This study presents a comprehensive investigation into multi-directional fatigue damage characteristics of fixed offshore wind turbine tower roots through comparative analysis using FAST (3.5.0) and Bladed (4.3) software platforms. The research methodology encompasses three principal phases: First, a stochastic wind field model was developed through statistical analysis of historical wind speed measurements, achieving superior correlation (R² = 0.983) in goodness-of-fit tests. Subsequently, the rain flow counting technique was employed to characterize equivalent cyclic load spectra. Building upon these foundations, an integrated predictive fatigue life evaluation framework was formulated by synergistically combining S–N curve principles with Palmgren–Miner’s linear cumulative damage theory. The methodology was further validated through cross-platform verification with Bladed software, revealing only a 7.4% deviation in predicted fatigue lives between the two computational models, confirming the technical feasibility of the proposed simplified model.