The operational variables used to adjust the control level of the copper cleaner flotation process have a noticeable impact on the object variables, e.g., the copper concentrate grade. Currently, due to the complexity of the flotation process, the operational variables, which are controlled by operators, are often not adjusted properly in time. Hence, this article investigates an intelligent operational adjustment framework based on a hybrid Bayesian network (BN). The offline BN model structure and the parameters are established based on process knowledge and real industrial data, respectively. After receiving the expected value of the copper concentrate grade as evidence, an operational adjustment can be obtained online by BN reasoning. To ensure its credibility, the copper concentrate grade after operational adjustment is further predicted. According to the predicted value, the operators can determine whether to implement the operational adjustment or not. Finally, the experimental results show the effectiveness and practical significance of the proposed method.