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Dr. Wolfgang Uter
Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University of Erlangen-Nuremberg, 91054 Erlangen, Germany

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0 Allergens
0 Allergy
0 Dermatology
0 Epidemiology
0 Skin

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contact dermatitis
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Original article
Published: 28 June 2021 in Contact Dermatitis
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Background The contact allergy prevalences in patch tested patients are usually higher than those in the population, owing to morbidity-driven selection. Objectives To examine the differences between two samples, one from the population, one from the patch test clinic, in one area of Germany (Jena, Thuringia). Methods Between August 2008 and October 2011, 519 participants of the population-based EDEN fragrance study were patch tested in Jena using a TRUE Test baseline series extended with some pet.-based (fragrance) allergen preparations. Between 2007 and 2012 (inclusive), 1906 routine patients were patch tested for suspected ACD in the Jena University Hospital Department, of these 1694 (83.2%) with the German baseline series using pet./aq.-based, investigator-loaded allergens. Results In the population (clinical) sample, 19.6% (41.1%) were sensitised to at least one of the allergens considered. The most common baseline series allergens in the population/clinical sample were nickel (10.5%/13.2%), fragrance mix (FM) II (2.9%/6.7%), FM I (2.3%/8.3%), and cobalt (1.6%/5%). The clinical sample was slightly older (71.5% vs. 55.9% age 40+) and included less males (36% vs. 49.3%). Conclusions Results are quite similar, although prevalences are usually higher in the clinical setting, with the exception of p-tert-butylphenol formaldehyde resin.

ACS Style

Wolfgang Uter; Anica Zetzmann; Robert Ofenloch; Sibylle Schliemann; Magnus Bruze; Margarida Gonçalo; Luigi Naldi; Marie‐Louise A. Schuttelaar; Åke Svensson; Peter Elsner; the EDEN Fragrance Study Group. Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany. Contact Dermatitis 2021, 1 .

AMA Style

Wolfgang Uter, Anica Zetzmann, Robert Ofenloch, Sibylle Schliemann, Magnus Bruze, Margarida Gonçalo, Luigi Naldi, Marie‐Louise A. Schuttelaar, Åke Svensson, Peter Elsner, the EDEN Fragrance Study Group. Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany. Contact Dermatitis. 2021; ():1.

Chicago/Turabian Style

Wolfgang Uter; Anica Zetzmann; Robert Ofenloch; Sibylle Schliemann; Magnus Bruze; Margarida Gonçalo; Luigi Naldi; Marie‐Louise A. Schuttelaar; Åke Svensson; Peter Elsner; the EDEN Fragrance Study Group. 2021. "Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany." Contact Dermatitis , no. : 1.

Review
Published: 21 March 2021 in Contact Dermatitis
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Existing criteria for inclusion in the European baseline series are summarised. Additional criteria are developed to aid decision making where the current criteria do not yield an unequivocal result. These include a consideration of whether an allergen (hapten) is better placed in a special series and the frequency with which an allergen cross‐reacts with existing markers in the baseline series.

ACS Style

S Mark Wilkinson; Sonia Badulici; Ana Giménez‐Arnau; Heinrich Dickel; Margarida Gonçalo; Marcos Hervella; Marléne Isaksson; Jeanne D Johansen; Vera Mahler; Jacob P Thyssen; Wolfgang Uter; European Baseline Series Taskforce Of The European Society Of Contact Dermatitis. The European baseline series: Criteria for allergen inclusion with reference to formaldehyde releasers. Contact Dermatitis 2021, 85, 125 -128.

AMA Style

S Mark Wilkinson, Sonia Badulici, Ana Giménez‐Arnau, Heinrich Dickel, Margarida Gonçalo, Marcos Hervella, Marléne Isaksson, Jeanne D Johansen, Vera Mahler, Jacob P Thyssen, Wolfgang Uter, European Baseline Series Taskforce Of The European Society Of Contact Dermatitis. The European baseline series: Criteria for allergen inclusion with reference to formaldehyde releasers. Contact Dermatitis. 2021; 85 (2):125-128.

Chicago/Turabian Style

S Mark Wilkinson; Sonia Badulici; Ana Giménez‐Arnau; Heinrich Dickel; Margarida Gonçalo; Marcos Hervella; Marléne Isaksson; Jeanne D Johansen; Vera Mahler; Jacob P Thyssen; Wolfgang Uter; European Baseline Series Taskforce Of The European Society Of Contact Dermatitis. 2021. "The European baseline series: Criteria for allergen inclusion with reference to formaldehyde releasers." Contact Dermatitis 85, no. 2: 125-128.

Journal article
Published: 17 March 2021 in Contact Dermatitis
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Background Irritant contact dermatitis (ICD) is caused by the acute locally toxic effect of a strong irritant, or the cumulative exposure to various weaker physical and/or chemical irritants. Objectives To describe characteristics of patients with ICD in the population patch tested in the European Surveillance System on Contact Allergies (ESSCA; www.essca‐dc.org) database. Methods Data collected by the ESSCA in consecutively patch tested patients from January 2009 to December 2018 were analyzed. Results Of the 68 072 patients, 8702 patients were diagnosed with ICD (without concomitant allergic contact dermatitis [ACD]). Hand and face were the most reported anatomical sites, and 45.7% of the ICD was occupational ICD (OICD). The highest proportions of OICD were found in metal turners, bakers, pastry‐cooks and confectionery makers. Among patients diagnosed with ICD, 45% were found sensitized with no relevance for the current disease. Conclusions The hands were mainly involved in OICD also in the subgroup of contact dermatitis patients, in whom relevant contact sensitization had been ruled out, emphasizing the need for limiting irritant exposures. However, in difficult to treat contact dermatitis, unrecognized contact allergy, or unrecognized clinical relevance of identified allergies owing to incomplete or wrong product ingredient information must always be considered.

