Durian (Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of Durio zibethinus (D. zibethinus) on human leukemia (HL-60) cells. The methanolic extract of D. zibethinus fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of D. zibethinus fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction (p < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of D. zibethinus exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.

Different types of batteries (BT’s) are also used every day and a significant amount of waste BT’s are created at the end of the day. Waste BT’s can lead to grave contamination of the atmosphere. Currently, the major waste BT processes are incineration and waste disposal, solidification management, manual processing, wet recuperation technology, dry recovery techniques and bio metallurgical (BM) technology. This paper describes many waste BT disposal practises and its impact in recent years.

Plastic ruminal impaction is a disorder that allows the ruminant ruminants to aggregate in indigestible plastic foreign bodies contributing to impacted ruminations, indigestibility, chronic tympani, and many others. The ruminants are fed indigestible plastic waste products without discrimination. In the urban regions of the developed world, the disease is mostly found in stray animals. The chemicals in the rumen, which are absorbed in the food chain by milk or meat products, are steadily discharged in the rumen. The harm to human wellbeing is done by these substances. Currently, the only alternative is to detect and treat ruminal impaction due to plastic materials in ruminants for exploratory rumenotomy. Good animal husbandry methods and proper handling of waste plastic are included in the control mechanisms. The present study examines in detail and illustrates its effect on public health on epidemiology, pathophysiology; detection, care, prevention, and regulation of ruminal impaction caused by ruminant plastics.

This study aimed to investigate the phytochemical composition of eucalyptus oil and evaluate its antifungal properties against Candida species. Qualitative phytochemical analysis revealed the presence of various compounds, including carbohydrates, flavonoids, phenols, proteins, quinones, saponins, and tannins. Flavonoids were found to have the highest concentration, followed by tannins and polyphenols. GC-MS analysis identified several compounds in eucalyptus oil, including 2,3-Diamino-2-cyanosuccinonitrile as a major component. Antifungal assays demonstrated that eucalyptus oil inhibited the growth of Candida albigans, Candida tropicalis and Candida kefyr, with varying degrees of inhibition depending on the concentration used. The antifungal activity may be attributed to the presence of bioactive compounds such as 1-Butyne, 3-methyl-, 1-Hexen-4-ol, 1-chloro-3-methyl, N-(Methylphenylamino) methyl) benzamide. Further studies are required to explore the specific role and potential benefits of the identified compounds in eucalyptus oil and to evaluate the effectiveness of eucalyptus oil as an antifungal agent in clinical settings.

Coronavirus disease 2019 (COVID-19) has a negative effect on the poor, minority populations, and a wide variety of vulnerable communities because of its unequal distribution in populated regions and its limited ability to be mitigated by the rise in chronic conditions or the lack of access to high-quality healthcare (HC). Furthermore, the pandemic's negative consequences, such as social isolation and travel limitations, disproportionately affect persons in the poorest socioeconomic (SE) groups. We prepared seven national case studies from across the world to address the difficulties of improving health and highlight some of the responses used by government agencies and local groups: Afghanistan (AFGN), Albania (ALB), Algeria (ALGR), Australia (AU), Brazil (BR), China (CN), and France (FR). We encourage academics to continue doing rigorous research and establishing a sound evidence foundation for further scientific inquiries into COVID-19 health equity problems throughout the world. HC organisations may improve their agility, resilience, and learning with the support of insights from complexity science in order to better prepare for unexpected occurrences in the future.