Diagnosis and treatment of colorectal cancer： Developed a clinical cohort of colorectal cancer patients to investigate key molecular markers influencing patient prognosis and treatment response. Utilized clinical pathology, imaging, and gut microbiota analysis to identify potential biomarkers. Constructed a robust survival prediction model for long-term prognosis. Conducted cell and animal experiments with novel nanomolecular drugs to elucidate specific molecular mechanisms and enhance treatment efficacy for colorectal cancer patients.