ACS Style

Laura Loman; Wolfgang Uter; José C. Armario‐Hita; Fabio Ayala; Anna Balato; Barbara K. Ballmer‐Weber; Andrea Bauer; Andreas J. Bircher; Timo Buhl; Magdalena Czarnecka‐Operacz; Heinrich Dickel; Thomas Fuchs; Ana Giménez Arnau; Swen M. John; Birger Kränke; Beata Kręcisz; Vera Mahler; Thomas Rustemeyer; Anna Sadowska‐Przytocka; Javier Sánchez‐Pérez; Kathrin Scherer Hofmeier; Sibylle Schliemann; Dagmar Simon; Radoslaw Spiewak; Philip Spring; Skaidra Valiukevičienė; Nicola Wagner; Elke Weisshaar; Maria Pesonen; Marie L. A. Schuttelaar; ESSCA Working Group. European Surveillance System on Contact Allergies (ESSCA): Characteristics of patients patch tested and diagnosed with irritant contact dermatitis. Contact Dermatitis 2021, 85, 186 -197.

AMA Style

Laura Loman, Wolfgang Uter, José C. Armario‐Hita, Fabio Ayala, Anna Balato, Barbara K. Ballmer‐Weber, Andrea Bauer, Andreas J. Bircher, Timo Buhl, Magdalena Czarnecka‐Operacz, Heinrich Dickel, Thomas Fuchs, Ana Giménez Arnau, Swen M. John, Birger Kränke, Beata Kręcisz, Vera Mahler, Thomas Rustemeyer, Anna Sadowska‐Przytocka, Javier Sánchez‐Pérez, Kathrin Scherer Hofmeier, Sibylle Schliemann, Dagmar Simon, Radoslaw Spiewak, Philip Spring, Skaidra Valiukevičienė, Nicola Wagner, Elke Weisshaar, Maria Pesonen, Marie L. A. Schuttelaar, ESSCA Working Group. European Surveillance System on Contact Allergies (ESSCA): Characteristics of patients patch tested and diagnosed with irritant contact dermatitis. Contact Dermatitis. 2021; 85 (2):186-197.

Chicago/Turabian Style

Laura Loman; Wolfgang Uter; José C. Armario‐Hita; Fabio Ayala; Anna Balato; Barbara K. Ballmer‐Weber; Andrea Bauer; Andreas J. Bircher; Timo Buhl; Magdalena Czarnecka‐Operacz; Heinrich Dickel; Thomas Fuchs; Ana Giménez Arnau; Swen M. John; Birger Kränke; Beata Kręcisz; Vera Mahler; Thomas Rustemeyer; Anna Sadowska‐Przytocka; Javier Sánchez‐Pérez; Kathrin Scherer Hofmeier; Sibylle Schliemann; Dagmar Simon; Radoslaw Spiewak; Philip Spring; Skaidra Valiukevičienė; Nicola Wagner; Elke Weisshaar; Maria Pesonen; Marie L. A. Schuttelaar; ESSCA Working Group. 2021. "European Surveillance System on Contact Allergies (ESSCA): Characteristics of patients patch tested and diagnosed with irritant contact dermatitis." Contact Dermatitis 85, no. 2: 186-197.

Journal article
Published: 19 February 2021 in Healthcare
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(1) Background: Different sources of information are used by the population regarding skin cancer prevention. The pertinent quality of information that can be retrieved via an internet search engine needs assessment; (2) Methods: Four topical searches in common language were entered into Google™. The first 200 “hits” were stored for further use. Eligible websites were evaluated using content-based criteria based on the current German medical guideline “Skin cancer prevention” and employing generic (DISCERN, HONcode) quality criteria. (3) Results: Overlap between the four search results was between 0 and 7 of 200. The completeness of relevant content was scored with a median of 10 points (first quartile (Q1):6; Q3:14) and thus, it was much lower than the theoretical maximum of 43 points. Global quality, with a maximum of 10 points, was 3 in median (Q1:2; Q3:4). Quality and completeness, respectively, were somewhat higher in the higher ranks of search results. The generic quality was moderate. (4) Conclusions: A direct comparison with other sources of information (print, audio-visual, presentation, or personal counselling) is not possible, but important deficits concerning the quality and scope of relevant information on the internet are demonstrated.

ACS Style

Wolfgang Uter; Christina Eversbusch; Olaf Gefeller; Annette Pfahlberg. Quality of Information for Skin Cancer Prevention: A Quantitative Evaluation of Internet Offerings. Healthcare 2021, 9, 229 .

AMA Style

Wolfgang Uter, Christina Eversbusch, Olaf Gefeller, Annette Pfahlberg. Quality of Information for Skin Cancer Prevention: A Quantitative Evaluation of Internet Offerings. Healthcare. 2021; 9 (2):229.

Chicago/Turabian Style

Wolfgang Uter; Christina Eversbusch; Olaf Gefeller; Annette Pfahlberg. 2021. "Quality of Information for Skin Cancer Prevention: A Quantitative Evaluation of Internet Offerings." Healthcare 9, no. 2: 229.

