Peer reviewed article authored by (Silva AC, Oliveira TR, Mamani JB, Malheiros SMF, Malavolta L, Pavon LF, Sibov TT, Amaro E Jr, Tannús A, Vidoto ELG, Matins MJ, Santos RS, Gamarra LF). Read article or submit your manuscript for publishing.

A technique is described for performing frequency‐selective signal suppression with a high degree of tolerance to RF field inhomogeneity. The method is called B₁‐insensitive train to obliterate signal (BISTRO). BISTRO consists of multiple amplitude‐ and frequency‐modulated (FM) pulses interleaved with spoiler gradients. BISTRO was developed for the purpose of accomplishing band‐selective signal removal, as in water suppression and outer‐volume suppression (OVS), in applications requiring the use of an inhomogeneous RF transmitter, such as a surface coil. In the present work, Bloch simulations were used to illustrate the principles and theoretical performance of BISTRO. Its performance for OVS was evaluated experimentally using MRI and spectroscopic imaging of phantoms and in vivo animal and human brain. By using FM pulses featuring offset‐independent adiabaticity, BISTRO permitted high‐quality, broadband suppression with one (or two) discrete borders demarcating the edge(s) of the suppression band. Simulations and experiments demonstrated the ability to operate BISTRO with reasonably attainable peak RF power levels and with average RF energy deposition similar to other multipulse OVS techniques. Magn Reson Med 45:1095–1102, 2001.