The synthesis, reactivity and applications of glycerol carbonate (glycerine carbonate or 4-hydroxymethyl-2-oxo-1,3-dioxolane) are discussed and reviewed. Supported by the increasing sustainable awareness, glycerol carbonate has gained much interest over the last 20 years because of its versatile reactivity and as a way to valorize waste glycerol. Numerous synthesis pathways for this molecule were identified, some of them very promising and on the verge of being applied at an industrial scale. The wide reactivity of this molecule due to the presence of both a hydroxyl group and a 2-oxo-1,3-dioxolane group has been studied and has initiated some emerging applications in various domains from solvents to polymers.