Original article
Published: 16 January 2021 in Contact Dermatitis
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Background Hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) has been the most reported fragrance chemical for two decades and will be prohibited in cosmetic products from August 2021. Objectives To describe the time trend of HICC contact allergy in European dermatitis patients in 2009‐2019, and the added value of testing HICC separately in the baseline series. Methods Data of 124 472 dermatitis patients routinely patch tested with HICC 5% pet. in the baseline series in the ESSCA network (2009 to 2018) and at the Department of Dermatology and Allergy at Herlev‐Gentofte Hospital (2009 to 2019) were reviewed. Results Contact allergy to HICC was found in 1.98% of 9 865 patients in Gentofte and 1.62% of 114 607 patients in the ESSCA network. Overall, the prevalence decreased annually with 0.156 percentage points (P = .001) in Gentofte and 0.051 percentage points (P = .0002) in ESSCA. The frequency of missed contact allergy to HICC when testing only with FMII mix was 0.17% (17/9865) and 0.35% (405/114 607) of the whole test population in Gentofte and ESSCA populations, respectively. Conclusions This is the first study to demonstrate a significant decline in HICC allergy in European dermatitis patients, most likely attributed to the upcoming European ban.

ACS Style

Malin Glindvad Ahlström; Wolfgang Uter; Magnus Glindvad Ahlström; Jeanne Duus Johansen. Decrease of contact allergy to hydroxyisohexyl 3‐cyclohexene carboxaldehyde in Europe prior to its ban and diagnostic value. Contact Dermatitis 2021, 84, 419 -422.

AMA Style

Malin Glindvad Ahlström, Wolfgang Uter, Magnus Glindvad Ahlström, Jeanne Duus Johansen. Decrease of contact allergy to hydroxyisohexyl 3‐cyclohexene carboxaldehyde in Europe prior to its ban and diagnostic value. Contact Dermatitis. 2021; 84 (6):419-422.

Chicago/Turabian Style

Malin Glindvad Ahlström; Wolfgang Uter; Magnus Glindvad Ahlström; Jeanne Duus Johansen. 2021. "Decrease of contact allergy to hydroxyisohexyl 3‐cyclohexene carboxaldehyde in Europe prior to its ban and diagnostic value." Contact Dermatitis 84, no. 6: 419-422.

Contact point
Published: 05 January 2021 in Contact Dermatitis
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ACS Style

Wolfgang Uter; Margitta Worm; Richard Brans; Nicola Wagner; Andrea Bauer; Johannes Geier; for the Information Network of Departments of Dermatology (IVDK). Patch test results with caine mix III and its three constituents in consecutive patients of the IVDK. Contact Dermatitis 2021, 84, 481 -483.

AMA Style

Wolfgang Uter, Margitta Worm, Richard Brans, Nicola Wagner, Andrea Bauer, Johannes Geier, for the Information Network of Departments of Dermatology (IVDK). Patch test results with caine mix III and its three constituents in consecutive patients of the IVDK. Contact Dermatitis. 2021; 84 (6):481-483.

Chicago/Turabian Style

Wolfgang Uter; Margitta Worm; Richard Brans; Nicola Wagner; Andrea Bauer; Johannes Geier; for the Information Network of Departments of Dermatology (IVDK). 2021. "Patch test results with caine mix III and its three constituents in consecutive patients of the IVDK." Contact Dermatitis 84, no. 6: 481-483.

Journal article
Published: 28 December 2020 in European Journal of Cancer
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Background The CAO/ARO/AIO trial has shown that oxaliplatin added to preoperative chemoradiotherapy and postoperative chemotherapy significantly improved disease-free survival in locally advanced rectal cancer (LARC). Here, we present a post-hoc analysis of quality of life (QoL) in disease-free patients. Patients and methods Between 2006 and 2010, 1236 patients with LARC were randomly assigned either to preoperative chemoradiotherapy followed by total mesorectal excision and postoperative chemotherapy (N = 623) or combined with oxaliplatin (N = 613). QoL questionnaires (EORTC QLQ-C30, colorectal module CR38) were completed at baseline, after postoperative chemotherapy and during follow-up. Analysis was performed according intent-to-treat. Results Available questionnaires (baseline) were 82% (N = 512) in the control and 84% (N = 513) in the investigational group. Response rates were 49% (533 of 1086) at 1 year and 43% (403 of 928) at 3 years. Global health status (GHS) for disease-free patients was stable in both groups (range 0–100). At baseline: standard arm 62.0 (mean, SD 21.6; N = 491) versus oxaliplatin arm 63.2 (mean, SD 22; N = 503); at 3 years: 69.4 (SD 19.3; N = 187) versus 65.4 (SD 22.2; N = 202). After treatment and at 3 years, no significant differences (≥10 points) between groups were found in QoL subscales. Disease-free patients experiencing neurotoxic side-effects (grade 1–4) showed reduced GHS at 3 years versus patients without neurotoxicity (mean 59.2 versus 69.3; P< 0.001), while grade 3–4 rate was low. Conclusion The addition of oxaliplatin was not associated with worse overall QoL. This information is of interest to patients in many ongoing rectal cancer trials. Trial registration information NCT00349076.

ACS Style

Rebekka Kosmala; Emmanouil Fokas; Michael Flentje; Rolf Sauer; Torsten Liersch; Ullrich Graeven; Rainer Fietkau; Werner Hohenberger; Dirk Arnold; Ralf-Dieter Hofheinz; Michael Ghadimi; Philipp Ströbel; Ludger Staib; Gerhard G. Grabenbauer; Gunnar Folprecht; Simon Kirste; Wolfgang Uter; Christine Gall; Claus Rödel; Bülent Polat. Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial. European Journal of Cancer 2020, 144, 281 -290.

