India bears a huge burden of hemoglobinopathies, and the most prevalent is thalassemia. The different types of thalassemia include minor, major and intermedia, based on the α/β-globin chain inequality. This review aimed to understand the current prevalence of thalassemia in different regions of India and communities affected by it, along with the management of β-thalassemia major (β-TM) and β-thalassemia (β-thal) minor patients. A comprehensive electronic search for relevant articles was conducted using two databases, i.e. PubMed and Science Direct. Articles published in English from India between January 2009 and September 2021 were included. Studies from other countries, genetic and molecular characterization studies, and articles published in other languages were excluded. The prevalence of β-thal trait in Central India ranged between 1.4 and 3.4%, while 0.94% β-TM was reported among the patients with anemia. In South India, the prevalence of β-thal trait was between 8.50 and 37.90% and β-TM was reported to be between 2.30 and 7.47%. Northern and Western Indian states had a higher thalassemic burden. In Eastern India, tribal populations had a higher prevalence of β-thal trait (0.00–30.50%), β-TM (0.36–13.20%) and other hemoglobinopathies [Hb E (HBB: c.79G>A)/β-thal] (0.04–15.45%) than nontribal populations. Additionally, scheduled castes, scheduled tribes and other backward classes of low socioeconomic status and low literacy rates were affected by β-thal. Almost all Indian states reported β-thal; however, it is mostly concentrated in eastern and western parts of the country. Well-integrated strategies and effective implementation are needed at State and National levels to minimize the burden of β-thal.

Background/Objectives: Malnutrition in children is a challenge in South Asian countries, and understanding its relation with variety of social and economic conditions is imperative. The present systematic review examined the association between maternal employment and the nutritional status of children up to twelve years old from South Asia. Methods: An electronic search for research articles published in the English language between January 2011 and December 2024 was conducted in PubMed, Science Direct, and Web of Science databases. Results: A total of 10,247 articles from five South Asian countries were screened, resulting in the inclusion of 19 studies in the review based on well-defined inclusion and exclusion criteria. The findings showed that the association between maternal employment and children’s nutritional status was context-dependent, with adverse effects in children (stunting, wasting, and growth failure) when mothers worked in unskilled sectors—in low-paying jobs. Children of urban mothers had poor nutritional status, often exacerbated by the lack of or limited childcare support and financial assistance during their work absences. Additionally, many South Asian countries implemented maternal and paternal leave policies and benefits; however, the implementation challenges reduced maternal access to these benefits and predominantly favored mothers working in formal sectors. Conclusions: This systematic review underscores the necessity to strengthen the employment benefit programs for working women in South Asian countries, especially for mothers working in informal sectors. The provision of childcare assistance and supplementary financial benefits to women employed in informal sectors is essential to improve the child nutritional outcomes.

The school food environment plays a significant role in children’s nutritional well-being. The widespread accessibility and availability of unhealthy