12 weeks after implantation. Capsule thickness was assessed using hematoxylin and eosin (H&E) staining, while fibrotic changes were evaluated by measuring collagen density in Masson’s trichrome (MT)-stained sections. Immunohistochemical analysis was performed to examine the expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β). Compared with non-textured smooth (NTS) surface breast implants, ADM powder-coated implants demonstrated reduced capsule thickness and collagen density, together with decreased expression of α-SMA and TGF-β. These results suggest that ADM powder coating may attenuate peri-implant fibrotic responses and serve as a feasible approach for reducing capsular contracture.

Background: Skin photoaging caused by ultraviolet B (UV-B) irradiation leads to the formation of wrinkles. A method to lessen wrinkles is the application of Polydioxanone (PDO) lifting threads. HanDam (Twist) is a PDO lifting thread with a unique morphological twisted shape. Objective: The aim of this study was to evaluate the wrinkle improvement ability of HanDam (Twist) on UV-B irradiation-induced skin photoaging in a hairless mouse model. Methods: Wrinkles were induced by UV-B irradiation to the backs of female hairless mice for six weeks. After induction, the wrinkles were treated with threads, and the mice were monitored for six weeks post-treatment. Results: Our results showed that treatment with HanDam (Twist) effectively ameliorated UV-B irradiation-induced wrinkle depth and significantly increased collagen density by 13% compared to HanDam (non-Twist) in the histological analysis. In measuring protein expression related to collagen production, HanDam (Twist) significantly increased transforming growth factor beta (TGF-β) and collagen type 1 (COL1) by 46% and 67% compared to HanDam (non-Twist). Matrix metalloproteinase-1 (MMP-1) protein expression showed similar density and no significance compared to HanDam (non-Twist). Conclusions: These findings suggest that HanDam (Twist) improves the effectiveness of lifting threads for skin care compared to that of existing products.