AMA Style

Rebekka Kosmala, Emmanouil Fokas, Michael Flentje, Rolf Sauer, Torsten Liersch, Ullrich Graeven, Rainer Fietkau, Werner Hohenberger, Dirk Arnold, Ralf-Dieter Hofheinz, Michael Ghadimi, Philipp Ströbel, Ludger Staib, Gerhard G. Grabenbauer, Gunnar Folprecht, Simon Kirste, Wolfgang Uter, Christine Gall, Claus Rödel, Bülent Polat. Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial. European Journal of Cancer. 2020; 144 ():281-290.

Chicago/Turabian Style

Rebekka Kosmala; Emmanouil Fokas; Michael Flentje; Rolf Sauer; Torsten Liersch; Ullrich Graeven; Rainer Fietkau; Werner Hohenberger; Dirk Arnold; Ralf-Dieter Hofheinz; Michael Ghadimi; Philipp Ströbel; Ludger Staib; Gerhard G. Grabenbauer; Gunnar Folprecht; Simon Kirste; Wolfgang Uter; Christine Gall; Claus Rödel; Bülent Polat. 2020. "Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial." European Journal of Cancer 144, no. : 281-290.

Review
Published: 28 October 2020 in International Journal of Environmental Research and Public Health
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The rising incidence of cutaneous melanoma over the past few decades has prompted substantial efforts to develop risk prediction models identifying people at high risk of developing melanoma to facilitate targeted screening programs. We review these models, regarding study characteristics, differences in risk factor selection and assessment, evaluation, and validation methods. Our systematic literature search revealed 40 studies comprising 46 different risk prediction models eligible for the review. Altogether, 35 different risk factors were part of the models with nevi being the most common one (n = 35, 78%); little consistency in other risk factors was observed. Results of an internal validation were reported for less than half of the studies (n = 18, 45%), and only 6 performed external validation. In terms of model performance, 29 studies assessed the discriminative ability of their models; other performance measures, e.g., regarding calibration or clinical usefulness, were rarely reported. Due to the substantial heterogeneity in risk factor selection and assessment as well as methodologic aspects of model development, direct comparisons between models are hardly possible. Uniform methodologic standards for the development and validation of risk prediction models for melanoma and reporting standards for the accompanying publications are necessary and need to be obligatory for that reason.

ACS Style

Isabelle Kaiser; Annette B. Pfahlberg; Wolfgang Uter; Markus V. Heppt; Marit B. Veierød; Olaf Gefeller. Risk Prediction Models for Melanoma: A Systematic Review on the Heterogeneity in Model Development and Validation. International Journal of Environmental Research and Public Health 2020, 17, 7919 .

AMA Style

Isabelle Kaiser, Annette B. Pfahlberg, Wolfgang Uter, Markus V. Heppt, Marit B. Veierød, Olaf Gefeller. Risk Prediction Models for Melanoma: A Systematic Review on the Heterogeneity in Model Development and Validation. International Journal of Environmental Research and Public Health. 2020; 17 (21):7919.

Chicago/Turabian Style

Isabelle Kaiser; Annette B. Pfahlberg; Wolfgang Uter; Markus V. Heppt; Marit B. Veierød; Olaf Gefeller. 2020. "Risk Prediction Models for Melanoma: A Systematic Review on the Heterogeneity in Model Development and Validation." International Journal of Environmental Research and Public Health 17, no. 21: 7919.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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Contact dermatitis and contact allergy are common medical conditions. But how common are they? Are certain populations, e.g., certain occupations, more affected than others? Are reactions to specific contact allergens more prevalent than to other allergens or more common in a particular subgroup? This chapter presents some basic epidemiologic principles which are important in population-based or clinic-based studies on contact dermatitis. The chapter deals with methodological issues in the analysis of clinical epidemiological studies, i.e., among patients undergoing patch testing. Common pitfalls are addressed, and factors important for the occurrence of contact dermatitis and/or contact allergy are discussed. Examples of studies on contact allergy as well as contact dermatitis in general are presented.

ACS Style

Wolfgang Uter; Thomas L. Diepgen. Epidemiology of Contact Dermatitis and Contact Allergy. Contact Dermatitis 2020, 195 -216.

AMA Style

Wolfgang Uter, Thomas L. Diepgen. Epidemiology of Contact Dermatitis and Contact Allergy. Contact Dermatitis. 2020; ():195-216.

Chicago/Turabian Style

Wolfgang Uter; Thomas L. Diepgen. 2020. "Epidemiology of Contact Dermatitis and Contact Allergy." Contact Dermatitis , no. : 195-216.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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The desire to change the color of one’s own hair is probably about as old as mankind. Techniques used nowadays involve chemically active substances, mostly in terms of components of so-called oxidative or permanent hair dye cosmetic products. The reaction chemistry is briefly reviewed. Contact allergy to many of these compounds is well demonstrated experimentally and also common according to available clinical data. On a population level, contact allergy to p-phenylenediamine (PPD) affects around 1%, while with morbidity-driven selection, the prevalence of PPD contact allergy in consecutively patch-tested patients is around 4–6%. However, surveys of labelled ingredients indicate that in some European countries (in contrast to, e.g., the USA), PPD has largely been replaced by toluene-2,5-diamine (PTD), which only partially cross-reacts to PPD, and other derivatives. Evidence on the frequency of positive reactions to substances beyond PPD is available from several clinical studies which are presented here. In conclusion, patch test diagnosis has to rely on an adequate hair dye/hair cosmetics series, such as the one suggested recently and presented here. The components of non-oxidative hair dye products need further investigation.

ACS Style

Wolfgang Uter; Jean-Pierre Lepoittevin; Carola Lidén. Contact Allergy to Hair Dyes. Contact Dermatitis 2020, 877 -889.

AMA Style

Wolfgang Uter, Jean-Pierre Lepoittevin, Carola Lidén. Contact Allergy to Hair Dyes. Contact Dermatitis. 2020; ():877-889.

Chicago/Turabian Style

Wolfgang Uter; Jean-Pierre Lepoittevin; Carola Lidén. 2020. "Contact Allergy to Hair Dyes." Contact Dermatitis , no. : 877-889.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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Contact allergy and allergic contact dermatitis are environmental diseases caused by excessive exposure to sensitizing substances in products, such as cosmetics, other consumer items, occupational products, etc. It is possible to prevent the occurrence of these diseases by limiting exposure. This can be done by various methods, such as information, avoidance/protection, restriction of the ingredients to safe levels, or ban. These different methods are reviewed, and examples of the effect of different interventions are given.

ACS Style

Wolfgang Uter; Jeanne Duus Johansen. Prevention of Allergic Contact Dermatitis: Safe Exposure Levels of Sensitizers. Contact Dermatitis 2020, 1187 -1198.

AMA Style

Wolfgang Uter, Jeanne Duus Johansen. Prevention of Allergic Contact Dermatitis: Safe Exposure Levels of Sensitizers. Contact Dermatitis. 2020; ():1187-1198.

Chicago/Turabian Style

Wolfgang Uter; Jeanne Duus Johansen. 2020. "Prevention of Allergic Contact Dermatitis: Safe Exposure Levels of Sensitizers." Contact Dermatitis , no. : 1187-1198.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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Many national and international “contact dermatitis groups” exist. These groups provide an important platform for research, communication, standardization, and specific education. One of the important activities of most groups is to regularly organize congresses and also to liaise with general dermatology societies in terms of organizing symposia and sessions devoted to the topic of contact dermatitis and cutaneous allergy, respectively. Thereby showcasing current research, achievements, and problems in the fields, awareness of this important field of dermatology is increased beyond the actual subspecialty peer group. The following chapter briefly summarizes the history of the most important societies and provides a listing of various (inter)national research groups known at the time of writing (November 2018).

ACS Style

Wolfgang Uter. Contact Dermatitis Research Groups. Contact Dermatitis 2020, 1301 -1304.

AMA Style

Wolfgang Uter. Contact Dermatitis Research Groups. Contact Dermatitis. 2020; ():1301-1304.

Chicago/Turabian Style

Wolfgang Uter. 2020. "Contact Dermatitis Research Groups." Contact Dermatitis , no. : 1301-1304.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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The European baseline series (EBS) of contact allergens is an array of patch test preparations of important contact allergens. The series is of moderate length and is intended to be tested (in Europe) as a baseline, in the sense of a minimum set of allergens required for adequate screening of patients with suspected contact allergy. However, beyond this (and any) baseline series, special test series related to possible causative exposures in the patient as well as his or her own products suspected of causing dermatitis should also be patch tested, for best possible diagnostic sensitivity. The EBS is continually updated, based on consolidated evidence regarding the importance of new allergens – especially those allergens which are often currently clinically relevant. The present chapter presents the EBS (2019 version) and discusses aspects of the single EBS contact allergens relevant for the testing strategy. Basic information on the included allergens is found in the other chapters of this part of the textbook.

ACS Style

Wolfgang Uter; Mark Wilkinson; Margarida Gonçalo. The European Baseline Series. Contact Dermatitis 2020, 679 -695.

AMA Style

Wolfgang Uter, Mark Wilkinson, Margarida Gonçalo. The European Baseline Series. Contact Dermatitis. 2020; ():679-695.

Chicago/Turabian Style

Wolfgang Uter; Mark Wilkinson; Margarida Gonçalo. 2020. "The European Baseline Series." Contact Dermatitis , no. : 679-695.

Book chapter
Published: 13 October 2020 in Contact Dermatitis
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The systematic collection of patch test data, along with demographic and clinical information, within a (national) network has manifold advantages. As a starting point, results can be compared within the network to address possible quality problems. These could be indicated by systematically aberrant local sensitization frequencies not explained by local patient characteristics. Data of sufficient quality can be used and has been used in the past, as illustrated by several examples, for scientific analyses. Analyses may address time trends (surveillance) and subgroups or be multifactorial. Supplemental, external data sources can be linked to patch test data or used for patient management, as illustrated by some examples.

ACS Style

Wolfgang Uter; Axel Schnuch; Ana M. Giménez-Arnau; David Orton; Barry Statham. Databases and Networks: The Benefit for Research and Quality Assurance in Patch Testing. Contact Dermatitis 2020, 1209 -1224.

AMA Style

Wolfgang Uter, Axel Schnuch, Ana M. Giménez-Arnau, David Orton, Barry Statham. Databases and Networks: The Benefit for Research and Quality Assurance in Patch Testing. Contact Dermatitis. 2020; ():1209-1224.

Chicago/Turabian Style

Wolfgang Uter; Axel Schnuch; Ana M. Giménez-Arnau; David Orton; Barry Statham. 2020. "Databases and Networks: The Benefit for Research and Quality Assurance in Patch Testing." Contact Dermatitis , no. : 1209-1224.

Original article
Published: 18 September 2020 in Contact Dermatitis
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Background Clinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series. Objectives To present current results from the European Surveillance System on Contact Allergies (ESSCA), including 13 countries represented by one to 11 departments. Methods Anonymised or pseudonymised patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control. Results In the 4 years 2015–2018, data from 51 914 patients patch tested with the European baseline series of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%) and Myroxyolon pereirae resin (balsam of Peru; 5.8%). Conclusions While the prevalence of MI contact allergy decreased substantially following regulatory intervention, the persistently high levels of allergy to metals, fragrances, other preservatives, and rubber chemicals point to problems needing further research and, potentially, preventive efforts. Results with national additions to the baseline series provide important information on substances possibly to be considered for inclusion in the European baseline series. This article is protected by copyright. All rights reserved.

ACS Style

Wolfgang Uter; Andrea Bauer; Anna Belloni Fortina; Andreas J. Bircher; Richard Brans; Timo Buhl; Susan M. Cooper; Magdalena Czarnecka‐Operacz; Heinrich Dickel; Aleksandra Dugonik; Johannes Geier; Ana M. Giménez‐Arnau; Margarida Gonçalo; Jeanne D. Johansen; Graham A. Johnston; Vera Mahler; Thomas Rustemeyer; Javier Sanchez‐Perez; Marie L.A. Schuttelaar; Dagmar Simon; Radoslaw Spiewak; Skaidra Valiukevičienė; Elke Weisshaar; Ian R. White; Mark Wilkinson; Werner Aberer; Barbara Ballmer‐Weber; Detlef Becker; Ulrike Beiteke; Jochen Brasch; Mahbub M. Chowdhury; Maria Teresa Corradin; Cecilia Dietrich; Rosella Gallo; Jürgen Grabbe; Swen Malte John; Maja Kalac Pandurovic; Nada Kecelj; Tanja Kmecl; Birger Kränke; Francesca Larese Filon; Tomaž Lunder; Pedro Mercader; Alexander Navarini; Andrea Peserico; Maria Pesonen; Inmaculada Ruiz; Anna Sadowska‐Przytocka; Kathrin Scherer‐Hofmeier; Sibylle Schliemann; Mojca Simončič Godnič; Luca Stingeni; Natalie Stone; Marko Vok; Nicola Wagner; Thomas Werfel; ESSCA working group. Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018. Contact Dermatitis 2020, 84, 109 -120.

AMA Style

Wolfgang Uter, Andrea Bauer, Anna Belloni Fortina, Andreas J. Bircher, Richard Brans, Timo Buhl, Susan M. Cooper, Magdalena Czarnecka‐Operacz, Heinrich Dickel, Aleksandra Dugonik, Johannes Geier, Ana M. Giménez‐Arnau, Margarida Gonçalo, Jeanne D. Johansen, Graham A. Johnston, Vera Mahler, Thomas Rustemeyer, Javier Sanchez‐Perez, Marie L.A. Schuttelaar, Dagmar Simon, Radoslaw Spiewak, Skaidra Valiukevičienė, Elke Weisshaar, Ian R. White, Mark Wilkinson, Werner Aberer, Barbara Ballmer‐Weber, Detlef Becker, Ulrike Beiteke, Jochen Brasch, Mahbub M. Chowdhury, Maria Teresa Corradin, Cecilia Dietrich, Rosella Gallo, Jürgen Grabbe, Swen Malte John, Maja Kalac Pandurovic, Nada Kecelj, Tanja Kmecl, Birger Kränke, Francesca Larese Filon, Tomaž Lunder, Pedro Mercader, Alexander Navarini, Andrea Peserico, Maria Pesonen, Inmaculada Ruiz, Anna Sadowska‐Przytocka, Kathrin Scherer‐Hofmeier, Sibylle Schliemann, Mojca Simončič Godnič, Luca Stingeni, Natalie Stone, Marko Vok, Nicola Wagner, Thomas Werfel, ESSCA working group. Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018. Contact Dermatitis. 2020; 84 (2):109-120.

Chicago/Turabian Style

Wolfgang Uter; Andrea Bauer; Anna Belloni Fortina; Andreas J. Bircher; Richard Brans; Timo Buhl; Susan M. Cooper; Magdalena Czarnecka‐Operacz; Heinrich Dickel; Aleksandra Dugonik; Johannes Geier; Ana M. Giménez‐Arnau; Margarida Gonçalo; Jeanne D. Johansen; Graham A. Johnston; Vera Mahler; Thomas Rustemeyer; Javier Sanchez‐Perez; Marie L.A. Schuttelaar; Dagmar Simon; Radoslaw Spiewak; Skaidra Valiukevičienė; Elke Weisshaar; Ian R. White; Mark Wilkinson; Werner Aberer; Barbara Ballmer‐Weber; Detlef Becker; Ulrike Beiteke; Jochen Brasch; Mahbub M. Chowdhury; Maria Teresa Corradin; Cecilia Dietrich; Rosella Gallo; Jürgen Grabbe; Swen Malte John; Maja Kalac Pandurovic; Nada Kecelj; Tanja Kmecl; Birger Kränke; Francesca Larese Filon; Tomaž Lunder; Pedro Mercader; Alexander Navarini; Andrea Peserico; Maria Pesonen; Inmaculada Ruiz; Anna Sadowska‐Przytocka; Kathrin Scherer‐Hofmeier; Sibylle Schliemann; Mojca Simončič Godnič; Luca Stingeni; Natalie Stone; Marko Vok; Nicola Wagner; Thomas Werfel; ESSCA working group. 2020. "Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018." Contact Dermatitis 84, no. 2: 109-120.

Original article
Published: 02 September 2020 in Contact Dermatitis
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Background Studies suggest patch testing with formaldehyde releasers (FRs) give significant additional information to formaldehyde 1% aq. and should be considered for addition to the European baseline series (EBS). It is not known if this is also true for formaldehyde 2% aq. Objectives To determine the frequency of sensitisation to formaldehyde 2% aq. and co‐reactivity with FRs. To establish whether there is justification for including FRs in the EBS. Materials and methods A 4‐year, multi‐centre retrospective analysis of patients with positive patch test reactions to formaldehyde 2% aq. and 5 FRs. Results A maximum of 15067 patients were tested to formaldehyde 2% aq. and at least 1 FR. The percentage of isolated reactions to FR, without co‐reactivity to, formaldehyde 2% aq. for each FR were: 46.8% for quarternium‐15 1% pet.; 67.4% imidazolidinyl urea 2% pet.; 64% diazolidinyl urea 2% pet.; 83.3% DMDM hydantoin 2% pet. and 96.3% 2‐bromo‐2‐nitropropane‐1,3‐diol 0.5% pet. This demonstrates co‐reactivity varies between FRs and formaldehyde, from being virtually non‐existent in 2‐bromo‐2‐nitropropane‐1,3‐diol 0.5% pet. [Cohen's kappa: 0 (95% CI: ‐0.02–0.02)], to only weak concordance for quaternium‐15 [Cohen's kappa: 0.22 (95% CI: 0.16–0.28)], where Cohen's kappa value of 1 would indicate full concordance. Conclusions Formaldehyde 2% aq. is an inadequate screen for contact allergy to the formaldehyde releasers which should be considered for inclusion in any series dependant on the frequency of reactions to and relevance of each individual allergen. This article is protected by copyright. All rights reserved.

ACS Style

Heather Whitehouse; Wolfgang Uter; Johannes Geier; Barbara Ballmer‐Weber; Andrea Bauer; Susan Cooper; Magdalena Czarnecka‐Operacz; Simon Dagmar; Heinrich Dickel; Anna Belloni Fortina; Rosella Gallo; Ana Maria Giménez‐Arnau; Graham A. Johnston; Francesca Laresse Filon; Vera Mahler; Maria Pesonen; Thomas Rustemeyer; Marie L. A. Schuttelaar; Skaidra Valiukevičienė; Elke Weisshaar; Thomas Werfel; S Mark Wilkinson. Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers— results of the ESSCA network, 2015‐2018. Contact Dermatitis 2020, 84, 95 -102.

AMA Style

Heather Whitehouse, Wolfgang Uter, Johannes Geier, Barbara Ballmer‐Weber, Andrea Bauer, Susan Cooper, Magdalena Czarnecka‐Operacz, Simon Dagmar, Heinrich Dickel, Anna Belloni Fortina, Rosella Gallo, Ana Maria Giménez‐Arnau, Graham A. Johnston, Francesca Laresse Filon, Vera Mahler, Maria Pesonen, Thomas Rustemeyer, Marie L. A. Schuttelaar, Skaidra Valiukevičienė, Elke Weisshaar, Thomas Werfel, S Mark Wilkinson. Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers— results of the ESSCA network, 2015‐2018. Contact Dermatitis. 2020; 84 (2):95-102.

Chicago/Turabian Style

Heather Whitehouse; Wolfgang Uter; Johannes Geier; Barbara Ballmer‐Weber; Andrea Bauer; Susan Cooper; Magdalena Czarnecka‐Operacz; Simon Dagmar; Heinrich Dickel; Anna Belloni Fortina; Rosella Gallo; Ana Maria Giménez‐Arnau; Graham A. Johnston; Francesca Laresse Filon; Vera Mahler; Maria Pesonen; Thomas Rustemeyer; Marie L. A. Schuttelaar; Skaidra Valiukevičienė; Elke Weisshaar; Thomas Werfel; S Mark Wilkinson. 2020. "Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers— results of the ESSCA network, 2015‐2018." Contact Dermatitis 84, no. 2: 95-102.

Original article
Published: 26 August 2020 in Contact Dermatitis
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Background There is considerable variability across European patch test centres as to which allergens are included in local and national cosmetics series. Objectives To propose a standardised, evidence‐based cosmetic series for Europe based on up‐to‐date analysis of relevant contact allergens. Methods We collated data from the European Surveillance System on Contact Allergies (ESSCA) from 2009–2018 to determine which cosmetic allergens produce a high yield of contact allergy. Contact allergens with a prevalence of >0.3% that were considered relevant were included. Rare contact allergens were excluded if deemed no longer relevant or added to a supplemental cosmetic series for further analysis. Results Sensitisation prevalence rates of 39 cosmetic contact allergens are tabulated. Thirty of these allergens yield >0.3% positive reactions and are therefore included in our proposed European Cosmetic Series. Six are considered no longer relevant and therefore excluded. Three are included in a supplementary European cosmetic series. An additional 9 allergens are included in either the core or supplemental European cosmetic series following literature review. Conclusion We have derived a potential European cosmetic series based upon the above methods. This will require ongoing investigation based upon the changing exposure profiles of cosmetic allergens as well as new and evolving substances. This article is protected by copyright. All rights reserved.

ACS Style

Emma Horton; Wolfgang Uter; Johannes Geier; Barbara Ballmer‐Weber; Andrea Bauer; Andreas Bircher; Heinrich Dickel; Ana Giménez‐Arnau; Margarida Gonçalo; Swen Malte John; Vera Mahler; Marie L. A. Schuttelaar; Dagmar Simon; Javier Sanchez‐Perez; Thomas Rustemeyer; Elke Weisshaar; S Mark Wilkinson. Developing a cosmetic series: Results from the ESSCA network, 2009‐2018. Contact Dermatitis 2020, 84, 82 -94.

AMA Style

Emma Horton, Wolfgang Uter, Johannes Geier, Barbara Ballmer‐Weber, Andrea Bauer, Andreas Bircher, Heinrich Dickel, Ana Giménez‐Arnau, Margarida Gonçalo, Swen Malte John, Vera Mahler, Marie L. A. Schuttelaar, Dagmar Simon, Javier Sanchez‐Perez, Thomas Rustemeyer, Elke Weisshaar, S Mark Wilkinson. Developing a cosmetic series: Results from the ESSCA network, 2009‐2018. Contact Dermatitis. 2020; 84 (2):82-94.

Chicago/Turabian Style

Emma Horton; Wolfgang Uter; Johannes Geier; Barbara Ballmer‐Weber; Andrea Bauer; Andreas Bircher; Heinrich Dickel; Ana Giménez‐Arnau; Margarida Gonçalo; Swen Malte John; Vera Mahler; Marie L. A. Schuttelaar; Dagmar Simon; Javier Sanchez‐Perez; Thomas Rustemeyer; Elke Weisshaar; S Mark Wilkinson. 2020. "Developing a cosmetic series: Results from the ESSCA network, 2009‐2018." Contact Dermatitis 84, no. 2: 82-94.

Reference work
Published: 10 June 2020 in Contact Dermatitis
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The desire to change the color of one’s own hair is probably about as old as mankind. Techniques used nowadays involve chemically active substances, mostly in terms of components of so-called oxidative or permanent hair dye cosmetic products. The reaction chemistry is briefly reviewed. Contact allergy to many of these compounds is well demonstrated experimentally and also common according to available clinical data. On a population level, contact allergy to p-phenylenediamine (PPD) affects around 1%, while with morbidity-driven selection, the prevalence of PPD contact allergy in consecutively patch-tested patients is around 4–6%. However, surveys of labelled ingredients indicate that in some European countries (in contrast to, e.g., the USA), PPD has largely been replaced by toluene-2,5-diamine (PTD), which only partially cross-reacts to PPD, and other derivatives. Evidence on the frequency of positive reactions to substances beyond PPD is available from several clinical studies which are presented here. In conclusion, patch test diagnosis has to rely on an adequate hair dye/hair cosmetics series, such as the one suggested recently and presented here. The components of non-oxidative hair dye products need further investigation.

ACS Style

Wolfgang Uter; Jean-Pierre Lepoittevin; Carola Lidén. Contact Allergy to Hair Dyes. Contact Dermatitis 2020, 1 -13.

AMA Style

Wolfgang Uter, Jean-Pierre Lepoittevin, Carola Lidén. Contact Allergy to Hair Dyes. Contact Dermatitis. 2020; ():1-13.

Chicago/Turabian Style

Wolfgang Uter; Jean-Pierre Lepoittevin; Carola Lidén. 2020. "Contact Allergy to Hair Dyes." Contact Dermatitis , no. : 1-13.

Reference work
Published: 04 June 2020 in Contact Dermatitis
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Contact dermatitis and contact allergy are common medical conditions. But how common are they? Are certain populations, e.g., certain occupations, more affected than others? Are reactions to specific contact allergens more prevalent than to other allergens or more common in a particular subgroup? This chapter presents some basic epidemiologic principles which are important in population-based or clinic-based studies on contact dermatitis. The chapter deals with methodological issues in the analysis of clinical epidemiological studies, i.e., among patients undergoing patch testing. Common pitfalls are addressed, and factors important for the occurrence of contact dermatitis and/or contact allergy are discussed. Examples of studies on contact allergy as well as contact dermatitis in general are presented.

ACS Style

Wolfgang Uter; Thomas L. Diepgen. Epidemiology of Contact Dermatitis and Contact Allergy. Contact Dermatitis 2020, 1 -22.

AMA Style

Wolfgang Uter, Thomas L. Diepgen. Epidemiology of Contact Dermatitis and Contact Allergy. Contact Dermatitis. 2020; ():1-22.

Chicago/Turabian Style

Wolfgang Uter; Thomas L. Diepgen. 2020. "Epidemiology of Contact Dermatitis and Contact Allergy." Contact Dermatitis , no. : 1-22.

Review
Published: 01 April 2020 in International Journal of Environmental Research and Public Health
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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

ACS Style

Wolfgang Uter; Thomas Werfel; Jean-Pierre Lepoittevin; Ian R. White. Contact Allergy—Emerging Allergens and Public Health Impact. International Journal of Environmental Research and Public Health 2020, 17, 2404 .

AMA Style

Wolfgang Uter, Thomas Werfel, Jean-Pierre Lepoittevin, Ian R. White. Contact Allergy—Emerging Allergens and Public Health Impact. International Journal of Environmental Research and Public Health. 2020; 17 (7):2404.

Chicago/Turabian Style

Wolfgang Uter; Thomas Werfel; Jean-Pierre Lepoittevin; Ian R. White. 2020. "Contact Allergy—Emerging Allergens and Public Health Impact." International Journal of Environmental Research and Public Health 17, no. 7: 2404.